一种高效抗弧菌肽及其应用
By designing highly efficient anti-Vibrio peptides with specific amino acid sequences, the problems of antibiotic resistance and insufficient activity of natural antimicrobial peptides have been solved, achieving highly efficient inhibition and killing of Vibrio, which is suitable for aquaculture, clinical medicine and water disinfection.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- BINZHOU MEDICAL COLLEGE
- Filing Date
- 2026-02-09
- Publication Date
- 2026-07-17
AI Technical Summary
Existing antibiotics have problems with drug resistance in controlling Vibrio strains and pollute the environment. Natural antimicrobial peptides have insufficient activity and poor stability, making it difficult to meet the actual needs of aquaculture and clinical medicine.
The highly efficient anti-Vibrio peptide was designed and synthesized. The specific amino acid sequence consists of 18-20 amino acids, with a net charge of +6, a Boman index of 1.32-2.13, and a hydrophobicity of 39%-60%. The peptide exhibits a specific secondary structure, as predicted by Alphafold 2 structure and verified by circular dichroism spectroscopy. It is intended for use in the preparation of anti-Vibrio infection products.
It effectively inhibits and kills Vibrio, has good stability and low cytotoxicity, and is widely used in aquaculture, clinical medicine and water disinfection, providing prevention and control solutions in multiple fields.
Smart Images
Figure CN121673373B_ABST