ISORSM isomer as well as preparation method and application thereof
CN121609654APending Publication Date: 2026-03-06QIDONG DONGYUE PHARM CO LTD
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Patent Information
- Application Number
- CN202511836465.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-08
- Publication Date
- 2026-03-06
AI Technical Summary
Technical Problem
In the existing technology, the preparation methods of ISORSM isomer impurities are complex and not simple enough, which affects the quality control and medication safety of ellamod active pharmaceutical ingredient.
Method used
The ISONSM isomer was prepared by Chan-Lam coupling reaction, catalytic hydrogenation, methanesulfonation and Houben-Hoesch reaction steps, including the synthesis of intermediates ISONO2, ISONH2 and ISOMS, and finally the ISONSM isomer was obtained.
Benefits of technology
A simple and efficient method for preparing ISONSM isomers is provided, which improves the quality testing and medication safety of ellamod active pharmaceutical ingredient and ensures product quality control.
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Figure CN121609654A_ABST
Abstract
The invention provides an ISORSM isomer as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. According to the invention, ISORSM isomer impurities in Iguratimod starting materials are prepared, and the ISORSM isomer impurities have a structure as shown in a formula IV; the efficient preparation, separation and identification of the impurity are of great significance to the quality detection of the subsequent iguratimod raw material medicine and the preparation of the iguratimod raw material medicine. The preparation method provided by the invention is simple and feasible, and the purity of the obtained impurity reference substance is high. According to the method, convenience is provided for impurity analysis and research of the iguratimod raw material medicine and the preparation thereof, and a detection method and a judgment basis are provided for production and medication safety of iguratimod. And formula IV.
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