亚油酸诱导口腔黏膜上皮向干唇上皮表型转化的应用及方法
By inducing oral mucosal epithelial cells to transform into dry lip epithelial cells using linoleic acid, the problems of donor damage and insufficient barrier function in dry lip repair were solved, achieving efficient enhancement of the barrier function of mucosal tissue and reduction of complications.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
- Filing Date
- 2025-12-05
- Publication Date
- 2026-07-17
AI Technical Summary
Existing dry lip repair techniques have limitations. Traditional surgical methods can damage the donor site and the survival rate of grafts is uncertain. Insufficient barrier function after mucosal tissue transplantation can lead to complications such as dryness and peeling. Existing technologies cannot solve these problems at their root.
By using an appropriate concentration of linoleic acid to induce the transformation of oral mucosal epithelial cells into dry lip epithelial cells, the cell differentiation program was regulated, resulting in downregulation of oral mucosal epithelial cell-specific markers and upregulation of skin epidermal cell-specific markers, thus achieving the transformation of mucosal epithelium into dry lip epithelium.
It significantly enhances the mucosal tissue barrier function, reduces post-transplant complications such as dryness and peeling, provides a fundamental solution, improves the repair effect of dry lips, and reduces the frequency of treatment.
Smart Images
Figure CN121574906B_ABST