一种基于模板衍生硼亲和印迹策略构筑的纸基磺胺嘧啶传感器及其制备方法和应用

By constructing FP@B-MOF@MIP materials on paper substrates using a template-derived boron affinity imprinting strategy, the problems of high cost and poor biological receptor stability in existing technologies for sulfadiazine detection are solved, achieving low-cost, rapid, and sensitive sulfadiazine detection with an imprinting factor as high as 5.6.

CN121473169BActive Publication Date: 2026-07-17ZHEJIANG FORESTRY UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG FORESTRY UNIVERSITY
Filing Date
2025-11-13
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In existing technologies, the detection methods for sulfadiazine suffer from high costs, require specialized operation, and have poor stability of biological receptors. Furthermore, the poor orderliness of the imprints on MOF/MIPs materials leads to suboptimal analytical performance.

Method used

A template-derived boron affinity imprinting strategy was adopted to prepare the derivatized template SDZ-CD via Schiff base reaction, and FP@B-MOF@MIP material was constructed on a paper substrate. The paper-based imprinted material FP@B-MOF@MIP with ordered cavities was prepared by free radical polymerization and detected by colorimetry.

Benefits of technology

It achieves convenient, sensitive, and rapid visual detection, with low cost and simple operation. It can efficiently identify and enrich trace amounts of sulfadiazine in complex food matrices, with an imprint factor of 5.6, significantly improving detection performance.

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Abstract

本发明提供了一种基于模板衍生硼亲和印迹策略构筑的纸基磺胺嘧啶传感器及其制备方法和应用,属于磺胺嘧啶传感器技术领域。本发明将磺胺嘧啶和2,3‑二羟基苯甲醛通过席夫碱反应制备出顺式二羟基衍生的新型磺胺嘧啶虚拟模板。以纤维素滤纸作为基底,Zn2+作为配位中心,通过水热法在纸基上构筑硼酸功能化MOF(FP@B‑MOF),将合成的虚拟模板和MOF表面硼酸结合实现模板的有序固定,并通过自由基聚合法制备出纸基衍生硼亲和印迹材料(FP@B‑MOF@MIP)。FP@B‑MOF@MIP可高效选择性识别与富集磺胺嘧啶,进一步结合对二甲氨基苯甲醛与磺胺嘧啶的显色反应实现痕量磺胺嘧啶的可视化检测。
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