一种单细胞信号通路重建方法、系统、设备及介质

By constructing a single-cell signaling pathway reconstruction method based on the intersection of highly expressed genes and highly variable genes and a graph Transformer model, a consensus signaling network is generated, which solves the problem that existing technologies cannot completely reconstruct the entire process of intercellular communication. This achieves a fully interpretable pathway for intercellular communication, thereby improving the depth and interpretability of the research.

CN121565265BActive Publication Date: 2026-07-17ACADEMY OF MILITARY MEDICAL SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ACADEMY OF MILITARY MEDICAL SCIENCES
Filing Date
2025-11-28
Publication Date
2026-07-17

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Abstract

本申请涉及一种单细胞信号道路重建方法、系统、设备及介质。所述方法包括：基于每个细胞的高表达基因与高变基因的交集，从全局信号参考网络中提取子网络，生成细胞特异性信号网络；将所述细胞特异性信号网络输入图Transformer模型，生成共识信号网络；将对应源细胞的所述共识信号网络定义为源细胞共识网络，将对应所述目标细胞的所述共识信号网络定义为目标细胞共识网络；基于配体‑受体知识库，搜索所述源细胞共识网络中的配体及所述目标细胞共识网络中的受体之间的路径，生成跨细胞信号通路列表。采用本方法能够准确捕捉细胞间的通讯机制，有效提升对细胞间信号的系统性理解。
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