一种基于凝血分析仪用试剂的双对数定标方法
By establishing a standard baseline in the coagulation analyzer and performing real-time anti-interference correction, the problems of environmental factors affecting calibration accuracy and optical response stability are solved, achieving higher measurement accuracy and reliability.
CN121558633BActive Publication Date: 2026-07-17ALI BIOTECHNOLOGY TAIZHOU CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ALI BIOTECHNOLOGY TAIZHOU CO LTD
- Filing Date
- 2025-12-16
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing calibration methods for coagulation analyzers are inadequate in terms of environmental interference and optical response stability, leading to issues with measurement accuracy and reliability.
Method used
By recording baseline values for temperature and turbidity, a standard baseline is established. Data is monitored in real time and fractional normalization is performed to resist interference. The coefficients of the double logarithmic calibration equation are dynamically adjusted to generate a corrected detection signal curve, thereby compensating for environmental factors.
Benefits of technology
This improves the accuracy and reliability of measurements, ensuring calibration precision and stability under long-term operation and different batches of reagents.
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Abstract
本发明公开了一种基于凝血分析仪用试剂的双对数定标方法，涉及体外诊断技术领域，包括，基于温度和浊度的偏差，通过检测信号校正函数，对检测信号进行分式归一化抗干扰校正，获取校正后的检测信号并生成校正后的检测信号曲线；结合校正后的检测信号与初始双对数定标方程，生成预测浓度并与参考浓度进行比较，获取浓度偏差，根据校正后的检测信号曲线中的凝固时间，生成抗干扰校正响应量；基于抗干扰校正响应量，计算测试样本的双对数残差，将双对数残差与浓度偏差关联，依据残差方向对检测信号校正函数中的系数进行实时步长调整，生成更新后的双对数定标方程。本发明提高了双对数定标方程的准确性和鲁棒性。
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