一种亚铁血红素结合位点预测方法、系统、介质和设备

By extracting multiple features of the protein and using hierarchical networks and multi-head attention mechanisms for analysis, the problem of insufficient prediction accuracy of heme binding sites in existing technologies has been solved, achieving higher prediction accuracy and generalization ability.

CN121565244BActive Publication Date: 2026-07-17YANGTZE DELTA REGION INST (QUZHOU) UNIV OF ELECTRONIC SCI & TECH OF CHINA

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
YANGTZE DELTA REGION INST (QUZHOU) UNIV OF ELECTRONIC SCI & TECH OF CHINA
Filing Date
2025-11-24
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing methods for predicting heme binding sites neglect the overall description of protein structure, resulting in poor prediction accuracy, especially for predicting specific functional sites of proteins.

Method used

By acquiring protein sequence and structural information, multiple physicochemical properties, amino acid embedding features, and protein secondary structure features are extracted. Hierarchical networks and multi-head attention mechanisms are used for feature fusion and analysis, including bidirectional long short-term memory neural networks and fully connected neural networks, to capture the contextual and local dependencies of protein sequences.

Benefits of technology

It significantly improves the prediction accuracy of heme binding sites and enhances the understanding and prediction capabilities of protein sequence features, especially in the accuracy and generalization ability of identifying heme binding sites.

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Abstract

本发明公开了一种亚铁血红素结合位点预测方法、系统、介质及设备,涉及位点预测领域,包括获取蛋白质序列及结构信息;根据蛋白质序列及结构信息,提取多个理化属性特征、氨基酸嵌入特征和蛋白质二级结构特征;对多个理化属性特征进行融合操作,确定全局进化特征,对全局进化特征进行时序特征分析并融合,确定时序特征,通过对时序特征进行非线性组合和映射,以获取未知蛋白质为亚铁血红素结合蛋白质的概率;对未知蛋白质为亚铁血红素结合蛋白质的概率、氨基酸嵌入特征和蛋白质二级结构特征进行拼接,得到拼接后的特征,对拼接后的特征的不同部分进行加权求和,获取亚铁血红素结合位点预测结果。
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