一种柔性水凝胶神经电极及其制备方法与应用

By combining PA66 fiber film with PVA hydrogel to form a flexible substrate and encapsulation layer, and using micro-nano fabrication technology, the biocompatibility, mechanical matching and process compatibility issues of existing neural electrodes have been solved, achieving high stability and high resolution neural signal acquisition.

CN121647685BActive Publication Date: 2026-07-17SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
Filing Date
2026-02-05
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing flexible neural electrode materials have shortcomings in terms of biocompatibility, mechanical compatibility, and process compatibility, which can easily lead to inflammatory reactions, tissue damage, and signal failure during long-term implantation.

Method used

A flexible substrate and encapsulation layer formed by combining PA66 fiber film and PVA hydrogel were used, along with micro-nano fabrication technologies such as electrospinning and photolithography, to fabricate a high-density metal electrode array, achieving mechanical matching and anti-swelling properties between the electrodes and brain tissue.

Benefits of technology

It improves the long-term stability of electrodes and brain tissue, reduces tissue damage and inflammatory response, supports continuous acquisition of high-resolution neural signals, and meets the needs of neurological disease diagnosis and treatment and brain-computer interface.

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Abstract

本发明公开了一种柔性水凝胶神经电极及其制备方法与应用。所述柔性水凝胶神经电极包括依次层叠设置的柔性基底层、电极层及封装层,所述柔性基底层、封装层均是由纤维薄膜与水凝胶复合形成的水凝胶纤维复合薄膜结构,且所述纤维薄膜嵌于水凝胶内部;所述纤维薄膜为聚己内酰胺纤维薄膜,所述水凝胶为聚乙烯醇水凝胶;所述电极层包含复数个金属电极,每个金属电极均设有电极点和焊盘;所述封装层设置有复数个开孔结构,所述开孔与电极点、焊盘对应设置并使电极点、焊盘暴露。本发明提供的柔性水凝胶神经电极具有良好生物相容性、抗溶胀性及工艺兼容性;同时该柔性水凝胶神经电极可稳定应用于植入式脑机接口,用于实现神经信号的长期稳定采集与传输。
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