基于FK3的碳硼烷偶联肽及其制备方法和应用
By introducing lysine residues with carborane-coupled side chains into the FK3 sequence, carborane-coupled peptides were synthesized, which solved the problems of insufficient antibacterial activity and stability of FK3, and achieved effective treatment of drug-resistant strains and biofilm infections, with higher therapeutic index and safety.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- LANZHOU UNIV
- Filing Date
- 2025-11-28
- Publication Date
- 2026-07-17
AI Technical Summary
Existing natural antimicrobial peptide FK3 has problems with moderate antimicrobial activity and poor stability, making it difficult to effectively treat drug-resistant bacteria and biofilm infections.
A series of carborane-coupled peptides were designed and synthesized. By introducing lysine residues with carborane-coupled side chains into the FK3 sequence, coupled peptides with improved amino acid sequences, including CB14-B to CB20-B, were prepared using the Fmoc solid-phase synthesis method, thereby enhancing their antibacterial activity and stability.
It enhances antibacterial activity against drug-resistant strains such as Escherichia coli and Acinetobacter baumannii, improves serum stability and anti-biofilm activity, reduces hemolytic activity, and has better in vivo safety and therapeutic index compared with traditional antibiotics.
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Figure CN121574193B_ABST
Abstract
Citation Information
Patent Citations
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CN119798460A