A high-molecular denture adhesive paste and a preparation method thereof

Abstract

The application relates to the technical field of denture adhesive agents, and specifically discloses a high-molecular denture fixing paste, which comprises the following components in parts by weight: amphiphilic block copolymer 30-55 parts, tackifying resin 10-25 parts, biocompatible plasticizing agent 20-35 parts, thixotropic enhancer 3-8 parts and functional auxiliary agent 0.5-5 parts; the amphiphilic block copolymer is selected from polyethylene glycol-poly-caprolactone block copolymer and / or catechol-terminated polyethylene glycol-poly-lactic acid block copolymer; in the polyethylene glycol-poly-caprolactone block copolymer, the number-average molecular weight of the polyethylene glycol block is 2000-5000 Da, and the number-average molecular weight of the poly-caprolactone block is 3000-6000 Da. The high-molecular denture fixing paste provided by the application can firmly bridge the denture and the tissue, can effectively resist the dissolution and flushing of saliva, and can maintain the structural integrity and adhesive force for 12-18 hours.

Description

Technical Field

[0001] This application relates to the field of denture adhesive technology, specifically to a polymer denture adhesive and its preparation method. Background Technology

[0002] Denture wearers often face problems with poor denture retention due to alveolar ridge resorption, fabrication errors, and other reasons. Denture retention materials, as functional auxiliary materials that enhance denture retention, can improve denture stability by adhering to the denture base and oral mucosa, thereby preventing problems such as denture loosening or falling out during chewing and speaking.

[0003] Currently, the main adhesive film-forming components of existing denture fixation materials are mostly conventional water-soluble polymers such as sodium carboxymethyl cellulose (CMC) and methyl vinyl ether-maleic anhydride copolymer salt (PVM-MA). However, these materials have significant technical drawbacks: First, the adhesion mechanism relies solely on physical adsorption and hydrogen bonding. In the moist environment of the oral cavity (saliva rinsing and chewing friction), the adhesion weakens rapidly, and the effective retention time is usually only 4-8 hours, which cannot meet the needs of users for long-term wear. Second, the polymer chain segments have poor hydrophilic-hydrophobic balance. Either the hydrophilicity is too strong, causing the material to easily swell and be lost, or the hydrophobicity is too strong, resulting in insufficient flexibility and easy cracking after film formation, which greatly shortens the retention time. Third, the polymer materials in the existing formulations lack specific interaction sites, resulting in limited bonding strength with the denture base (acrylic resin, porcelain) and oral mucosa, making it difficult to achieve long-term stable retention. In addition, there are reports of non-water-soluble denture adhesives that use polyvinyl acetate as the main adhesive component. These materials are water-insoluble and their adhesion will not gradually decrease due to moisture, and can last for up to 24 hours. However, the above materials make it more difficult to remove dentures in advance, and it is also difficult to remove the residue on the dentures.

[0004] Therefore, there is an urgent need to develop a new type of polymer system denture fixing material to achieve long-term, reliable denture stability and easy cleaning. Summary of the Invention

[0005] In order to overcome the shortcomings of existing denture securing materials, this application provides a polymer denture securing paste with strong adhesion, good durability (up to 12-18h), water erosion resistance, and easy removal and cleaning, as well as its preparation method.

[0006] In the first aspect, this application provides a polymer denture fixation paste, which adopts the following technical solution: A polymeric denture adhesive comprises the following components in parts by weight: 30-55 parts of amphiphilic block copolymer, 10-25 parts of tackifying resin, 20-35 parts of biocompatible shaping agent, 3-8 parts of thixotropic enhancer, and 0.5-5 parts of functional additives. The amphiphilic block copolymer is selected from polyethylene glycol-polycaprolactone block copolymer and / or catechol-terminated polyethylene glycol-polylactic acid block copolymer; In the polyethylene glycol-polycaprolactone block copolymer, the number average molecular weight of the polyethylene glycol block is 2000-5000 Da, and the number average molecular weight of the polycaprolactone block is 3000-6000 Da.

[0007] This application provides a polymeric denture adhesive, which uses polyethylene glycol-polycaprolactone block copolymer (PEG-PCL) and / or catechol-terminated polyethylene glycol-polylactic acid block copolymer as the main components. The hydrophobic blocks (PCL and PLA) can firmly anchor to the denture base, while the hydrophilic blocks (PEG) can bind to the mucosal hydration layer. At the same time, the catechol groups provide strong biomimetic wet adhesion, thereby constructing a firmly adhering bridging network, which allows the denture adhesive to firmly bond to the hydrophobic surface of the denture and the moist mucosa of the oral cavity. In addition, the polymeric denture adhesive of this application mainly achieves physical cross-linking by forming a viscoelastic network, without relying on the swelling mechanism of traditional hydrogels. Therefore, it can effectively resist the continuous dissolution of saliva and the rinsing of drinking water. Combined with the excellent initial tack provided by the tackifying resin, the denture can maintain stable and significant adhesion strength during the 12-18 hour service period, even under chewing and speaking activities. Furthermore, the polymer denture adhesive of this application also contains biocompatible shaping agents and thixotropic enhancers, which ensure that the adhesive has suitable extrudability, flexibility, and thixotropy. It is easy to apply and mold during use and does not easily collapse. Moreover, even after long-term use, the adhesive layer can still gently decrease the interfacial adhesion through water penetration, enabling easy removal and cleaning of dentures. In summary, through material selection and optimization of the formulation of each component, this application provides a novel polymer denture adhesive with strong adhesion, excellent durability, and safety and comfort. It successfully solves the problems of existing adhesives that cannot simultaneously achieve ultra-long-lasting strong retention, excellent water resistance, and ease of use, and has a promising future.

[0008] Optionally, the polymer denture adhesive comprises the following components in parts by weight: 35-50 parts of amphiphilic block copolymer, 15-20 parts of tackifying resin, 25-35 parts of biocompatible shaping agent, 3-8 parts of thixotropic enhancer, and 0.5-5 parts of functional additives.

[0009] Optionally, the amphiphilic block copolymer is a mixture of polyethylene glycol-polycaprolactone block copolymer and catechol-terminated polyethylene glycol-polylactic acid block copolymer.

[0010] Optionally, the weight ratio of the polyethylene glycol-polycaprolactone block copolymer and the catechol-terminated polyethylene glycol-polylactic acid block copolymer is 1:(0.2-0.5).

[0011] In some embodiments, the weight ratio of the polyethylene glycol-polycaprolactone block copolymer and the catechol-terminated polyethylene glycol-polylactic acid block copolymer can be 1:(0.2-0.3), 1:(0.2-0.4), 1:(0.2-0.5), 1:(0.3-0.4), 1:(0.3-0.5), or 1:(0.4-0.5).

[0012] In one specific implementation, the weight ratio of the polyethylene glycol-polycaprolactone block copolymer and the catechol-terminated polyethylene glycol-polylactic acid block copolymer can also be 1:0.2, 1:0.3, 1:0.4, 1:0.5 or 1:1.

[0013] Optionally, the tackifying resin is hydrogenated rosin glycerol ester and / or terpene resin.

[0014] Optionally, the biocompatible plasticizer is selected from one or more of light mineral oil, polydimethylsiloxane, caprylic triglyceride, and caprylic triglyceride.

[0015] Optionally, the thixotropic enhancer is nanocrystalline cellulose.

[0016] Optionally, the functional additive is selected from one or more of preservatives, rheology modifiers, humectants, and colorants.

[0017] Secondly, this application provides a method for preparing a polymer denture adhesive, characterized by comprising the following steps: Amphiphilic block copolymer and tackifying resin are dissolved in volatile solvent to obtain a glue solution; then a biocompatible plasticizer and a thixotropic enhancer are added to the glue solution in sequence and dispersed at high speed to obtain a crude paste; the crude paste is heated under vacuum, and finally functional additives are added and stirred evenly to obtain a polymer denture fixation paste.

[0018] Optionally, the vacuum heating temperature is 40-50℃, the vacuum degree is -0.1~-0.5MPa, and the time is 2-4h.

[0019] Optionally, the volatile solvent is ethyl acetate or acetone.

[0020] Thirdly, this application provides the use of a polymer denture fixative paste in the preparation of oral care products for removable dentures.

[0021] In summary, this application has the following beneficial effects: 1. This application uses polyethylene glycol-polycaprolactone block copolymer and / or catechol-terminated polyethylene glycol-polylactic acid block copolymer as the main components. The resulting polymer denture adhesive can form a viscoelastic three-dimensional network layer between the denture and the tissue, so that the polymer denture adhesive can achieve a stable bond between the hydrophobic surface of the denture and the moist oral mucosa interface.

[0022] 2. The polymer denture adhesive provided in this application achieves excellent adhesion, durability, and water resistance through intermolecular physical forces. Therefore, it can effectively resist the dissolution and erosion of saliva, and can maintain structural integrity and adhesion for up to 12-18 hours under dynamic actions such as chewing and speaking.

[0023] 3. The polymer denture adhesive provided in this application has good biocompatibility and easy removal. After long-term use, the adhesion of the adhesive layer edge can decrease due to slight enzymatic hydrolysis and mechanical fatigue. Users can rinse their mouths or soak their mouths to allow a small amount of water to penetrate to the interface. The PEG blocks hydrate and swell slightly, thereby slowly reducing the interfacial adhesion and achieving complete peeling or brushing removal. Detailed Implementation

[0024] This application provides a polymeric denture fixation paste, comprising the following components in parts by weight: 30-55 parts of amphiphilic block copolymer, 10-25 parts of tackifying resin, 20-35 parts of biocompatible shaping agent, 3-8 parts of thixotropic enhancer, 0.1-1 part of preservative, 0.1-1 part of rheology modifier, 0.5-1 part of humectant, and 0.005-0.01 part of colorant; further, the polymeric denture fixation paste comprises the following components in parts by weight: 35-50 parts of amphiphilic block copolymer, 15-20 parts of tackifying resin, 25-35 parts of biocompatible shaping agent, 3-8 parts of thixotropic enhancer, 0.1-1 part of preservative, 0.1-1 part of rheology modifier, and 0.005-0.01 part of colorant.

[0025] The amphiphilic block copolymer is selected from polyethylene glycol-polycaprolactone block copolymers and / or catechol-terminated polyethylene glycol-polylactic acid block copolymers; in the polyethylene glycol-polycaprolactone block copolymer, the number average molecular weight of the polyethylene glycol blocks is 2000-5000 Da, and the number average molecular weight of the polycaprolactone blocks is 3000-6000 Da. Further, the amphiphilic block copolymer is a mixture of polyethylene glycol-polycaprolactone block copolymers and catechol-terminated polyethylene glycol-polylactic acid block copolymers.

[0026] The preparation method of the polymer denture adhesive provided in this application includes the following steps: dissolving an amphiphilic block copolymer and a tackifying resin in ethyl acetate or acetone to obtain a glue solution; then sequentially adding a biocompatible plasticizer and a thixotropic enhancer to the glue solution, stirring at a speed of 800-1200 r / min for 20-30 min to obtain a crude paste; then vacuum heating the crude paste solution at a temperature of 40-50℃ and a vacuum degree of -0.1~-0.5 MPa for 2-4 h; finally adding functional additives and stirring evenly to obtain the polymer denture adhesive.

[0027] In the embodiments of this application, the polyethylene glycol-polycaprolactone block copolymer and the catechol-terminated polyethylene glycol-polylactic acid block copolymer are self-made by our company; the tackifying resin is hydrogenated rosin glycerol ester, CAS number 65997-13-9, purchased from Maclean's; the biocompatible plasticizer is polydimethylsiloxane, CAS number 9006-65-9, purchased from Maclean's; the thixotropic enhancer is nanocrystalline cellulose, CAS number 9004-34-6, purchased from Merck; the preservative is methylparaben; the rheology modifier is fumed silica; the humectant is glycerin; and the colorant is azorubicin. All raw materials, reagents, solvents, etc. used in this application are commercially available.

[0028] The following describes this application in further detail with reference to preparation examples, embodiments, and performance testing.

[0029] Preparation Example 1

[0030] Preparation Example 1 provides a polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000).

[0031] The preparation method of the above-mentioned polyethylene glycol-polycaprolactone block copolymer is as follows: 100 g of monomethoxy polyethylene glycol mPEG5000 and 200 mL of dry toluene are added to a three-necked flask equipped with a magnetic stirrer and a condenser. The mixture is heated to approximately 100°C in an oil bath, and nitrogen gas is introduced and the gas is purged several times. After the mPEG is completely dissolved, the system is cooled to 80-90°C. 60 g of ε-caprolactone monomer ε-CL is added to the flask using a dry syringe, followed by 25 mL of a toluene solution of catalyst Sn(Oct)2 (containing 300 mg of catalyst). The reaction system is heated to 120°C and magnetically stirred for 24 h under nitrogen protection. After the reaction is completed, the system is cooled to room temperature. Add about 1 mL of glacial acetic acid and stir for 0.5 h to terminate the reaction and neutralize the catalyst; finally, slowly drop the reaction solution into 2 L of vigorously stirred pre-cooled anhydrous diethyl ether. The product will precipitate as a white fibrous or waxy solid; after filtration, washing three times with cold diethyl ether, and vacuum drying, a white solid is obtained, which is polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000).

[0032] Preparation Example 2

[0033] Preparation Example 2 provides a polyethylene glycol-polycaprolactone block copolymer (PEG2000-PCL5000).

[0034] The preparation method of the above-mentioned polyethylene glycol-polycaprolactone block copolymer is as follows: 150g of monomethoxy polyethylene glycol mPEG2000 and 200mL of dry toluene are added to a three-necked flask equipped with a magnetic stirrer and a condenser. The mixture is heated to approximately 100°C in an oil bath, and nitrogen gas is introduced and the gas is purged several times. After the mPEG is completely dissolved, the system is cooled to 80°C. 375g of ε-caprolactone monomer ε-CL is added to the flask using a dry syringe, followed by 50mL of a toluene solution of catalyst Sn(Oct)2 (containing 750mg of catalyst). The reaction system is heated to 120°C and magnetically stirred for 24h under nitrogen protection. After the reaction is completed, the system is cooled to room temperature. Add about 10 mL of glacial acetic acid and stir for 0.5 h to terminate the reaction and neutralize the catalyst. Finally, slowly drop the reaction solution into 2 L of vigorously stirred pre-cooled anhydrous diethyl ether. The product will precipitate as a white fibrous or waxy solid. After filtration, washing three times with cold diethyl ether, and vacuum drying, a white solid is obtained, which is polyethylene glycol-polycaprolactone block copolymer (PEG2000-PCL5000).

[0035] Preparation Example 3

[0036] Preparation Example 3 provides a catechol-terminated polyethylene glycol-polylactic acid block copolymer.

[0037] The preparation method of the above-mentioned catechol-terminated polyethylene glycol-polylactic acid block copolymer includes the following steps: (1) First, add carboxyl-terminated polyethylene glycol COOH-PEG-COOH (20g, 10mmol) and L-lactide (36g, 250mmol) to a 500mL dry three-necked flask; purge with nitrogen and maintain an inert atmosphere, quickly add stannous octoate (25mg), heat to 135℃, and keep the reaction at this temperature for 24h to carry out ring-opening polymerization; after the reaction is completed, cool to room temperature, add 100mL of dichloromethane and stir to dissolve the product, then slowly drop the solution into 50mL of ice-cold ether, and the product will precipitate; filter to collect the precipitate, wash it 3 times with ice-cold ether, and dry it under vacuum at 40℃ for 8h to obtain COOH-PEG-PLA.

[0038] (2) Take 10g of COOH-PEG-PLA obtained in step (1) and add it to a flask, and pour in 100mL of anhydrous DMSO. Stir at room temperature for 30min to completely dissolve it. Then add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.3g, 12mmol) and N-hydroxysuccinimide (1.38g, 12mmol), and stir to activate the carboxyl group for 30min. Then add dopamine hydrochloride (1.53g, 8mmol), and add N,N-diisopropylethylamine to adjust the pH of the system to 7.5. React at room temperature in the dark for 24h. After the reaction is completed, slowly add the reaction solution to 30mL of ice-cold ether to precipitate, filter and collect the solid. Dissolve the solid in 100mL of deionized water, put it into a dialysis bag with a molecular weight cutoff of 3500Da, and dialyze with deionized water for 24h to remove unreacted dopamine, EDCI and other small molecule impurities. Finally, the dialysate was freeze-dried for 24 hours to obtain a pale yellow solid, which is the catechol-terminated polyethylene glycol-polylactic acid block copolymer. The successful end-capping was confirmed by NMR characterization.

[0039] Examples 1-5

[0040] Examples 1-5 each provide a polymer denture fixation paste.

[0041] The difference in the above embodiments is that the amount of each component added is shown in Table 1 below.

[0042] The preparation method of the polymer denture fixation paste provided in Examples 1-5 includes the following steps: dissolving the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) and tackifying resin (hydrogenated rosin glycerol ester) obtained in Example 1 in ethyl acetate solvent to obtain a glue solution; then adding a biocompatible plasticizer (polydimethylsiloxane) and 5g of thixotropic enhancer (nanocrystalline cellulose) to the glue solution sequentially, and stirring at 1000r / min for 30min to obtain a crude paste; then vacuum heating the crude paste at 45℃ and -0.2MPa for 4h, and finally adding 0.5g of preservative, 0.5g of rheology modifier, 1g of humectant and 0.01g of colorant, and stirring evenly to obtain the polymer denture fixation paste.

[0043] Table 1. Amounts of some ingredients added to the polymer denture adhesive provided in Examples 1-5 Example 6

[0044] Example 6 provides a polymer denture fixation paste.

[0045] The difference between the above embodiments and Embodiment 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) was replaced with the polyethylene glycol-polycaprolactone block copolymer (PEG2000-PCL5000) obtained in Preparation Example 2. Example 7

[0046] Example 7 provides a polymer denture fixation paste.

[0047] The difference between the above embodiments and Embodiment 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) was replaced with the catechol-terminated polyethylene glycol-polylactic acid block copolymer obtained in Preparation Example 3. Example 8

[0048] Example 8 provides a polymer denture fixation paste.

[0049] The difference between the above embodiment and Example 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) is replaced with a mixture of PEG5000-PCL3000 and catechol-terminated polyethylene glycol-polylactic acid block copolymer in a weight ratio of 1:1. Example 9

[0050] Example 9 provides a polymer denture fixation paste.

[0051] The difference between the above embodiment and Example 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) is replaced with a mixture of PEG5000-PCL3000 and catechol-terminated polyethylene glycol-polylactic acid block copolymer in a weight ratio of 1:0.5. Example 10

[0052] Example 10 provides a polymer denture fixation paste.

[0053] The difference between the above embodiment and Example 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) is replaced with a mixture of PEG5000-PCL3000 and catechol-terminated polyethylene glycol-polylactic acid block copolymer in a weight ratio of 1:0.4. Example 11

[0054] Example 11 provides a polymer denture fixation paste.

[0055] The difference between the above embodiment and Example 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) is replaced with a mixture of PEG5000-PCL3000 and catechol-terminated polyethylene glycol-polylactic acid block copolymer in a weight ratio of 1:0.3. Example 12

[0056] Example 12 provides a polymer denture fixation paste.

[0057] The difference between the above embodiment and embodiment 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) is replaced with a mixture of PEG5000-PCL3000 and catechol-terminated polyethylene glycol-polylactic acid block copolymer in a weight ratio of 1:0.2. Comparative Example 1

[0058] Comparative Example 1 provides a polymer denture fixation paste.

[0059] The difference between the above comparative example and Example 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) was replaced with an equal amount of sodium carboxymethyl cellulose. Comparative Example 2

[0060] Comparative Example 2 provides a polymer denture fixation paste.

[0061] The difference between the above comparative example and Example 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) was replaced with an equal amount of polymethyl vinyl ether-maleic anhydride copolymer. Comparative Example 3

[0062] Comparative Example 3 provides a polymer denture fixation paste.

[0063] The difference between the above comparative example and Example 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) was replaced with an equal amount of sodium carboxymethyl cellulose and polymethyl vinyl ether-maleic anhydride copolymer in a weight ratio of 1:1. Comparative Example 4

[0064] Comparative Example 4 provides a polymer denture fixation paste.

[0065] The difference between the above comparative example and Example 4 is that the polyethylene glycol-polycaprolactone block copolymer (PEG5000-PCL3000) was replaced with an equal amount of polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer PEO100-PPO65-PEO100 (Pluronic F127).

[0066] Performance testing

[0067] The bonding strength of the polymer denture adhesives obtained in Examples 1-12 and Comparative Examples 1-4 was tested, and the results are shown in Table 2 below.

[0068] Standard-sized denture base resin sheets (simulated dentures) were bonded to moist collagen membranes (simulated mucosa) using polymer denture bonding paste. After standing for 5 minutes, test samples were obtained (25 samples were prepared in parallel for each group). One group of test samples was directly peeled off by applying a peeling force, and the maximum peeling force was recorded as the initial bond strength. Then, the other test samples were placed in artificial saliva at 37°C, and a mechanical device was used to simulate periodic light-load chewing movements at a frequency of 1 Hz and a pressure of 5 N for 5 minutes / h. One group of test samples was taken out at 6h, 12h, 18h, and 20h, and their remaining peeling force was tested.

[0069] Note: When the effective adhesion strength of the polymer denture adhesive is >3 N / cm 2 The definition of teeth is that they can fit closely to the gums, thus meeting the needs of daily use.

[0070] Table 2 Performance test results of polymer denture adhesive obtained in Examples 1-12 and Comparative Examples 1-4

[0071] The test results in Table 2 show that the initial bond strength of the polymer denture bonding pastes obtained in Examples 1-12 is 4.7-5.9 N / cm. 2 The bond strength after 6 hours was 4.6-5.7 N / cm. 2 The bond strength after 12 hours was 3.8-5.3 N / cm. 2 (≥3.0 N / cm) 2 The bond strength after 18 hours is 2.6-4.3 N / cm. 2 After 20 hours, the bond strength was 1.8-3.2 N / cm. 2 Therefore, this application demonstrates that the use of polyethylene glycol-polycaprolactone block copolymer and / or catechol-terminated polyethylene glycol-polylactic acid block copolymer as amphiphilic block copolymers to prepare polymeric denture adhesive results in a high-molecular-weight denture adhesive with excellent bonding strength. This adhesive can firmly bridge the denture to the tissue and effectively resist the dissolution and erosion of saliva. Even after 12 hours, the bonding strength still reaches 3.0 N / cm. 2 above.

[0072] The initial bond strength of the polymer denture bonding adhesives obtained in Comparative Examples 1-4 was 4.3-4.6 N / cm. 2 The bond strength after 6 hours was 3.6-4.1 N / cm.2 After 12 hours, the bond strength was only 2.4-2.9 N / cm. 2 (<3.0 N / cm) 2 Therefore, it is evident that the adhesive strength of the polymer denture adhesive prepared by Comparative Examples 1-4 using sodium carboxymethyl cellulose and / or polymethyl vinyl ether-maleic anhydride copolymer, or polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer as the main component, decays rapidly, and its bonding strength fails to meet the usage requirements after 12 hours.

[0073] Although the present invention has been described in detail above with general descriptions and specific embodiments, modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention fall within the scope of protection claimed by the present invention.

Claims

1. A polymer denture bonding paste, characterized in that, It includes the following components in parts by weight: 30-55 parts of amphiphilic block copolymer, 10-25 parts of tackifying resin, 20-35 parts of biocompatible plasticizer, 3-8 parts of thixotropic enhancer and 0.5-5 parts of functional additives; The amphiphilic block copolymer is a mixture of polyethylene glycol-polycaprolactone block copolymer and catechol-terminated polyethylene glycol-polylactic acid block copolymer; the weight ratio of the polyethylene glycol-polycaprolactone block copolymer to the catechol-terminated polyethylene glycol-polylactic acid block copolymer is 1:(0.2-0.5). In the polyethylene glycol-polycaprolactone block copolymer, the number average molecular weight of the polyethylene glycol block is 2000-5000 Da, and the number average molecular weight of the polycaprolactone block is 3000-6000 Da.

2. The polymer denture adhesive according to claim 1, characterized in that, The polymer denture adhesive comprises the following components in parts by weight: 35-50 parts of amphiphilic block copolymer, 15-20 parts of tackifying resin, 25-35 parts of biocompatible shaping agent, 3-8 parts of thixotropic enhancer, and 0.5-5 parts of functional additives.

3. The polymer denture adhesive according to claim 1, characterized in that, The tackifying resin is hydrogenated rosin glycerol ester and / or terpene resin.

4. The polymer denture adhesive according to claim 1, characterized in that, The biocompatible plasticizer is selected from one or more of light mineral oil, polydimethylsiloxane, caprylic triglyceride, and caprylic triglyceride.

5. The polymer denture adhesive according to claim 1, characterized in that, The thixotropic enhancer is nanocrystalline cellulose.

6. The polymer denture adhesive according to any one of claims 1-5, characterized in that, The functional additives are selected from one or more of preservatives, rheology modifiers, humectants, and colorants.

7. The method for preparing the polymer denture adhesive as described in any one of claims 1-6, characterized in that, Includes the following steps: Amphiphilic block copolymer and tackifying resin are dissolved in volatile solvent to obtain a glue solution; then a biocompatible plasticizer and a thixotropic enhancer are added to the glue solution in sequence and dispersed at high speed to obtain a crude paste; the crude paste is heated under vacuum, and finally functional additives are added and stirred evenly to obtain a polymer denture fixation paste.

8. The method for preparing the polymer denture adhesive according to claim 7, characterized in that, The volatile solvent is ethyl acetate or acetone.

9. The use of the polymer denture fixative paste as described in any one of claims 1-6 in the preparation of oral care products for removable dentures.

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