A biomimetic vernix composition, its preparation method and application on nonwoven fabric

Abstract

The present application relates to the technical field of biomimetic vernix caseosa composition, and particularly relates to a biomimetic vernix caseosa composition, a preparation method thereof and application thereof on non-woven fabric. The biomimetic vernix caseosa composition comprises the following mass components: physiological barrier lipid 60-80 parts, emollient protectant 10-20 parts, efficacy agent 3-5 parts, pH value regulator 2-3 parts, deionized water 15-25 parts and reinforcing agent 0-2 parts. The preparation method comprises the following steps: S11. heating and melting physiological barrier lipid in a water bath at 75-80 DEG C to obtain an oil phase; S12. dissolving emollient protectant, reinforcing agent, efficacy agent and pH value regulator in the oil phase; S13. heating deionized water to 75-80 DEG C, shearing to form colostrum; S14. transferring the colostrum to a high-pressure homogenizing device, and homogenizing for 3-5 cycles to obtain the biomimetic vernix caseosa composition. The prepared biomimetic vernix caseosa composition can be applied on non-woven fabric.

Description

Technical Field

[0001] This invention relates to the field of biomimetic vernix caseosa composition technology, and more particularly to a biomimetic vernix caseosa composition, its preparation method, and its application in nonwoven fabrics. Background Technology

[0002] Vernix caseosa, the natural, complex, and highly functional mixture of biolipids on a newborn's skin, is primarily composed of sebaceous gland secretions and epidermal cell degradation products. Its main physiological functions include providing a moisturizing and waterproof barrier in the womb, helping to maintain skin pH after birth, promoting skin barrier maturation, providing antibacterial and anti-inflammatory effects, and reducing friction damage. However, this natural protective layer gradually disappears after birth, exposing the infant's skin to dryness, irritation, and the threat of pathogens.

[0003] Most baby skincare products and wipes on the market currently focus on achieving a single function, such as cleansing, moisturizing, or isolating. Common problems include:

[0004] 1. Simplified composition: Inert sealing agents such as mineral oil and petrolatum are often used, or a single type of oil is added, which is far from the complex lipid composition of natural vernix caseosa and cannot fully simulate its physiological functions.

[0005] 2. One-sided efficacy: It focuses on physical isolation or basic moisturizing, but lacks active repair of the skin barrier, anti-inflammatory and soothing effects, and regulation of the skin's microecological balance.

[0006] 3. Carrier limitations: The liquid formula of traditional wet wipes is mainly a water-based cleaning system. The small amount of lipids or skin care ingredients added are easily absorbed unevenly by the non-woven fabric, or most of them are discarded in the packaging during use. The actual skin absorption rate is low, and it is difficult to form a long-lasting and stable biomimetic lipid film.

[0007] 4. Risk of irritation: To achieve cleaning, preservation and other purposes, surfactants, alcohol, chemical preservatives and other substances are often added. Long-term use may damage the delicate skin barrier of newborns.

[0008] CN116747340B relates to a biomimetic vernix caseosa composition, diapers, and their preparation methods and applications. The provided biomimetic vernix caseosa composition, by weight, comprises the following components: 10-50 parts beeswax, 5-30 parts jojoba wax, 5-30 parts squalane, 1-30 parts ceramide, 1-10 parts bisabolol, 0.1-1 part ethylhexylglycerin, 0.5-10 parts Cnidium monnieri extract, 0.1-10 parts lauryl alcohol, 0.08-1 part capryloyl hydroxamic acid, 0.1-5 parts tocopheryl acetate, and 0.1-1 part citric acid. When the biomimetic vernix caseosa composition is applied to the surface layer of a diaper, it can be transferred to the skin surface through friction between the diaper and the skin to form a hydrophobic oil film, lubricating the diaper fibers and reducing friction; it also allows urine to flow quickly across the skin surface, protecting the stratum corneum while maintaining the skin surface environment in a continuously slightly acidic state, thereby protecting the skin barrier and inhibiting bacterial growth. However, its application scenarios are still limited, and there is still considerable room for improvement in its overall performance.

[0009] Currently, there is a lack of a technical solution that combines specific types and proportions of physiological lipids with effective active ingredients and stably loads them onto nonwoven fabrics through a special process to achieve long-lasting, multi-effect biomimetic barrier repair. Therefore, it is of great significance to develop a composition that can highly mimic the composition and function of natural vernix caseosa and can be applied to a nonwoven fabric carrier in a stable and efficient form. Summary of the Invention

[0010] This invention provides a biomimetic vernix caseosa composition comprising the following components by weight:

[0011] Physiological barrier lipids 60-80 parts, skin moisturizer 10-20 parts, efficacy agent 3-5 parts, pH adjuster 2-3 parts, deionized water 15-25 parts, and enhancer 0-2 parts.

[0012] Furthermore, the enhancer is composed of apple polyphenols and fullerol in a mass ratio of 2:(0~1). The antioxidant free radical scavenging ability of fullerol is coupled with the barrier repair function of ceramide, thereby improving the survival rate of keratinocytes. At the same time, fullerol binds to the hydrophobic tail of ceramide through π-π stacking, and ceramide is embedded in the gaps of the fullerene network to form a "nano-mesh scaffold" that repairs the lipid molecular layer of the stratum corneum.

[0013] Furthermore, the physiological barrier lipids are composed of ceramide EOP, ceramide NP, ceramide AP, cholesterol, and β-sitosterol in a mass ratio of (1~2):(1~2):(1~2):1:(0~1). Ceramides are the main components of intercellular lipids and are crucial for maintaining the integrity of the skin barrier and reducing transepidermal water loss. Different subtypes of ceramides work synergistically to more accurately mimic the natural lipid bilayer structure. Cholesterol and ceramides together form a stable lamellar liquid crystal structure, which is an essential regulator and stabilizer of barrier function. When ceramides and cholesterol are combined in a specific mass ratio, they can spontaneously form a lamellar liquid crystal structure identical to that of healthy skin at a suitable temperature. Compared with a simple mixture of single or two lipids, this biomimetic structure has superior barrier density and stability, and can more effectively lock in water and resist external stimuli. β-Sitosterol's rigid steroidal ring structure is similar to that of cholesterol but has a different spatial configuration. It can be embedded in the lipid bilayer, not only playing an additional stabilizing role like a "rivet", but also forming intermolecular interactions with the amide bonds of ceramides. Together, they construct a denser and more stable layered liquid crystal structure than traditional formulations, thus performing better in reducing transdermal water loss.

[0014] Furthermore, the emollient protectant is composed of deep-sea algal oil, squalane, and phytosterol isostearyl dioleate in a mass ratio of 2:1:1, wherein the deep-sea algal oil contains docosahexaenoic acid (DHA). Squalane is a highly skin-friendly, inert, and stable emollient with a molecular structure similar to squalene in human sebum, allowing for rapid penetration, replenishment of lipids, and non-clogging of pores. DHA in deep-sea algal oil is a key bioactive molecule that may promote the formation of filaggrin, a key protein in the skin barrier. Isostearyl dioleate is a highly effective skin lipid analog and stabilizer, possessing both the emollient properties of sebum and the barrier properties of intercellular lipids. It can embed itself in the replenished lipid layer, significantly enhancing the oxidative stability of the entire system and improving moisturizing and barrier stabilization effects. Synergistically with ceramides, it constructs a "super biomimetic" system that is highly homologous to the lipids of the stratum corneum in both chemical structure and physiological function, achieving precise and efficient barrier repair.

[0015] Furthermore, the active ingredient is composed of bisabolol, tocopheryl acetate, palmitoyl pentapeptide-4, and allantoin in a mass ratio of 2:1:1:1. Bisabolol has clear anti-inflammatory, anti-irritant, and skin-soothing effects, and can neutralize minor irritation that may occur during cleansing. Tocopheryl acetate is a derivative of vitamin E, which is stable, antioxidant, and protects lipid components from oxidation, while also having a soothing effect. Allantoin can promote cell proliferation and repair, and soothe inflammation. Bisabolol and allantoin directly intervene in potential inflammation and damage, complementing the "physical defense" of barrier repair with "active repair." Palmitoyl pentapeptide-4 can repair lipid bilayer defects and form an "anchoring-filling" effect with ceramide NP, increasing the density of the layered structure.

[0016] Furthermore, the pH adjuster is composed of lactic acid and citric acid in a mass ratio of 2:1. The pH adjuster is not simply an addition of acidic components, but rather a carefully selected buffer combination of lactic acid and citric acid. These two components, in a specific ratio, form a pH buffer pair that can gently and persistently stabilize the skin's surface pH within a healthy, slightly acidic range. This provides an ideal physiological environment for the aforementioned lipids and moisturizing ingredients to function, thereby activating the skin's self-repair function as a whole.

[0017] The present invention also provides a method for preparing the above-mentioned biomimetic vernix caseosa composition, comprising the following steps:

[0018] S11. The physiological barrier lipids are heated and melted in a water bath at 75~80℃ and mixed evenly to obtain the oil phase;

[0019] S12. Emollients, protectants, enhancers, efficacy agents and pH adjusters are dissolved in the oil phase;

[0020] S13. Heat deionized water to 75~80℃, and slowly add it to the oil phase under 10000rpm shear to form a primary emulsion;

[0021] S14. Transfer the colostrum to a high-pressure homogenizer and homogenize it 3-5 times under a pressure of 50-80 MPa to obtain a biomimetic vernix caseosa composition.

[0022] The present invention also provides an application of the above-described biomimetic vernix caseosa composition on nonwoven fabric, wherein the biomimetic vernix caseosa composition is loaded onto the nonwoven fabric at a loading amount of 5-50 g / m². 2 The loading method is a hot melt spray-cold pressing shaping process.

[0023] Furthermore, in the application of the biomimetic vernix caseosa composition on nonwoven fabrics, the hot melt spray-cold pressing setting process includes the following steps:

[0024] S21. Heat the biomimetic vernix caseosa composition to a molten state at a temperature of 40-50°C;

[0025] S22. Atomize the molten composition and spray it onto the surface of the nonwoven fabric substrate;

[0026] S23. The sprayed nonwoven fabric is subjected to low-temperature cold pressing to solidify and fix the composition onto the nonwoven fabric. The cold pressing temperature is 5~15℃. The low temperature causes the sprayed liquid composition to solidify rapidly, fixing it at the fiber intersections and fiber surfaces, forming numerous tiny solid or semi-solid lipid particles. This avoids uneven distribution, greasy feel, and leakage during storage caused by excessive penetration and migration of lipids into the fiber interior.

[0027] Compared with the prior art, the present invention has the following significant advantages:

[0028] 1. Highly biomimetic and multifunctional: The composition precisely mimics the core lipid structure and ratio of natural vernix caseosa, providing not only an excellent physical barrier but also multiple bioactivities such as active repair, anti-inflammatory soothing, and antioxidant protection, resulting in comprehensive efficacy.

[0029] 2. Excellent load-bearing stability: Through a unique "hot melt spraying-cold pressing" process, the industry challenge of uniformly and stably loading high-lipid content compositions onto nonwoven fabrics is solved. The resulting product is dry, non-sticky, and has a good hand feel, and its composition remains stable during storage without leakage.

[0030] 3. Immediate and long-lasting effects: When used, the temperature and moisture of the skin cause the solid lipid particles on the non-woven fabric to melt and spread rapidly, releasing active ingredients and forming a continuous, biomimetic protective film on the skin surface that is compatible with the sebum film, resulting in immediate and long-lasting effects.

[0031] 4. High safety: Avoids the use of irritating surfactants, alcohol and chemical preservatives commonly found in traditional wet wipes, making it especially suitable for newborns, sensitive skin and damaged skin. Detailed Implementation

[0032] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0033] Example 1

[0034] A biomimetic vernix caseosa composition comprising the following components by weight: 60 parts of physiological barrier lipids, 16 parts of skin moisturizer, 4 parts of efficacy agent, 2 parts of pH adjuster, and 20 parts of deionized water.

[0035] The physiological barrier lipids are composed of ceramide EOP, ceramide NP, ceramide AP and cholesterol in a mass ratio of 1:1:1:1.

[0036] The skin-protecting agent is composed of deep-sea algae oil, squalane, and phytosterol isostearyl dioleate in a mass ratio of 2:1:1, wherein the deep-sea algae oil contains docosahexaenoic acid.

[0037] The active ingredient is composed of bisabolol, tocopheryl acetate, palmitoyl pentapeptide-4 and allantoin in a mass ratio of 2:1:1:1.

[0038] The pH adjuster is composed of lactic acid and citric acid in a mass ratio of 2:1.

[0039] The preparation method of the above-mentioned biomimetic vernix caseosa composition includes the following steps:

[0040] S11. The physiological barrier lipids are heated and melted in a water bath at 75~80℃ and mixed evenly to obtain the oil phase;

[0041] S12. Emollients, protective agents, functional agents, and pH adjusters are dissolved in the oil phase;

[0042] S13. Heat deionized water to 75~80℃, and slowly add it to the oil phase under 10000rpm shear to form a primary emulsion;

[0043] S14. The colostrum is transferred to a high-pressure homogenizer and homogenized 4 times under a pressure of 62 MPa to obtain a biomimetic vernix caseosa composition.

[0044] The application of the above-mentioned biomimetic vernix caseosa composition on nonwoven fabric is as follows: the biomimetic vernix caseosa composition is loaded onto the nonwoven fabric at a loading amount of 15 g / m². 2 The loading method is a hot melt spray-cold pressing shaping process.

[0045] The hot melt spraying-cold pressing shaping process includes the following steps:

[0046] S21. Heat the biomimetic vernix caseosa composition to a molten state at a temperature of 40-42°C;

[0047] S22. Atomize the molten composition and spray it onto the surface of the nonwoven fabric substrate;

[0048] S23. The sprayed nonwoven fabric is subjected to low-temperature cold pressing to solidify and fix the composition onto the nonwoven fabric, wherein the cold pressing temperature is 10°C.

[0049] Example 2

[0050] A biomimetic vernix caseosa composition comprising the following components by weight: 60 parts of physiological barrier lipids, 16 parts of skin moisturizer, 4 parts of efficacy agent, 2 parts of pH adjuster, and 20 parts of deionized water.

[0051] The physiological barrier lipids are composed of ceramide EOP, ceramide NP, ceramide AP, cholesterol, and β-sitosterol in a mass ratio of 1:1:1:1:1.

[0052] The skin-protecting agent is composed of deep-sea algae oil, squalane, and phytosterol isostearyl dioleate in a mass ratio of 2:1:1, wherein the deep-sea algae oil contains docosahexaenoic acid.

[0053] The active ingredient is composed of bisabolol, tocopheryl acetate, palmitoyl pentapeptide-4 and allantoin in a mass ratio of 2:1:1:1.

[0054] The pH adjuster is composed of lactic acid and citric acid in a mass ratio of 2:1.

[0055] The preparation method of the above-mentioned biomimetic vernix caseosa composition includes the following steps:

[0056] S11. The physiological barrier lipids are heated and melted in a water bath at 75~80℃ and mixed evenly to obtain the oil phase;

[0057] S12. Emollients, protective agents, functional agents, and pH adjusters are dissolved in the oil phase;

[0058] S13. Heat deionized water to 75~80℃, and slowly add it to the oil phase under 10000rpm shear to form a primary emulsion;

[0059] S14. The colostrum is transferred to a high-pressure homogenizer and homogenized 4 times under a pressure of 62 MPa to obtain a biomimetic vernix caseosa composition.

[0060] The application of the above-mentioned biomimetic vernix caseosa composition on nonwoven fabric is as follows: the biomimetic vernix caseosa composition is loaded onto the nonwoven fabric at a loading amount of 15 g / m². 2 The loading method is a hot melt spray-cold pressing shaping process.

[0061] The hot melt spraying-cold pressing shaping process includes the following steps:

[0062] S21. Heat the biomimetic vernix caseosa composition to a molten state at a temperature of 40-42°C;

[0063] S22. Atomize the molten composition and spray it onto the surface of the nonwoven fabric substrate;

[0064] S23. The sprayed nonwoven fabric is subjected to low-temperature cold pressing to solidify and fix the composition onto the nonwoven fabric, wherein the cold pressing temperature is 10°C.

[0065] Example 3

[0066] A biomimetic vernix caseosa composition comprising the following components by weight: 60 parts of physiological barrier lipids, 16 parts of skin moisturizer, 4 parts of efficacy agent, 2 parts of pH adjuster, 1 part of enhancer, and 20 parts of deionized water.

[0067] The enhancer is composed of apple polyphenols and fullerol in a mass ratio of 2:1.

[0068] The physiological barrier lipids are composed of ceramide EOP, ceramide NP, ceramide AP and cholesterol in a mass ratio of 1:1:1:1.

[0069] The skin-protecting agent is composed of deep-sea algae oil, squalane, and phytosterol isostearyl dioleate in a mass ratio of 2:1:1, wherein the deep-sea algae oil contains docosahexaenoic acid.

[0070] The active ingredient is composed of bisabolol, tocopheryl acetate, palmitoyl pentapeptide-4 and allantoin in a mass ratio of 2:1:1:1.

[0071] The pH adjuster is composed of lactic acid and citric acid in a mass ratio of 2:1.

[0072] The preparation method of the above-mentioned biomimetic vernix caseosa composition includes the following steps:

[0073] S11. The physiological barrier lipids are heated and melted in a water bath at 75~80℃ and mixed evenly to obtain the oil phase;

[0074] S12. Emollients, protectants, enhancers, efficacy agents and pH adjusters are dissolved in the oil phase;

[0075] S13. Heat deionized water to 75~80℃, and slowly add it to the oil phase under 10000rpm shear to form a primary emulsion;

[0076] S14. The colostrum is transferred to a high-pressure homogenizer and homogenized 4 times under a pressure of 62 MPa to obtain a biomimetic vernix caseosa composition.

[0077] The application of the above-mentioned biomimetic vernix caseosa composition on nonwoven fabric is as follows: the biomimetic vernix caseosa composition is loaded onto the nonwoven fabric at a loading amount of 15 g / m². 2 The loading method is a hot melt spray-cold pressing shaping process.

[0078] The hot melt spraying-cold pressing shaping process includes the following steps:

[0079] S21. Heat the biomimetic vernix caseosa composition to a molten state at a temperature of 40-42°C;

[0080] S22. Atomize the molten composition and spray it onto the surface of the nonwoven fabric substrate;

[0081] S23. The sprayed nonwoven fabric is subjected to low-temperature cold pressing to solidify and fix the composition onto the nonwoven fabric, wherein the cold pressing temperature is 10°C.

[0082] Example 4

[0083] A biomimetic vernix caseosa composition comprising the following components by weight: 60 parts of physiological barrier lipids, 16 parts of skin moisturizer, 4 parts of efficacy agent, 2 parts of pH adjuster, 1 part of enhancer, and 20 parts of deionized water.

[0084] The enhancer is apple polyphenol.

[0085] The physiological barrier lipids are composed of ceramide EOP, ceramide NP, ceramide AP and cholesterol in a mass ratio of 1:1:1:1.

[0086] The skin-protecting agent is composed of deep-sea algae oil, squalane, and phytosterol isostearyl dioleate in a mass ratio of 2:1:1, wherein the deep-sea algae oil contains docosahexaenoic acid.

[0087] The active ingredient is composed of bisabolol, tocopheryl acetate, palmitoyl pentapeptide-4 and allantoin in a mass ratio of 2:1:1:1.

[0088] The pH adjuster is composed of lactic acid and citric acid in a mass ratio of 2:1.

[0089] The preparation method of the above-mentioned biomimetic vernix caseosa composition includes the following steps:

[0090] S11. The physiological barrier lipids are heated and melted in a water bath at 75~80℃ and mixed evenly to obtain the oil phase;

[0091] S12. Emollients, protectants, enhancers, efficacy agents and pH adjusters are dissolved in the oil phase;

[0092] S13. Heat deionized water to 75~80℃, and slowly add it to the oil phase under 10000rpm shear to form a primary emulsion;

[0093] S14. The colostrum is transferred to a high-pressure homogenizer and homogenized 4 times under a pressure of 62 MPa to obtain a biomimetic vernix caseosa composition.

[0094] The application of the above-mentioned biomimetic vernix caseosa composition on nonwoven fabric is as follows: the biomimetic vernix caseosa composition is loaded onto the nonwoven fabric at a loading amount of 15 g / m². 2 The loading method is a hot melt spray-cold pressing shaping process.

[0095] The hot melt spraying-cold pressing shaping process includes the following steps:

[0096] S21. Heat the biomimetic vernix caseosa composition to a molten state at a temperature of 40-42°C;

[0097] S22. Atomize the molten composition and spray it onto the surface of the nonwoven fabric substrate;

[0098] S23. The sprayed nonwoven fabric is subjected to low-temperature cold pressing to solidify and fix the composition onto the nonwoven fabric, wherein the cold pressing temperature is 10°C.

[0099] Comparative Example 1

[0100] The only difference is that the components ceramide EOP, ceramide NP, and ceramide AP in Example 1 are all replaced with ceramide EOP. The rest is the same as in Example 1, and will not be repeated here.

[0101] Comparative Example 2

[0102] The only difference is that the component phytosterol isostearyl alcohol dimer linoleate in Example 1 is replaced with squalane. Everything else is the same as in Example 1, and will not be repeated here.

[0103] Comparative Example 3

[0104] The only difference is that the component palmitoyl pentapeptide-4 in Example 1 is replaced with tocopherol acetate; otherwise, it is the same as in Example 1 and will not be repeated.

[0105] Comparative Example 4

[0106] The only difference is that the cold pressing temperature of the component in step S23 of Example 1 is changed from 10°C to 25°C. Everything else is the same as in Example 1, and will not be repeated here.

[0107] Comparative Example 5

[0108] Commercially available nonwoven fabric.

[0109] Table 1 shows the results of performance tests on the biomimetic vernix caseosa compositions prepared according to the embodiments and comparative examples of the present invention and their application on nonwoven fabrics.

[0110] 1. Transdermal water loss (TEWL) reduction rate: Using an artificial skin membrane, the barrier function was first damaged with SLS (sodium lauryl sulfate) (simulating stimulation), and then treated with different samples. The reduction in transdermal water loss (TEWL) after treatment (after 24 hours) was measured. The greater the reduction in TEWL, the better the barrier repair effect.

[0111] 2. Skin feel evaluation: 100 healthy adult volunteers will be recruited to evaluate whether the product is greasy when applied, whether it dries easily, and whether the skin feels soft and moisturized after use.

[0112] 3. Skin stratum corneum moisture content enhancement rate: 100 healthy adult volunteers (inner arm skin) were recruited. Each sample was used to wipe a fixed area twice a day for 7 consecutive days to test the skin stratum corneum moisture content.

[0113] 4. The coefficient of kinetic friction of the nonwoven fabrics prepared according to the embodiments and comparative examples of the present invention was tested in accordance with GB / T22895-2008.

[0114] 5. Antioxidant value was determined in accordance with GB5009.227-2016.

[0115] Table 1

[0116] TEWL reduction rate, % Excellent skin feel rating, % Skin stratum corneum moisture content increase rate, % coefficient of kinetic friction Antioxidant value, mmol / kg Example 1 42.5 86 28.2 0.34 1.52 Example 2 43.1 88 29.2 0.32 1.51 Example 3 46.2 92 31.2 0.29 1.38 Example 4 45.1 90 30.3 0.30 1.40 Comparative Example 1 41.5 81 26.8 0.36 1.63 Comparative Example 2 42.1 82 26.9 0.34 1.55 Comparative Example 3 40.9 79 25.2 0.32 1.69 Comparative Example 4 42.2 85 28.1 0.41 1.51 Comparative Example 5 / / / 0.58 /

[0117] As can be seen from the data in Table 1 above, in Examples 1, 2, 3, and 4, the increase of the β-sitosterol component, the enhancer, and the synergistic effect among the enhancers all contribute to improving product performance. Data from Comparative Example 1 shows that the product prepared from a single ceramide has a slightly decreased performance; data from Comparative Example 2 shows that the synergistic effect among the emollients and protectants can improve product performance; data from Comparative Example 3 shows that the lack of synergistic effect from palmitoyl pentapeptide-4 leads to a decrease in product performance; data from Comparative Example 4 shows that the preparation method has a significant impact on the product's application performance, especially the coefficient of kinetic friction.

Claims

1. A biomimetic vernix caseosa composition, characterized in that, A substance composed of the following mass components: Physiological barrier lipids 60-80 parts, skin moisturizer 10-20 parts, efficacy agent 3-5 parts, pH adjuster 2-3 parts, deionized water 15-25 parts and enhancer 1-2 parts; The physiological barrier lipids are composed of ceramide EOP, ceramide NP, ceramide AP, cholesterol and β-sitosterol in a mass ratio of (1~2):(1~2):(1~2):1:1; The enhancer is composed of apple polyphenols and fullerol in a mass ratio of 2:1; The preparation method of the biomimetic vernix caseosa composition includes the following steps: S11. The physiological barrier lipids are heated and melted in a water bath at 75~80℃ and mixed evenly to obtain the oil phase; S12. Emollients, protectants, enhancers, efficacy agents, and pH adjusters are dissolved in the oil phase; S13. Heat deionized water to 75~80℃, and slowly add it to the oil phase under 10000rpm shear to form a primary emulsion; S14. Transfer the colostrum to a high-pressure homogenizer and homogenize it 3 to 5 times under a pressure of 50 to 80 MPa to obtain a biomimetic vernix caseosa composition. The biomimetic vernix caseosa composition is applied to nonwoven fabrics, wherein the biomimetic vernix caseosa composition is loaded onto the nonwoven fabric at a loading rate of 5-50 g / m². 2 The loading method is a hot melt spraying-cold pressing shaping process, which includes the following steps: S21. Heat the biomimetic vernix caseosa composition to a molten state at a temperature of 40-50°C; S22. Atomize the molten composition and spray it onto the surface of the nonwoven fabric substrate; S23. The sprayed nonwoven fabric is subjected to low-temperature cold pressing to solidify and fix the composition onto the nonwoven fabric, wherein the cold pressing temperature is 5~15℃. The skin-protecting agent is composed of deep-sea algae oil, squalane and phytosterol isostearyl dioleate in a mass ratio of 2:1:1, wherein the deep-sea algae oil contains docosahexaenoic acid. The active ingredient is composed of bisabolol, tocopheryl acetate, palmitoyl pentapeptide-4 and allantoin in a mass ratio of 2:1:1:

1.

2. The biomimetic vernix caseosa composition according to claim 1, characterized in that, The pH adjuster is composed of lactic acid and citric acid in a mass ratio of 2:1.