A combined testing and analysis device for coagulation and platelet function

Abstract

This invention relates to a combined testing and analysis device for coagulation and platelet function, belonging to the field of medical testing technology. It includes a centrifuge and a turbidimeter arranged opposite each other, a vertical frame positioned between the centrifuge and the turbidimeter, a horizontally rotating suspension mounted in the middle of the vertical frame, a multi-tube blood collection tube vertically inserted into the suspension, a waste liquid collection assembly positioned on one side of the centrifuge and the turbidimeter, an aggregation inducing agent addition assembly positioned on the other side of the centrifuge and the turbidimeter, and a clamping assembly positioned at the top of the vertical frame. The clamping assembly clamps and moves the blood collection tubes into the centrifuge, the turbidimeter, the waste liquid collection assembly, and the aggregation inducing agent addition assembly. Its advantages include reduced manual intervention and error rate when testing platelet function using turbidimetry, making the process more convenient and accurate.

Description

Technical Field

[0001] This invention relates to the field of medical testing technology, and in particular to a combined testing and analysis device for coagulation and platelet function. Background Technology

[0002] Platelets are the smallest anucleated cell fragments in mammalian blood, formed from the shedding of megakaryocytes from the bone marrow. Platelets are small pieces of cytoplasm detached from the cytoplasm of mature megakaryocytes in the bone marrow. Although megakaryocytes are the fewest number of hematopoietic cells in the bone marrow, accounting for only 0.05% of the total number of nucleated cells, the platelets they produce are extremely important for the body's hemostatic function. When blood is lost due to vascular trauma, the functional activity of platelets in the physiological hemostasis process can be roughly divided into two stages: the first stage mainly involves platelets rapidly adhering to the wound site after the injury occurs and aggregating to form a relatively soft hemostatic plug; the second stage mainly involves promoting blood clotting and forming a firm hemostatic plug.

[0003] The main functions of platelets are blood clotting and hemostasis, and repairing damaged blood vessels. The glycocoating coating on the surface of platelets can adsorb plasma proteins and coagulation factor III, and platelet granules contain substances related to coagulation. When blood vessels are damaged or ruptured, platelets are stimulated, changing from a resting phase to a functional phase, rapidly deforming, increasing surface viscosity, and agglomerating into clumps. Simultaneously, under the influence of surface factor III, prothrombin in the plasma is converted into thrombin, which in turn catalyzes fibrinogen into filamentous fibrin, forming a blood clot with blood cells to stop bleeding. The release of substances from platelet granules further promotes hemostasis and clotting.

[0004] Platelet function testing commonly involves platelet aggregation. This test uses platelet aggregation inducers to induce platelet aggregation, and then measures and calculates the proportion of aggregated platelets. A common method is the transilluminance turbidimetric assay (LTA). The principle is that platelet-rich plasma (PRP) is a relatively opaque cell suspension; after platelet aggregation, its transmittance increases. By measuring changes in the transmittance of PRP samples, platelet function can be analyzed. Under the influence of various aggregation inducers, platelet aggregation occurs in PRP, leading to a decrease in turbidity and an increase in transmittance (the transmittance of platelet-poor plasma (PPP) samples is set to 100%). Therefore, LTA can measure the dynamic changes in platelet aggregation in real time (expressed as a percentage).

[0005] When testing platelet function using the transmittance turbidimetric method, platelet-rich plasma needs to be separated from the blood first. The separation process requires two centrifugations and waste removal. Then, an aggregation inducer is added to the platelet-rich plasma, followed by continuous transmittance testing and recording of the transmittance. The entire process requires very careful operation by the operator and is complicated. Any operational error will result in the platelet-rich plasma being unusable or the test results being incorrect. Summary of the Invention

[0006] (a) Technical problems to be solved

[0007] In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides a combined testing and analysis device for coagulation and platelet function, which solves the technical problem of high error rate when testing platelet function by transmittance turbidimetry.

[0008] (II) Technical Solution

[0009] To achieve the above objectives, the main technical solutions adopted by the present invention include:

[0010] This invention provides a combined testing and analysis device for coagulation and platelet function, comprising a centrifuge and a turbidimeter arranged opposite to each other, a vertical frame vertically disposed between the centrifuge and the turbidimeter, a placement suspension horizontally rotatably disposed in the middle of the vertical frame, a multi-tube blood collection tube vertically inserted into the placement suspension, a waste liquid collection assembly disposed on one side of the centrifuge and the turbidimeter, an aggregation inducing agent addition assembly disposed on the other side of the centrifuge and the turbidimeter, and a clamping assembly disposed on the top of the vertical frame. The clamping assembly clamps the blood collection tube and moves it into the centrifuge, the turbidimeter, the waste liquid collection assembly, and the aggregation inducing agent addition assembly.

[0011] This invention provides a combined coagulation and platelet function testing and analysis device. When using this device, blood is directly collected into a blood collection tube, which is then inserted directly into a suspension frame. The tube is clamped by a clamping assembly and centrifuged for the first centrifugation. During this process, the blood in the blood collection tube separates into layers. The tube is then clamped by the clamping assembly to a waste liquid collection assembly to remove the lower layer of waste liquid. The tube is then clamped again and centrifuged a second time. After centrifugation, waste liquid is removed again, leaving only platelet-rich plasma in the blood collection tube. The tube is then clamped by the clamping assembly to an aggregation inducing agent addition assembly for adding aggregation inducing agent. Finally, the tube is clamped into a transilluminance turbidimeter for continuous transluminance testing. This method reduces manual intervention and error rate when testing platelet function using transilluminance turbidimetry, making it more convenient, faster, and more accurate.

[0012] Optionally, it also includes a sealing cover disposed outside the centrifuge, the transmittance turbidimeter, the waste liquid collection assembly and the aggregation inducer addition assembly, wherein a constant temperature base is provided at the bottom of the sealing cover, and the constant temperature base has a built-in refrigeration device for blowing cold air into the sealing cover.

[0013] By setting up a sealed enclosure, a more sterile environment is provided for the combined testing and analysis of platelet function. At the same time, the constant temperature base at the bottom allows the sealed enclosure to maintain a certain temperature, thereby making the test and analysis results more accurate.

[0014] Optionally, the placement suspension has four blood collection tubes evenly spaced circumferentially, and the centrifugation device and the light transmittance turbidimeter are each provided with four sets of centrifugation stations and light transmittance stations for the simultaneous insertion of the four blood collection tubes.

[0015] By inserting four blood collection tubes into the suspension, the four tubes can be moved, centrifuged, and exposed to light simultaneously, thus completing the testing and analysis of four tubes of platelet-rich plasma in one go, thereby improving the efficiency of testing and analysis.

[0016] Optionally, a light-transmitting cylinder is vertically arranged at the center of the transmissivity turbidimeter, and a long light source is vertically arranged inside the light-transmitting cylinder. The transmissivity turbidimeter has four sets of fan-shaped blocks on the outer periphery of the light-transmitting cylinder, and a long light-transmitting station is formed between adjacent blocks. A long light-transmitting hole is vertically opened at the periphery of the light-transmitting cylinder and communicates with the light-transmitting station. A photosensitive reaction plate is provided at the end of the light-transmitting station away from the light-transmitting cylinder to receive light passing through the blood collection tube and to detect the light transmittance.

[0017] A long light source located in the center of the light-transmitting tube shines a parallel beam of light through the light-transmitting hole into the light-transmitting station. This allows the same light source to illuminate the four light-transmitting stations on the periphery, enabling four sets of blood collection tubes to be inserted into the four light-transmitting stations simultaneously for light transmittance testing and analysis. At the same time, the same light source irradiates the four sets of blood collection tubes simultaneously, allowing for comparison of the platelet-rich plasma inside.

[0018] Optionally, a positioning slot with a horizontal cross-section in the shape of an arc is vertically opened at one end of the adjacent blocks that are close to each other and on the side of the light-transmitting tube, and the side end of the blood collection tube is inserted into the positioning slot.

[0019] By creating positioning slots at the ends of adjacent blocks that are close to each other, the blood collection tube can be inserted vertically into the light-transmitting space. This allows the two ends of the blood collection tube to be inserted into the positioning slots on both sides. On the one hand, the positioning slots provide more stable positioning for the blood collection tube. On the other hand, the blocks shield the curved edges of the blood collection tube on both sides, reducing the impact of the halo generated by the non-directly shining transparent curved surface on the transmitted light, thus obtaining the most accurate test and analysis results.

[0020] Optionally, the blood collection tube includes an inner tube and an outer tube. The inner tube is vertically inserted into the outer tube. A drainage microtube is vertically arranged at the lower end of the inner tube. Large fins are horizontally arranged on both sides of the top of the outer tube. A groove is horizontally opened on the upper surface of the large fins near the outer tube. Small fins are horizontally arranged on both sides of the top of the inner tube and embedded in the groove. Large and small magnetic metal points are embedded in the top of the large and small fins. A cap is detachably inserted into the top of the inner tube. A top magnetic metal point is embedded in the top of the cap.

[0021] By configuring the blood collection tube with an inner cannula and an outer cannula, the inner cannula is vertically inserted into the outer cannula, and a drainage microtube is vertically installed at the lower end of the inner cannula. This allows the inner cannula to be inserted into the outer cannula during centrifugation, light transmission, and the addition of aggregation inducing agents. When removing waste liquid, the inner cannula can be directly removed. Plasma has a high viscosity, and it is difficult to remove directly through the drainage microtube under gravity. However, the outer cannula provides protection and ensures that the plasma will not leak, making it safer. At the same time, a large burr is horizontally installed at the top of the outer cannula, allowing it to be directly inserted into the suspension. Furthermore, the large magnetic attraction metal point, small magnetic attraction metal point, and top magnetic attraction metal point make it easier to magnetically separate the outer cannula, inner cannula, and cap, making it more convenient.

[0022] Optionally, the waste liquid collection assembly includes a waste liquid collection rack with the inner sleeve vertically inserted and fixed, a drain rack vertically slidably disposed above the waste liquid collection rack, four drain push rods vertically disposed on the drain rack that move synchronously with the drain rack and are inserted into the inner sleeve, and a liquid receiving beaker disposed below the waste liquid collection rack.

[0023] After opening the cap using the clamping assembly and vertically removing the inner sleeve, the inner sleeve is directly inserted vertically into the waste liquid collection rack. Then, the drain rack is moved vertically downwards, causing the drain rack to drive four sets of drain push rods directly into the inner sleeve. Under pressure, the waste liquid in layers at the lower end of the inner sleeve will be discharged along the drain microtube. The discharged waste liquid will be collected in a receiving beaker. This solution abandons the traditional method of extracting the upper platelet-rich plasma with a syringe for use, and instead directly discharges the lower waste liquid, which is more convenient.

[0024] Optionally, the clamping assembly includes a clamping shaft that is vertically rotatably connected to the top of the vertical frame, a first adsorption head that is vertically slidably disposed on the side end of the clamping shaft to magnetically adsorb the cap, a second adsorption head that is horizontally slidably connected and vertically slidably disposed on the side end of the clamping shaft, and a third adsorption head, wherein the second adsorption head magnetically adsorbs the small magnetic metal point, and the third adsorption head magnetically adsorbs the large magnetic metal point.

[0025] The rotating clamping shaft drives the first, second, and third adsorption heads on the periphery to rotate and change positions. The first adsorption head can magnetically attract the cap and move vertically, the second adsorption head can magnetically attract the inner sleeve and move horizontally and vertically, and the third adsorption head can magnetically attract the outer sleeve and move horizontally and vertically. In conjunction with the clamping shaft, the entire blood collection tube is moved into the centrifuge and turbidimeter. The cap is opened and the inner sleeve is moved to the waste liquid collection component. Opening the cap allows the aggregation inducer to be added into the inner sleeve. This design allows the clamping component to move the blood collection tube more quickly and accurately, making it more convenient.

[0026] Optionally, the placement suspension has four insertion holes that are vertically and evenly spaced in the circumferential direction. The upper end surface of the placement suspension has fixed grooves on both sides of the insertion holes for the large flash to be inserted. The lower end of the placement suspension has a support frame that supports the lower end of the blood collection tube at an incline on both sides of the insertion holes.

[0027] By creating insertion holes and setting slots on the suspension, the blood collection tube is vertically inserted into the insertion holes, and the large burr on the outer sleeve will be embedded in the setting slot, thus initially positioning the blood collection tube. At this time, the support frame at the lower end of the suspension will support the lower end of the blood collection tube, thereby completing the fixation of the blood collection tube. This solution makes the blood collection tube more stable when moving.

[0028] Optionally, the aggregation inducer addition assembly includes an addition frame horizontally connected to one side of the vertical frame and bent vertically upward at the other end, an addition support plate horizontally disposed on the top of the addition frame, a plurality of addition needles vertically inserted into the addition support plate and having aggregation inducer drawn inside, and a pusher plate vertically slidably disposed on the upper side of the addition support plate and pushing the addition needles downward to squeeze out the aggregation inducer.

[0029] By vertically inserting a syringe containing a certain amount of aggregation inducer onto the addition support plate, and then vertically sliding the push plate so that the push plate abuts against the top of the addition syringe, when the suspension rotates to move the blood collection tube to the underside of the addition syringe, the push plate continues to move downward, causing the push plate to push the addition syringe to squeeze the aggregation inducer into the blood collection tube, thus completing the addition of the aggregation inducer.

[0030] (III) Beneficial Effects

[0031] The beneficial effects of this invention are as follows: The combined coagulation and platelet function testing and analysis device of this invention, when used, directly collects blood into a blood collection tube, then inserts the blood collection tube directly into a suspension frame, and clamps the blood collection tube into a centrifuge for the first centrifugation. At this time, the blood in the blood collection tube separates into layers. The blood collection tube is then clamped into a waste liquid collection component to remove the lower layer of waste liquid. The blood collection tube is then clamped into a centrifuge for a second centrifugation. After centrifugation, waste liquid is removed again, leaving only platelet-rich plasma in the blood collection tube. The blood collection tube is then clamped into an aggregation inducing agent addition component to add aggregation inducing agent. Finally, the blood collection tube is clamped into a transilluminance turbidimeter for continuous transluminance testing. This method reduces manual intervention and error rate when testing platelet function by transilluminance turbidimetry, making it more convenient, faster, and more accurate. Attached Figure Description

[0032] Figure 1 This is a three-dimensional exploded view of an embodiment of the present invention;

[0033] Figure 2 This is a cross-sectional view of an embodiment of the present invention;

[0034] Figure 3 This is a schematic diagram of the transmittance turbidimeter in an embodiment of the present invention;

[0035] Figure 4 This is a schematic diagram of an explosion of a blood collection tube in an embodiment of the invention;

[0036] Figure 5 This is a schematic diagram of the structure for placing the suspension in an embodiment of the invention.

[0037] [Explanation of Labels in the Attached Image]

[0038] 1. Constant temperature base; 11. Refrigeration device; 12. Sealing cover; 2. Centrifuge equipment; 21. Centrifuge station; 3. Transmittance turbidimeter; 31. Light transmission station; 32. Light transmission tube; 33. Long strip light source; 34. Stop block; 341. Positioning slot; 35. Light transmission hole; 36. Photosensitive reaction plate; 4. Vertical frame; 5. Placement suspension; 51. Insertion hole; 52. Fixed slot; 53. Support frame; 6. Blood collection tube; 61. Inner sleeve; 611. Drainage microtube; 612. Small burr; 613. Small magnetic metal point; 62. Outer tube; 621. Large flash; 622. Embedded groove; 623. Large magnetic metal point; 63. Cap; 631. Top magnetic metal point; 7. Waste liquid collection assembly; 71. Waste liquid collection rack; 72. Drain rack; 73. Drain push rod; 74. Receiving beaker; 8. Aggregation inducer addition assembly; 81. Addition rack; 82. Addition support plate; 83. Addition syringe; 84. Push plate; 9. Clamping assembly; 91. Clamping shaft; 92. First adsorption head; 93. Second adsorption head; 94. Third adsorption head. Detailed Implementation

[0039] To better explain and facilitate understanding of the present invention, the present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.

[0040] The coagulation and platelet function combined testing and analysis device proposed in this invention involves directly collecting blood into a blood collection tube, inserting the tube directly into a suspension frame, and clamping it into a centrifuge for the first centrifugation. During this process, the blood in the blood collection tube separates into layers. The tube is then clamped to a waste liquid collection component to remove the lower layer of waste liquid. The tube is then clamped again into the centrifuge for a second centrifugation. After centrifugation, waste liquid is removed again, leaving only platelet-rich plasma in the blood collection tube. The tube is then clamped to an aggregation inducing agent addition component for adding aggregation inducing agent. Finally, the tube is clamped into a transilluminance turbidimeter for continuous transluminance testing. This method reduces manual intervention and error rate when testing platelet function using transilluminance turbidimetry, making it more convenient, faster, and more accurate.

[0041] To better understand the above technical solutions, exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although exemplary embodiments of the present invention are shown in the drawings, it should be understood that the present invention can be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that the present invention can be understood more clearly and thoroughly, and that the scope of the present invention can be fully conveyed to those skilled in the art.

[0042] Reference Figure 1 and Figure 2A combined coagulation and platelet function testing and analysis device includes a horizontally arranged constant temperature base 1, a centrifuge 2 and a transmittance turbidimeter 3 arranged opposite each other on the upper end of the constant temperature base 1, a vertical frame 4 vertically arranged between the centrifuge 2 and the transmittance turbidimeter 3, a horizontally rotating placement suspension 5 in the middle of the vertical frame 4, a multi-tube blood collection tube 6 vertically inserted on the placement suspension 5, a waste liquid collection assembly 7 arranged on one side of the centrifuge 2 and the transmittance turbidimeter 3, an aggregation inducing agent addition assembly 8 arranged on the other side of the centrifuge 2 and the transmittance turbidimeter 3, a clamping assembly 9 arranged on the top of the vertical frame 4, and a sealing cover 12 arranged on the outside of the centrifuge 2, the transmittance turbidimeter 3, the waste liquid collection assembly 7 and the aggregation inducing agent addition assembly 8.

[0043] When using this device, blood is directly collected into the blood collection tube 6, which is then directly inserted into the suspension bracket 5. The blood collection tube 6 is clamped into the centrifuge 2 by the clamping assembly 9 for the first centrifugation. At this time, the blood in the blood collection tube 6 separates into layers. The blood collection tube 6 is then clamped into the waste liquid collection assembly 7 by the clamping assembly 9 to remove the lower layer of waste liquid. The blood collection tube 6 is then clamped into the centrifuge 2 for a second centrifugation. After centrifugation, the waste liquid is removed again, leaving only platelet-rich plasma in the blood collection tube 6. The blood collection tube 6 is then clamped into the aggregation inducing agent addition assembly 8 by the clamping assembly 9 to add the aggregation inducing agent. Finally, the blood collection tube 6 is clamped into the transmittance turbidimeter 3 for continuous transmittance testing.

[0044] The thermostatic base 1 has a built-in cooling device 11 that blows cold air into the sealed cover 12. The sealed cover 12 provides a more sterile environment for the combined testing and analysis of platelet function. At the same time, in conjunction with the thermostatic base 1 at the bottom, the sealed cover 12 can maintain a certain temperature, which is lower than room temperature, thereby making the test and analysis results more accurate.

[0045] See Figure 1 and Figure 5 The suspension frame 5 has four blood collection tubes 6 evenly spaced circumferentially. The centrifuge 2 and the turbidimeter 3 each have four centrifugation stations 21 and light transmission stations 31 for simultaneous insertion of the four blood collection tubes 6. This allows the four blood collection tubes 6 to be moved, centrifuged, and transmitted simultaneously, thus completing the analysis of four tubes of platelet-rich plasma in one operation, thereby improving the efficiency of the analysis.

[0046] See Figure 3A light-transmitting cylinder 32 is vertically installed at the center of the transmissivity turbidimeter 3. A long light source 33 is vertically installed inside the light-transmitting cylinder 32. Four sets of fan-shaped blocks 34 are arranged on the outer periphery of the light-transmitting cylinder 32, forming a long light-transmitting station 31 between adjacent blocks 34. A long light-transmitting hole 35 is vertically opened on the periphery of the light-transmitting cylinder 32 and connects to the light-transmitting station 31. A photosensitive reaction plate 36 is provided at the end of the light-transmitting station 31 away from the light-transmitting cylinder 32 to receive light passing through the blood collection tube 6 and to detect the transmittance. A horizontally arc-shaped positioning slot 341 is vertically opened at the end of the adjacent blocks 34 that are close to each other and on the side close to the light-transmitting cylinder 32. The side part of the blood collection tube 6 is inserted into the positioning slot 341. A long light source 33 located in the central light-transmitting tube 32 illuminates a parallel beam of light into the light-transmitting station 31 through the light-transmitting hole 35. This allows the same light source to illuminate the four surrounding light-transmitting stations 31, enabling four sets of blood collection tubes 6 to be simultaneously inserted into the four light-transmitting stations 31 for transmittance testing and analysis. Simultaneous illumination by the same light source at the same time also allows for comparison of the platelet-rich plasma within the four sets of blood collection tubes 6 being tested simultaneously. The two ends of the blood collection tubes 6 are inserted into positioning slots 341 on both sides. The positioning slots 341 provide better positioning and stability for the blood collection tubes 6. Furthermore, the blocks 34 shield the curved edges of the blood collection tubes 6 on both sides, reducing the impact of halo effects from non-directly illuminating the transparent curved surface on the transmitted light, thus obtaining the most accurate testing and analysis results.

[0047] See Figure 4 The blood collection tube 6 includes an inner tube 61 and an outer tube 62. The inner tube 61 is vertically inserted into the outer tube 62. A drainage microtube 611 is vertically installed at the lower end of the inner tube 61. Large burrs 621 are integrally installed horizontally on both sides of the top of the outer tube 62. A groove 622 is horizontally opened on the upper surface of the large burrs 621 on the side close to the outer tube 62. Small burrs 612 are integrally installed horizontally on both sides of the top of the inner tube 61 and embedded in the groove 622. Large magnetic metal points 623 and small magnetic metal points 613 are embedded in the top of the large burrs 621 and the small burrs 612. A cap 63 is detachably inserted into the top of the inner tube 61. A top magnetic metal point 631 is embedded in the top of the cap 63. This design allows the inner tube 61 to be inserted into the outer tube 62 during centrifugation, light transmission, and the addition of aggregation inducing agents. When draining waste liquid, the inner tube 61 can be directly removed. Plasma has a high viscosity, and it is difficult for plasma to be directly drained through the drainage microtube 611 under the action of gravity. However, the outer tube 62 provides protection and ensures that the plasma will not leak, making it safer.

[0048] See Figure 2The waste liquid collection assembly 7 includes a waste liquid collection rack 71 that is fixed to the upper end of the constant temperature base 1 by bolts and for the inner sleeve 61 to be vertically inserted and fixed; a drain rack 72 that is vertically slidably disposed above the waste liquid collection rack 71 by a cylinder; four sets of drain push rods 73 that are vertically disposed on the drain rack 72 and move synchronously with the drain rack 72 and are inserted into the inner sleeve 61; and a liquid receiving beaker 74 disposed below the waste liquid collection rack 71. The inner sleeve 61 is directly and vertically inserted into the waste liquid collection rack 71. Then, the drain rack 72 is moved vertically downward, causing the drain rack 72 to drive four sets of drain push rods 73 to directly insert into the inner sleeve 61. Under pressure, the waste liquid in layers at the lower end of the inner sleeve 61 will be discharged along the drain microtube 611. The discharged waste liquid will be collected in the receiving beaker 74. A camera is fixed to the side of the waste liquid collection rack 71 by bolts. The camera is located on the upper side of the receiving beaker 74 and takes a horizontal picture of the inserted inner sleeve 61 to determine the layered position of platelet-rich plasma in the inner sleeve 61. The movement of the drain rack 72 is controlled by a built-in chip inside the camera that is connected to the electrical signal and controls the vertical movement of the drain rack 72, thereby achieving accurate discharge of waste liquid.

[0049] See Figure 4 and Figure 5 The clamping assembly 9 includes a clamping shaft 91 with a vertical shaft and driven by a motor to rotate and be connected to the top of the vertical frame 4; a first adsorption head 92 that is vertically slidable on the side of the clamping shaft 91 by a cylinder to magnetically adsorb the cover 63; a second adsorption head 93 and a third adsorption head 94 that are horizontally slidable connected by two sets of cylinders and vertically slidable on the side of the clamping shaft 91; the second adsorption head 93 magnetically adsorbs small magnetic metal points 613; and the third adsorption head 94 magnetically adsorbs large magnetic metal points 623. The rotating clamping shaft 91 drives the first adsorption head 92, the second adsorption head 93, and the third adsorption head 94 at the peripheral end to rotate and change position. The first adsorption head 92 can magnetically attract the cap 63 and move vertically. The second adsorption head 93 can magnetically attract the inner sleeve 61 and move in both horizontal and vertical directions. The third adsorption head 94 can magnetically attract the outer sleeve 62 and move in both horizontal and vertical directions. In conjunction with the clamping shaft 91, the entire blood collection tube 6 is driven into the centrifuge 2 and the turbidimeter 3. The cap 63 is opened and the inner sleeve 61 is moved to the waste liquid collection assembly 7. Opening the cap 63 allows the aggregation inducer to be added into the inner sleeve 61.

[0050] The placement suspension 5 is rotatably connected to the vertical frame 4 via a motor drive. The placement suspension 5 has four vertically arranged insertion holes 51 evenly spaced circumferentially. The upper surface of the placement suspension 5 has grooves 52 on both sides of the insertion holes 51 for the large burr 621 to be inserted. The lower end of the placement suspension 5 has support frames 53 inclined on both sides of the insertion holes 51 to support the lower end of the blood collection tube 6. After the blood collection tube 6 is vertically inserted into the insertion hole 51, the large burr 621 on the outer sleeve 62 will be inserted into the groove 52, thus initially positioning the blood collection tube 6. At this time, the support frames 53 at the lower end of the placement suspension 5 will support the lower end of the blood collection tube 6, thereby completing the fixation of the blood collection tube 6 and making it more stable when moving the blood collection tube 6.

[0051] See Figure 2 The aggregation inducer addition assembly 8 includes a cylinder horizontally fixed to the side of the vertical frame 4 by bolts, an addition frame 81 horizontally connected to the end of the cylinder piston rod and bent vertically upward at the other end, an addition support plate 82 horizontally welded to the top of the addition frame 81, multiple addition needles 83 vertically inserted into the addition support plate 82 and containing aggregation inducers, and a push plate 84 vertically slidable on the upper side of the addition support plate 82 by the cylinder and pushing the addition needles 83 downward to squeeze out the aggregation inducers. The addition needles 83 containing a certain amount of aggregation inducers are vertically inserted into the addition support plate 82. Then, the push plate 84 slides vertically so that it abuts against the top of the addition needles 83. When the suspension 5 rotates to move the blood collection tube 6 to the underside of the addition needles 83, the push plate 84 continues to move downward, pushing the addition needles 83 to squeeze the aggregation inducers into the blood collection tube 6.

[0052] In the description of this invention, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0053] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0054] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first and second features are in direct contact, or that they are in indirect contact through an intermediate medium. Furthermore, "above," "over," or "on top" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," or "beneath" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0055] In the description of this specification, the terms "one embodiment," "some embodiments," "embodiment," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0056] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make modifications, alterations, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A combined testing and analysis device for coagulation and platelet function, characterized in that: The system includes a centrifuge (2) and a turbidimeter (3) arranged in opposite directions, a vertical frame (4) vertically positioned between the centrifuge (2) and the turbidimeter (3), a horizontally rotating suspension (5) positioned in the middle of the vertical frame (4), a multi-tube blood collection tube (6) vertically inserted into the suspension (5), a waste liquid collection assembly (7) positioned on one side of the centrifuge (2) and the turbidimeter (3), and other components positioned between the centrifuge (2) and the turbidimeter (3). The aggregation inducing agent addition component (8) on one side and the clamping component (9) set on the top of the vertical frame (4) clamp the blood collection tube (6) and move it into the centrifuge (2), the light transmittance turbidimeter (3), the waste liquid collection component (7) and the aggregation inducing agent addition component (8). The placement suspension (5) has four blood collection tubes (6) evenly spaced around the circumference. The centrifuge (2) and the light transmittance turbidimeter (3) are each provided with four sets of four blood collection tubes. The centrifugation station (21) and the light transmission station (31) for synchronous insertion of blood vessels (6) are provided. A light transmission tube (32) is vertically arranged at the center of the light transmission turbidimeter (3). A long strip light source (33) is vertically arranged inside the light transmission tube (32). Four sets of fan-shaped baffles (34) are arranged on the outer periphery of the light transmission tube (32) of the light transmission turbidimeter (3). The long strip light transmission station (31) is formed between adjacent baffles (34). A long strip light source (33) is vertically opened on the periphery of the light transmission tube (32). The light-transmitting hole (35) is connected to the light-transmitting station (31). The light transmittance turbidimeter (3) is provided with a photosensitive reaction plate (36) at the end of the light-transmitting station (31) away from the light-transmitting tube (32) to receive light passing through the blood collection tube (6) and detect the light transmittance. The adjacent blocks (34) are vertically provided with a positioning slot (341) with a horizontal cross section in the shape of an arc at one end and the side near the light-transmitting tube (32). The side end of the blood collection tube (6) is inserted into the positioning slot (341).

2. The combined coagulation and platelet function testing and analysis device as described in claim 1, characterized in that: It also includes a sealing cover (12) located outside the centrifuge (2), the transmittance turbidimeter (3), the waste liquid collection assembly (7) and the aggregation inducer addition assembly (8). A constant temperature base (1) is provided at the bottom of the sealing cover (12). The constant temperature base (1) has a built-in refrigeration device (11) that blows cold air into the sealing cover (12).

3. The combined coagulation and platelet function testing and analysis device as described in claim 1, characterized in that: The blood collection tube (6) includes an inner tube (61) and an outer tube (62). The inner tube (61) is vertically inserted into the outer tube (62). A drainage microtube (611) is vertically arranged at the lower end of the inner tube (61). Large fins (621) are horizontally arranged on both sides of the top of the outer tube (62). A groove (622) is horizontally opened on the upper surface of the large fins (621) on the side close to the outer tube (62). Small fins (612) are horizontally arranged on both sides of the top of the inner tube (61) and embedded in the groove (622). Large magnetic metal points (623) and small magnetic metal points (613) are embedded in the top of the large fins (621) and small fins (612). A cap (63) is detachably inserted into the top of the inner tube (61). A top magnetic metal point (631) is embedded in the top of the cap (63).

4. The combined coagulation and platelet function testing and analysis device as described in claim 3, characterized in that: The waste liquid collection assembly (7) includes a waste liquid collection rack (71) for vertical insertion and fixation of the inner sleeve (61), a drain rack (72) vertically sliding above the waste liquid collection rack (71), four drain push rods (73) vertically arranged on the drain rack (72) that move synchronously with the drain rack (72) and are inserted into the inner sleeve (61), and a receiving beaker (74) arranged below the waste liquid collection rack (71).

5. The combined coagulation and platelet function testing and analysis device as described in claim 3, characterized in that: The clamping assembly (9) includes a clamping shaft (91) that is vertically rotatably connected to the top of the vertical frame (4), a first adsorption head (92) that is vertically slidably disposed on the side end of the clamping shaft (91) to magnetically adsorb the cover (63), a second adsorption head (93) that is horizontally slidably connected and vertically slidably disposed on the side end of the clamping shaft (91), and a third adsorption head (94). The second adsorption head (93) magnetically adsorbs the small magnetic metal point (613), and the third adsorption head (94) magnetically adsorbs the large magnetic metal point (623).

6. The combined coagulation and platelet function testing and analysis device as described in claim 3, characterized in that: The placement suspension (5) has four insertion holes (51) vertically arranged in a circumferentially evenly spaced manner. The upper end surface of the placement suspension (5) has fixed grooves (52) on both sides of the insertion holes (51) for the large burr (621) to be inserted. The lower end of the placement suspension (5) is provided with a support frame (53) on both sides of the insertion holes (51) to support the lower end of the blood collection tube (6).

7. The combined coagulation and platelet function testing and analysis device as described in claim 1, characterized in that: The aggregation inducer addition assembly (8) includes an addition frame (81) that is horizontally connected to the side of the vertical frame (4) and bent vertically upward at the other end, an addition support plate (82) that is horizontally set on the top of the addition frame (81), a plurality of addition needles (83) that are vertically inserted into the addition support plate (82) and have aggregation inducer drawn inside, and a pusher plate (84) that is vertically slidably set on the upper side of the addition support plate (82) and pushes the addition needles (83) downward to squeeze out the aggregation inducer.

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