Graphene oxide-silk fibroin-gallic acid composite hydrogel as well as preparation method and application thereof

Abstract

The invention relates to the technical field of hydrogel preparation, in particular to graphene oxide-silk fibroin-gallic acid composite hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing a graphene oxide dispersion liquid and gallic acid, and reacting to obtain a graphene oxide-gallic acid dispersion liquid; and mixing the silk fibroin solution with the graphene oxide-gallic acid dispersion liquid, and carrying out gelation to obtain the graphene oxide-silk fibroin-gallic acid composite hydrogel. Silk fibroin is used as a three-dimensional network matrix, graphene oxide is used as a conductive reinforcing material, and gallic acid is used as an antioxidant and anti-inflammatory active component. Through the synergistic effect of physical and chemical crosslinking, a multifunctional composite system with good mechanical property, good conductivity, biological activity, long-acting anti-oxidation / anti-inflammatory activity, controllable degradability and injectability is formed, and the composite material is used for filling nerve conduits or is directly injected to injured parts to provide a suitable microenvironment for nerve regeneration.

Images