一种甲钴胺片剂及其制备方法

By using a silica mesoporous carrier and a light-shielding coating layer for methylcobalamin tablets, the problems of photostability and content uniformity of methylcobalamin tablets are solved, resulting in a more stable and simpler preparation process suitable for industrial production.

CN121466022BActive Publication Date: 2026-07-17SHANDONG QIDU PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG QIDU PHARMA
Filing Date
2026-01-06
Publication Date
2026-07-17

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Abstract

本发明属于药物制剂技术领域，具体涉及一种甲钴胺片剂及其制备方法。所述的甲钴胺片剂，包括以下重量份数的成分：甲钴胺1份、二氧化硅介孔载体10~20份、填充剂142~149份、崩解剂14~18份、润滑剂1~2份、薄膜包衣预混剂6~8份。本发明将甲钴胺分子分散于二氧化硅介孔载体的内部多孔结构中，孔道隔离与遮光剂包衣层协同防护减少药物暴露，提高甲钴胺的光稳定性与含量均匀性，进而获得更稳定、均一的甲钴胺片；本发明还提供其制备方法，工艺流程简洁，生产周期短，生产连续性好，机械化程度高，适合工业化生产。
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