Seed treatment microcapsule suspension-flowable

Abstract

The application discloses a seed treatment microcapsule suspension-suspension agent, and active ingredients of the seed treatment microcapsule suspension-suspension agent are mefenoxam, prothioconazole and fludioxonil, wherein the mefenoxam exists in the form of mefenoxam microcapsule suspension agent, and the prothioconazole and the fludioxonil exist in the form of prothioconazole-fludioxonil suspension agent. In the seed treatment microcapsule suspension-suspension agent, the mefenoxam microcapsule slow release forms long-acting protection of root systems, and is particularly effective for corn soil-borne diseases; meanwhile, the prothioconazole and the fludioxonil have rapid effects, and simultaneously prevent and control seed-borne diseases and seedling stage pests, and the three are complementary in the compounding mechanism and have remarkable prevention and treatment effects. The seed treatment microcapsule suspension-suspension agent has both quick-acting and long-acting properties, has good film-forming adhesion, greatly reduces the dosage compared with conventional dosage forms, does not lose the active ingredients, and can promote seedling growth, improve seedling survival rate, is low in toxicity and environmental protection, and provides an efficient and innovative scheme for green prevention and control of corn seedling diseases.

Description

Technical Field

[0001] This application belongs to the field of pesticide mixture technology, specifically relating to a seed treatment microcapsule suspension. Background Technology

[0002] White spot disease of maize has become a new and major disease of maize, and its core pathogen is *Plasmodium styracifolium*. (Epicoccum latusicollum Unlike the pathogens of traditional soil-borne diseases of maize (such as maize bacterial wilt caused by a mixture of pathogens such as Fusarium and Pythium), *Plasmodium styracifolium* has extremely strong host specificity and infection targeting. Specifically, it attacks only the middle and lower functional leaves of maize. Its spores can germinate and penetrate the leaf cuticle within 24 hours under high humidity conditions, and can rapidly multiply in the palisade and spongy tissues of the leaves, forming a unique "latent infection - rapid symptom onset" pathogenic model.

[0003] The above reasons make the prevention and control of broad-necked cocci particularly difficult: (1) The bacteria have strong survival ability and can overwinter in soil diseased plant debris for more than 3 years. It can also spread far through seeds, forming a complete transmission chain of "soil incubation - seed-borne bacteria - field wind and rain spread - cyclic infection". Once a disease center appears in the field, it can spread to the whole field within 7-10 days; (2) The symptoms are highly concealed. After infection, there is a 1-2 week incubation period. In the early stage, it only shows light green spots the size of pinheads, which are easily confused with physiological nutrient deficiency symptoms such as nitrogen and magnesium deficiency in corn. When the lesions expand into round / elliptical white spots with a diameter of 3-5 mm and yellow halo appears at the edge, the photosynthetic function of the plant has been irreversibly damaged, eventually leading to leaf drying and grain filling obstruction. The yield loss in severely affected plots can reach more than 30%, which is much higher than the average loss rate of traditional diseases such as corn stem rot.

[0004] Therefore, there is an urgent need to develop and research specialized agents that are highly targeted and can precisely act on the lesions to fill the technological gap in specialized control agents and suitable formulations for this disease. Summary of the Invention

[0005] In view of this, the primary objective of this application is to provide a method for preventing and controlling Acinetobacter thunbergii. (Epicoccus) broad-necked This seed treatment microcapsule suspension-suspension formulation for maize white spot disease caused by *Pseudomonas aeruginosa* contains metalaxyl, prothioconazole, and fludioxonil as active ingredients. Metalaxyl exists as a metalaxyl microcapsule suspension, while prothioconazole and fludioxonil exist as a prothioconazole·fludioxonil suspension. This seed treatment microcapsule suspension-suspension formulation achieves targeted control of maize white spot disease, delays the development of fungal resistance, and provides a comprehensive effect suitable for the maize growth cycle. (Epicoccum latusicollum This provides a dedicated seed treatment solution for the efficient control of white spot disease in corn caused by _____.

[0006] To achieve the above objectives, this application adopts the following technical solution: One aspect of this application discloses a seed treatment microcapsule suspension-suspension agent containing active ingredients, the active ingredients being metalaxyl, prothioconazole, and fludioxonil; wherein metalaxyl exists in the form of metalaxyl microcapsule suspension, and prothioconazole and fludioxonil exist in the form of prothioconazole·fludioxonil suspension.

[0007] Another aspect of this application discloses a method for preparing the seed treatment microcapsule suspension-suspending agent described in this application, comprising the following steps: Preparation of microcapsule suspension of cypermethrin; Preparation of prothioconazole·fludioxonil suspension; The seed treatment microcapsule suspension was prepared by mixing the metalaxyl-methyl microcapsule suspension, prothioconazole-fludioxonil suspension, and a suspending agent.

[0008] Another aspect of this application discloses the application of seed treatment microcapsule suspensions as described in this application, or seed treatment microcapsule suspensions prepared by the method, in the prevention and control of soil-borne diseases in maize.

[0009] The beneficial effects of this application are: The core active ingredients of the seed treatment microcapsule suspension-suspension agent in this application are metalaxyl, prothioconazole, and fludioxonil. Metalaxyl exists in the form of metalaxyl microcapsule suspension, while prothioconazole and fludioxonil exist in the form of prothioconazole·fludioxonil suspension. Through the controlled-release characteristics of the metalaxyl microcapsules, the effective ingredients are slowly released into the soil, continuously resisting early infection by *Agrococcus brasiliensis* during seed germination. Simultaneously, the suspension properties of prothioconazole and fludioxonil ensure that the effective ingredients can be rapidly translocated to the seedling leaves after seed germination, precisely killing the already invading fungal mycelium and blocking its reproduction and spread. Furthermore, the composite formulation of the microcapsule suspension-suspension agent has high seed encapsulation and strong adhesion, preventing the effective ingredients from being lost with rainwater or adsorbed by the soil, significantly improving utilization. Ultimately, it achieves the comprehensive effect of "targeted control of maize white spot disease, delaying fungal resistance, and adapting to the maize growth cycle," providing a dedicated seed treatment solution for the efficient control of maize white spot disease. Detailed Implementation

[0010] The embodiments of this application will be clearly and completely described below. The technical solutions in the embodiments described below are exemplary and only possible technical implementations of this application, not all possible implementations. Those skilled in the art can combine the embodiments of this application to obtain other embodiments without creative effort, and these embodiments are also within the protection scope of this application.

[0011] The first aspect of this application discloses a seed treatment microcapsule suspension-suspension agent containing active ingredients, said active ingredients being metalaxyl, prothioconazole, and fludioxonil, wherein metalaxyl exists in the form of metalaxyl microcapsule suspension, and prothioconazole and fludioxonil exist in the form of prothioconazole·fludioxonil suspension.

[0012] Mefenoxam, a phenylamide fungicide, has the chemical name N-(2,6-dimethylyl)-N-(methoxyacetyl)-D-alanine methyl ester and the molecular formula C2,6-xylyl. 15 H 21 NO4, with a molecular weight of 279.33 and CAS number 70630-17-0, has the following structure: .

[0013] Prothioconazole, a triazole fungicide, has the chemical name 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione and the molecular formula C2. 14 H 15 Cl2N3OS, with a molecular weight of 344.26 and CAS number 178928-70-6, has the following structure: .

[0014] Fludioxonil, belonging to the benzylpyrrole class of fungicides, has the chemical name 4-(2,2-difluoro-1,3-benzodioxane-4-yl)-1H-pyrrole-3-onitrile and the molecular formula C2. 12 H6F2N2O2, with a molecular weight of 248.2 and CAS number 131341-86-1, has the following structure: .

[0015] In this application, the above three agents were combined to prepare a seed treatment microcapsule suspension-suspension formulation, which was found to have good control and pest-prevention effects on crop diseases and pests, especially against Acanthopanax gracilistylus (…). Epicoccum latus White spot disease in corn caused by )

[0016] These three components have synergistic advantages. Specifically: metalaxyl inhibits pathogen cell wall synthesis and blocks spore germination; prothioconazole targets and inhibits the mitochondrial respiratory chain, killing mycelia that invade the leaf mesophyll; and fludioxonil inhibits the synthesis of cell division-related proteins, preventing pathogen reproduction. The combination of these three components forms a full-cycle control mechanism of "germination inhibition—mycelial killing—reproduction blocking," reducing the risk of drug resistance. Simultaneously, a specific seed treatment microcapsule suspension-suspension agent is prepared. Metalaxyl, in microcapsule form, can be slowly released to resist pathogens in the soil and prevent early infection; prothioconazole and fludioxonil, existing in suspension, can be rapidly translocated to seedling leaves to combat seedling infection, with their complementary advantages. This seed treatment microcapsule suspension-suspension agent can fill the gap left by *Plasmodium styracifolium* (…). Epicoccum latus This fills the technological gap in specific control agents and suitable formulations for white spot disease in corn.

[0017] It should be understood that the content and ratio of the three active ingredients in the seed treatment microcapsule suspension are not particularly limited and can be confirmed experimentally, a capability possessed by those skilled in the art. In some specific examples of this application, the mass ratio of metalaxyl, prothioconazole, and fludioxonil among the active ingredients is (4-12):(5-13):(1-5). Within this ratio range, the three ingredients synergistically enhance each other, resulting in a significant control effect. Specific mass ratios can be any of the following: 4:13:1, 6:11:2, 8:9:3, 10:7:4, 12:5:5, or any range between any two ratios. Within the above ratio range, further superior control effects can be obtained by adjusting and optimizing the ratio of the active ingredients. Therefore, in some preferred examples of this application, the mass ratio of metalaxyl, prothioconazole, and fludioxonil is 8:9:3. At this ratio, the synergistic effect of the three ingredients is most significant, thus achieving the best control effect.

[0018] It is also understood that, in this application, the proportion of the active ingredient in the seed treatment microcapsule suspension can be determined experimentally. As an example, the active ingredient accounts for 0.2%-40% of the total mass of the seed treatment microcapsule suspension, for example, any value or a range between 0.2%, 0.5%, 1%, 2%, 3%, 4%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, and 40%.

[0019] In this application, the seed treatment microcapsule suspension further includes at least one pesticide-acceptable excipient. The excipient includes, but is not limited to, at least one of the following: emulsifiers, oily monomers, aqueous monomers, organic solvents, dispersants, antifreeze agents, anti-caking agents, suspending agents, thickeners, wetting agents, defoamers, film-forming agents, fungicides, pH adjusters, colorants, and media. In actual formulation, those skilled in the art can select one or more excipients from the above categories for compounding according to formulation requirements and agronomic requirements.

[0020] It is understandable that the specific types of excipients can be selected according to the actual situation, without any special restrictions.

[0021] In some specific examples, the emulsifier may be, for example, at least one of calcium dodecylbenzenesulfonate, sodium dodecylbenzenesulfonate, styrene-maleic anhydride copolymer, fatty alcohol polyoxyethylene ether, sorbitan monostearate polyoxyethylene ether, sodium lauryl sulfate, polyvinyl alcohol, polycarboxylate and naphthalene sulfonate, but is not limited thereto.

[0022] In some specific examples, the organic solvent may be at least one of N,N-dimethylformamide, cyclohexanone, xylene, and aromatic solvents (such as Solvesso 150), but is not limited thereto.

[0023] In some specific examples, the oily monomer may be at least one of polyisocyanates such as terephthalic diisocyanate (PPDI), dimethyl biphenyl diisocyanate, dodecane diisocyanate, and dichloroformate, but is not limited thereto.

[0024] In some specific examples, the aqueous monomer may be, for example, water.

[0025] In some specific examples, the dispersant may be at least one of phosphate esters, lignin sulfonates, benzene sulfonates, alkylphenol polyoxyethylene ether methyl ether condensate sulfates, alkyl sulfonate calcium salts, naphthalene sulfonate formaldehyde condensate sodium salts, alkylphenol polyoxyethylene ethers, fatty acid polyoxyethylene esters, fatty amine polyoxyethylene ethers, and glycerol fatty acid ester polyoxyethylene ethers, but is not limited thereto.

[0026] In some specific examples, the antifreeze may be at least one of propylene glycol, glycerol, polyethylene glycol, sorbitol, and urea, but is not limited thereto.

[0027] In some specific examples, the thickener may be, for example, at least one of xanthan gum, magnesium aluminum silicate, and sodium carboxymethyl cellulose, but is not limited thereto.

[0028] In some specific examples, the anti-caking agent may be, for example, at least one of tricalcium phosphate and silicon dioxide, but is not limited thereto.

[0029] In some specific examples, the antifungal agent may be at least one of benzisothiazolinone, sodium benzoate, sorbic acid, and propylparaben, but is not limited thereto.

[0030] In some specific examples, the pH adjuster may be, for example, at least one of sodium hydroxide, ammonia, hydrochloric acid, citric acid, and phosphoric acid, but is not limited thereto.

[0031] In some specific examples, the suspending agent may be at least one of magnesium aluminum silicate, bentonite, kaolin, and diatomaceous earth, but is not limited thereto.

[0032] In some specific examples, the wetting agent may be, for example, at least one of sodium dodecylbenzene sulfonate, sodium secondary alkyl sulfonate, isomeric alcohol polyoxyethylene ether, and castor oil polyoxyethylene ether, but is not limited thereto.

[0033] In some specific examples, the defoamer may be at least one of silicone emulsion defoamers and high-carbon alcohol polyoxyethylene ether defoamers, but is not limited thereto.

[0034] In some specific examples, the film-forming agent may be at least one of polyvinyl alcohol, vinyl polyester, and modified starch, but is not limited thereto.

[0035] In some specific examples, the colorant may be, for example, at least one of Acid Red and Indigo, but is not limited thereto.

[0036] For seed treatment microcapsule suspensions, the medium is usually water, and the balance is made up to 100% based on the active ingredients and excipients.

[0037] In some specific examples of this application, the content of each raw material component in the seed treatment microcapsule suspension-suspension agent, by mass percentage, is as follows: metalaxyl 0.1%-15%, prothioconazole 0.05%-15%, fludioxonil 0.05%-10%, emulsifier 0-2%, organic solvent 0-2%, oily monomer 0.01-5%, water-based monomer 0.01-25%, dispersant 0-3%, antifreeze 0-3%, anti-caking agent 0-1%, suspending agent 0-1%, wetting agent 0-3%, defoamer 0-1%, thickener 0-1%, film-forming agent 0-1%, mildew inhibitor 0-1%, pH adjuster 0-0.05%, colorant 0-0.05%, and the balance is water.

[0038] The second aspect of this application discloses a method for preparing seed treatment microcapsule suspension-suspension agent as described in this application, which uses metalaxyl to construct the microcapsule phase and prothioconazole and fludioxonil to construct the suspension phase, and achieves the composite form of "microcapsule + suspension" through a stepwise preparation process.

[0039] In some specific examples, its preparation includes the following steps: Preparation of microcapsule suspension of cypermethrin; Preparation of prothioconazole·fludioxonil suspension; The seed treatment microcapsule suspension was prepared by mixing the metalaxyl-methyl microcapsule suspension, prothioconazole-fludioxonil suspension, and a suspending agent.

[0040] The preparation of the Jingjiashuangling microcapsule suspension includes the following steps: The nail polish extract, organic solvent and emulsifier are thoroughly mixed to form a nail polish extract emulsion, and the oily monomer is dispersed in the nail polish extract emulsion to form the first material; The first material, the aqueous monomer, and water are mixed evenly to obtain the second material. Adjust the pH of the second material to 4-7, stir and react at 200-300 rpm for 2-3 hours at 50-60℃, and obtain the third material through solidification and polycondensation reaction; The third material is mixed with a dispersant, a thickener and an antifreeze to obtain a metalaxyl-maniol microcapsule suspension, wherein the average particle size Dv50 of the microcapsules is controlled in the range of 3-10 μm.

[0041] Furthermore, the preparation of the prothioconazole·fludioxonil suspension includes the following steps: Premixing: The technical grade of prothioconazole and fludioxonil are mixed with dispersant, wetting agent, part of defoamer and deionized water, and pre-dispersed by high-speed shearing machine to form a uniform slurry; Wet grinding: The pre-dispersed slurry is transferred into a sand mill, grinding media are added, and wet grinding is carried out until the particle size of the material reaches D90≤5μm to obtain the core grinding fluid; Preparation: Add antifreeze, thickener and remaining defoamer to the core grinding fluid in sequence, and stir continuously until it is evenly mixed; pH adjustment and post-treatment: The pH of the mixed system was adjusted to 6-7.5 using a pH adjuster, and deionized water was added to the specified mass. After homogenization and filtration, the prothioconazole·fludioxonil suspension was obtained.

[0042] In this application, the step of preparing seed-treated microcapsule suspension includes: Metalaxyl-M microcapsule suspension and prothioconazole·fludioxonil suspension were mixed and stirred evenly to obtain a premixed slurry. The slurry was fully emulsified and dispersed under closed and pressurized conditions to make it uniform and fine. The fined slurry was mixed and ground with a suspending agent and discharged. After being filtered through a 200-325 mesh sieve and packaged, a flowable suspension was obtained, which is the seed treatment microcapsule suspension-suspension agent.

[0043] This seed treatment microcapsule suspension-suspension agent was used for corn seed coating treatment, thereby achieving a complementary effect between the controlled release of metalaxyl and the rapid translocation of prothioconazole and fludioxonil: After coating, the metalaxyl microcapsules slowly release the active ingredients as the seeds germinate, continuously resisting the early infection of seeds and seedling roots by *Agrococcus brasiliensis* in the soil; while prothioconazole and fludioxonil are rapidly translocated to the seedling leaves through seed absorption, precisely inhibiting or killing the initially infected *Agrococcus brasiliensis* on the leaves, forming a full-stage protection of "seed-root-leaf", significantly improving the full-cycle control effect against corn white spot disease.

[0044] The present application will be further illustrated below with reference to specific embodiments. It should be noted that the specific embodiments below are for illustrative purposes only and do not limit the scope of the present application in any way.

[0045] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the specification of this application is for the purpose of describing particular embodiments only and is not intended to be limiting of this application.

[0046] In addition, unless otherwise specified, methods without detailed conditions or steps are conventional methods, and the reagents and materials used are commercially available.

[0047] Indoor bioactivity experiments 1. Experimental subject: *Streptococcus latum* ( Epicoccum latus ).

[0048] 2. Raw material: Metallic acid granules, 95%, PD20094902.

[0049] Prothioconazole technical grade, 97%, PD20190004.

[0050] Fludioxonil technical grade, 99%, PD20181224.

[0051] 3. Experimental steps: Metalaxyl, prothioconazole, and fludioxonil technical grade pesticides were each prepared into 10000 mg / L stock solutions using acetone. Based on preliminary experiments, solutions of each single agent and mixture were added to PDA medium cooled to 45°C to prepare five series of drug-containing culture plates. The specific drug dosages for the drug-containing plates are shown in Table 1. Table 1. Drug composition of drug-containing tablets

[0052] Referring to the guidelines for indoor bioassay of pesticides NY / T 1156.2-2006, the plate method was used to plate pure cultures of *Pseudomonas aeruginosa* (…). Epicoccum latus Under aseptic conditions, using a sterile punch with a diameter of 5 mm, cut a mycelial cake from the edge of the colony. Inoculate the mycelial cake onto the center of a drug-containing plate using an inoculator, with the mycelial side facing down. Incubate in a constant temperature incubator at 25±1℃.

[0053] 4. Investigation Method: The diameter of the colonies was measured using a digital vernier caliper. The diameter of each colony was measured vertically once using the cross-sectional method, and the average value was taken.

[0054] 5. Survey time and frequency: When the diameter of the blank control colonies is about 5cm, measure the colony diameter once.

[0055] 6. Calculation method: Based on the survey results, the colony growth diameter for each treatment was calculated using formula (1): (1) In formula (1), D is the diameter of the colony growth; D1 is the diameter of the colony; and D2 is the diameter of the mycelial cake.

[0056] Based on the colony growth diameter, the inhibition rate of each treatment against the pathogen was calculated according to formula (2), in percentage (%), and the result was rounded to two decimal places: (2) In formula (2), I—mycelial growth inhibition rate; D0—colony growth diameter of blank control; D t —The diameter of colony growth after chemical treatment.

[0057] 7. Statistical Analysis: Based on the logarithmic values ​​of drug concentrations and the probability values ​​of corresponding pathogen growth inhibition rates, regression analysis was performed using the DPS data processing system to calculate the EC50 value and its 95% confidence limit for each drug.

[0058] The measured toxicity index (ATI) of the mixture was calculated according to formula (3) using Sun Yunpei's method, the theoretical toxicity index of the mixture was calculated according to formula (4), and finally the co-toxicity coefficient (CTC value) of the mixture was calculated according to formula (5): (3) In formula (3), ATI is the measured toxicity index of the mixture; S is the EC50 of the standard fungicide, with the unit of milligrams per liter (mg / L); M is the EC50 of the mixture, with the unit of milligrams per liter (mg / L).

[0059] (4) In formula (4), TTI is the theoretical toxicity index of the mixture; TI A —is the toxicity index of fungicide A; P A —is the percentage content of fungicide A in the mixture, with the unit of percentage (%);TI B —is the toxicity index of fungicide B; P B —is the percentage content of fungicide B in the mixture, with the unit of percentage (%);TI C —is the toxicity index of fungicide C; P C —is the percentage content of fungicide C in the mixture, with the unit of percentage (%).

[0060] (5) In formula (5), CTC is the co-toxicity coefficient; ATI is the measured toxicity index of the mixture; TTI is the theoretical toxicity index of the mixture.

[0061] When the co-toxicity coefficient CTC of the compound mixture ≥ 120, it shows a synergistic effect; when CTC ≤ 80, it shows an antagonistic effect; when 80 < CTC < 120, it shows an additive effect, and the results are shown in Table 2.

[0062] Table 2 Indoor combined toxicity test results of metalaxyl-M, prothioconazole and fludioxonil against Epulorhynchus sp.

[0063] From the indoor combined toxicity test results of metalaxyl-M, prothioconazole and fludioxonil against Epulorhynchus sp. in Table 2, it can be seen that for the 5 groups of ternary compound agents of metalaxyl-M (A), prothioconazole (B) and fludioxonil (C) tested, their co-toxicity coefficients are all significantly greater than 120, indicating that the three active ingredients have a significant synergistic effect in the application of controlling Epulorhynchus sp., rather than a simple additive effect. From the perspective of toxicity indicators, there are obvious differences in the EC 50 of each single agent against Epulorhynchus sp. Among them, fludioxonil (C) has the highest activity, with an EC 50 of 1.7586 mg / L; prothioconazole (B) ranks second, with an EC 50 of 3.1789 mg / L; metalaxyl-M (A) is relatively lower, with an EC 50 of 7.5112 mg / L. After compounding, the EC 50All were lower than any single agent, demonstrating a significant enhancement in the virulence of the compound formulation against the pathogen. Further analysis of the synergistic effect of the compound combination revealed the most pronounced synergistic effect when the ratio of the three active ingredients was A:B:C = 8:9:3 (corresponding to combination F), with a co-toxicity coefficient as high as 328.10, far exceeding other compound combinations; simultaneously, the EC at this ratio... 50 The lowest value, only 1.0881 mg / L, indicates the strongest toxicity against *Plasmodium styridis*, demonstrating the optimal synergistic effect of the formulation. The co-toxicity coefficients of the other four formulations ranged from 222.68 to 267.24, EC50. 50 All concentrations, ranging from 1.3530 to 1.5573 mg / L, exhibited stable and significant synergistic effects.

[0064] Seed treatment microcapsule suspension - Suspension preparation examples Example 1: 18% Metalaxyl·Prothioconazole·Fluordioxonil Seed Treatment Microcapsule Suspension-Suspension Formulation In this embodiment, the raw material composition of the seed treatment microcapsule suspension-suspension agent is as follows: The ingredients are: 4g of metalaxyl-M, 13g of prothioconazole, 1g of fludioxonil, 1.5g of organic solvent (N,N-dimethylformamide), 1.0g of emulsifier (calcium dodecylbenzenesulfonate), 0.20g of thickener (xanthan gum), 2.7g of dispersant (sodium lignosulfonate), 2g of oily monomer (terephthalic acid diisocyanate), 22g of watery monomer (water), 2.9g of antifreeze (sorbitol), 1.8g of wetting agent (sodium secondary alkyl sulfonate), 0.5g of defoamer (organosilicon emulsion type defoamer), 0.6g of suspending agent (magnesium aluminum silicate), 3.4g of anticaking agent (tricalcium phosphate), 2.5g of film-forming agent (polyvinyl alcohol), 2.2g of mildew inhibitor (sodium benzoate), 1.3g of colorant (Acid Red), and citric acid as pH adjuster. The final volume is made up to 100g with deionized water.

[0065] The preparation method of the seed treatment microcapsule suspension is as follows: Preparation of microcapsule suspension of cypermethrin; Preparation of prothioconazole·fludioxonil suspension; The seed treatment microcapsule suspension was prepared by mixing the metalaxyl-methyl microcapsule suspension, prothioconazole-fludioxonil suspension, and a suspending agent.

[0066] The preparation of the Jingjiashuangling microcapsule suspension includes the following steps: The nail polish extract, organic solvent and emulsifier are thoroughly mixed to form a nail polish extract emulsion, and the oily monomer is dispersed in the nail polish extract emulsion to form the first material; The first material, the aqueous monomer, and water are mixed evenly to obtain the second material. Adjust the pH of the second material to 4-7, stir and react at 200-300 rpm for 2-3 hours at 50-60℃, and obtain the third material through solidification and polycondensation reaction; The third material is mixed with a dispersant, a thickener and an antifreeze to obtain a metalaxyl-maniol microcapsule suspension, wherein the average particle size Dv50 of the microcapsules is controlled in the range of 3-10 μm.

[0067] Furthermore, the preparation of the prothioconazole·fludioxonil suspension includes the following steps: Premixing: Accurately measured amounts of prothioconazole and fludioxonil technical materials are mixed with dispersant, wetting agent, part of defoamer and deionized water, and pre-dispersed by a high-speed shearing machine to form a uniform slurry.

[0068] Wet grinding: The pre-dispersed slurry is transferred into a sand mill, grinding media are added, and wet grinding is carried out until the particle size of the material reaches D90≤5μm to obtain the core grinding fluid.

[0069] Preparation: Add antifreeze, thickener and remaining defoamer to the core grinding fluid in sequence, and stir continuously until they are evenly mixed.

[0070] pH adjustment and post-treatment: The pH of the mixed system was adjusted to 6-7.5 using a pH adjuster, and deionized water was added to the specified mass. After homogenization and filtration, the prothioconazole·fludioxonil suspension was obtained.

[0071] In this application, the step of preparing seed-treated microcapsule suspension includes: Metalaxyl-M microcapsule suspension and prothioconazole·fludioxonil suspension were mixed and stirred evenly to obtain a premixed slurry. The slurry was fully emulsified and dispersed under closed and pressurized conditions to make it uniform and fine. The fined slurry was mixed and ground with a suspending agent and discharged. After being filtered through a 200-325 mesh sieve and packaged, a flowable suspension was obtained, which is the seed treatment microcapsule suspension-suspension agent.

[0072] Example 2: 19% Metalaxyl-Methionate·Prothioconazole·Fluordioxonil Seed Treatment Microcapsule Suspension In this embodiment, the composition of the seed treatment microcapsule suspension-suspension agent is as follows: The ingredients are: 6g of metalaxyl-M, 11g of prothioconazole, 2g of fludioxonil, 1.8g of organic solvent (N,N-dimethylformamide), 1.2g of emulsifier (calcium dodecylbenzenesulfonate), 0.25g of thickener (xanthan gum), 3.5g of dispersant (sodium lignosulfonate), 2.9g of oily monomer (terephthalic acid diisocyanate), 23g of watery monomer (water), 3.5g of antifreeze (sorbitol), 2.2g of wetting agent (isomeric alcohol polyoxyethylene ether), 0.6g of defoamer (higher alcohol polyoxyethylene ether defoamer), 0.8g of suspending agent (bentonite), 2.6g of anticaking agent (tricalcium phosphate), 2.9g of film-forming agent (polyvinyl alcohol), 1.4g of mildew inhibitor (sodium benzoate), 1.5g of colorant (Acid Red), and citric acid as pH adjuster. The final volume is made up to 100g with deionized water.

[0073] The preparation method of the seed treatment microcapsule suspension is the same as in Example 1.

[0074] Example 3: 10% Metalaxyl-Methionate·Prothioconazole·Fluordioxonil Seed Treatment Microcapsule Suspension-Suspension Formulation In this embodiment, the composition of the seed treatment microcapsule suspension-suspension agent is as follows: Metalaxyl-M 4g, Prothioconazole 4.5g, Fludioxonil 1.5g, Organic solvent (N,N-dimethylformamide) 1.0g, Organic solvent (N,N-dimethylformamide) 1.0g, Emulsifier (Calcium dodecylbenzenesulfonate) 0.8g, Thickener (Xanthan gum) 0.15g, Dispersant (Sodium lignosulfonate) 1.6g, Oily monomer (terephthalic acid diisocyanate) 1.7g, Watery monomer (water) 23g. Suspension agent (magnesium aluminum silicate) 0.3g, wetting agent (sodium dodecylbenzene sulfonate) 1.0g, defoamer (organosilicone emulsion type defoamer) 0.3g, antifreeze agent (sorbitol) 2.2g, anticaking agent (tricalcium phosphate) 1.4g, film-forming agent (polyvinyl alcohol) 2.0g, mildew inhibitor (sodium benzoate) 1.1g, colorant (acid red) 1.2g, pH adjuster is citric acid, and deionized water is added to make up to 100g.

[0075] The preparation method of the seed treatment microcapsule suspension is the same as in Example 1.

[0076] Example 4: 21% Metalaxyl-Methionate·Prothioconazole·Fluordioxonil Seed Treatment Microcapsule Suspension-Suspension Formulation In this embodiment, the composition of the seed treatment microcapsule suspension-suspension agent is as follows: The ingredients are: 10g of metalaxyl-M, 7g of prothioconazole, 4g of fludioxonil, 2.0g of organic solvent (N,N-dimethylformamide), 1.5g of emulsifier (calcium dodecylbenzenesulfonate), 0.30g of thickener (xanthan gum), 2.4g of dispersant (sodium lignosulfonate), 3.4g of oily monomer (terephthalic acid diisocyanate), 23g of watery monomer (water), 3.9g of antifreeze (sorbitol), 0.5g of suspending agent (bentonite), 2.5g of wetting agent (castor oil polyoxyethylene ether), 0.7g of defoamer (high carbon alcohol polyoxyethylene ether defoamer), 4.1g of anticaking agent (tricalcium phosphate), 4.0g of film-forming agent (polyvinyl alcohol), 3.8g of mildew inhibitor (sodium benzoate), 2.1g of colorant (Acid Red), and citric acid as pH adjuster. The final volume is made up to 100g with deionized water.

[0077] The preparation method of the seed treatment microcapsule suspension is the same as in Example 1.

[0078] Example 5: 22% Metalaxyl-Methionate·Prothioconazole·Fluordioxonil Seed Treatment Microcapsule Suspension-Suspension Formulation In this embodiment, the composition of the seed treatment microcapsule suspension-suspension agent is as follows: The ingredients are: 12g of metalaxyl-M, 5g of prothioconazole, 5g of fludioxonil, 2.2g of organic solvent (N,N-dimethylformamide), 1.8g of emulsifier (calcium dodecylbenzenesulfonate), 0.35g of thickener (xanthan gum), 2.7g of dispersant (sodium lignosulfonate), 3.9g of oily monomer (terephthalic acid diisocyanate), 23g of watery monomer (water), 4.1g of antifreeze (sorbitol), 4.2g of anticaking agent (tricalcium phosphate), 2.8g of wetting agent (sodium secondary alkyl sulfonate), 0.8g of defoamer (organosilicon emulsion type defoamer), 0.6g of suspending agent (magnesium aluminum silicate), 4.1g of film-forming agent (polyvinyl alcohol), 4.2g of mildew inhibitor (sodium benzoate), 2.2g of colorant (Acid Red), and citric acid as pH adjuster. The final volume is made up to 100g with deionized water.

[0079] The preparation method of the seed treatment microcapsule suspension is the same as in Example 1. Comparative Example 1: 10% Metalaxyl Seed Treatment Microcapsule Suspension The ingredients are: 10g of metalaxyl-methyl sulfonate, 2.4g of dispersant (sodium lignosulfonate), 3.4g of oily monomer (terephthalic acid diisocyanate), 13g of watery monomer (water), 3.9g of antifreeze (sorbitol), 2.5g of organic solvent (N,N-dimethylformamide), 1.8g of emulsifier (calcium dodecylbenzenesulfonate), 0.5g of thickener (xanthan gum), 4.1g of anticaking agent (tricalcium phosphate), 4.0g of film-forming agent (polyvinyl alcohol), 3.8g of antifungal agent (sodium benzoate), 0.5g of suspending agent (magnesium aluminum silicate), 1.5g of wetting agent (isomeric alcohol polyoxyethylene ether), 0.4g of defoamer (organosilicone emulsion type defoamer), 2.1g of colorant (acid red), and citric acid as pH adjuster. The total amount is made up to 100g with deionized water.

[0080] The preparation method of the seed treatment microcapsule suspension is the same as in Example 1.

[0081] Comparative Example 2: 10% Prothioconazole Seed Treatment Suspension The ingredients are: 10g of prothioconazole, 2.4g of dispersant (sodium lignosulfonate), 3.9g of antifreeze (sorbitol), 1.2g of wetting agent (sodium dodecylbenzenesulfonate), 0.5g of defoamer (high carbon alcohol polyoxyethylene ether defoamer), 4.1g of anticaking agent (tricalcium phosphate), 4.0g of film-forming agent (polyvinyl alcohol), 3.8g of mildew inhibitor (sodium benzoate), 0.5g of thickener (xanthan gum), 0.7g of suspending agent (bentonite), 2.1g of colorant (Acid Red), and citric acid as pH adjuster. The total amount is made up to 100g with deionized water.

[0082] The preparation method of the seed treatment suspension is the same as in Example 1.

[0083] Comparative Example 3: 10% Fludioxonil Seed Treatment Suspension Fludioxonil 10g, dispersant (sodium lignosulfonate) 2.4g, antifreeze (sorbitol) 3.9g, wetting agent (castor oil polyoxyethylene ether) 1.3g, defoamer (organosilicone emulsion type defoamer) 0.4g, anticaking agent (tricalcium phosphate) 4.1g, film-forming agent (polyvinyl alcohol) 4.0g, mildew inhibitor (sodium benzoate) 3.8g, thickener (xanthan gum) 0.5g, colorant (acid red) 2.1g, suspending agent (bentonite) 0.6g, pH adjuster is citric acid, and deionized water is added to make up to 100g.

[0084] The preparation method of the seed treatment suspension is the same as in Example 1.

[0085] Comparative Example 4: 12% Metalaxyl-M·Fluordioxonil Seed Treatment Microcapsule Suspension-Suspension Formulation In this embodiment, metalaxyl exists in the form of metalaxyl microcapsule suspension, and fludioxonil exists in the form of fludioxonil suspension. The composition of the seed treatment microcapsule suspension is as follows: The ingredients are: 6g of metalaxyl-M, 6g of fludioxonil, 2.0g of organic solvent (N,N-dimethylformamide), 1.6g of wetting agent (sodium alkyl sulfonate), 0.5g of defoamer (high carbon alcohol polyoxyethylene ether defoamer), 1.5g of emulsifier (calcium dodecylbenzene sulfonate), 15g of water-based monomer (water), 0.30g of thickener (xanthan gum), 1.6g of dispersant (sodium lignosulfonate), 0.5g of suspending agent (magnesium aluminum silicate), 1.7g of oil-based monomer (terephthalic acid diisocyanate), 2.2g of antifreeze agent (sorbitol), 1.4g of anticaking agent (tricalcium phosphate), 2.0g of film-forming agent (polyvinyl alcohol), 1.1g of mildew inhibitor (sodium benzoate), 1.2g of colorant (Acid Red), and citric acid as pH adjuster. The final volume is made up to 100g with deionized water.

[0086] The preparation method of the seed treatment microcapsule suspension is the same as in Example 1.

[0087] Comparative Example 5: 12% Prothioconazole·Fluordioxonil Seed Treatment Suspension The composition of the seed treatment suspension in this embodiment is as follows: 6g of prothioconazole, 6g of fludioxonil, 2.0g of organic solvent (N,N-dimethylformamide), 1.4g of wetting agent (sodium dodecylbenzenesulfonate), 0.4g of defoamer (high carbon alcohol polyoxyethylene ether defoamer), 1.5g of emulsifier (calcium dodecylbenzenesulfonate), 0.30g of thickener (xanthan gum), 0.6g of suspending agent (bentonite), 1.6g of dispersant (sodium lignosulfonate), 2.2g of antifreeze agent (sorbitol), 1.4g of anticaking agent (tricalcium phosphate), 2.0g of film-forming agent (polyvinyl alcohol), 1.1g of mildew inhibitor (sodium benzoate), 1.2g of colorant (Acid Red), and citric acid as pH adjuster, with deionized water to make up to 100g.

[0088] The preparation method of the seed treatment suspension is the same as in Example 1.

[0089] Comparative Example 6: 12% Metalaxyl·Prothioconazole Seed Treatment Microcapsule Suspension-Suspension Formulation In this embodiment, metalaxyl exists in the form of metalaxyl microcapsule suspension, and prothioconazole exists in the form of prothioconazole suspension. The composition of the seed treatment microcapsule suspension is as follows: The ingredients are: 6g of metalaxyl-M, 6g of prothioconazole, 2.0g of organic solvent (N,N-dimethylformamide), 1.5g of emulsifier (calcium dodecylbenzenesulfonate), 15g of water-based monomer (water), 1.7g of wetting agent (isomeric alcohol polyoxyethylene ether), 0.5g of defoamer (organosilicone emulsion type defoamer), 0.30g of thickener (xanthan gum), 1.6g of dispersant (sodium lignosulfonate), 1.7g of oil-based monomer (terephthalic acid diisocyanate), 2.2g of antifreeze (sorbitol), 0.8g of suspending agent (magnesium aluminum silicate), 1.4g of anticaking agent (tricalcium phosphate), 2.0g of film-forming agent (polyvinyl alcohol), 1.1g of mildew inhibitor (sodium benzoate), 1.2g of colorant (Acid Red), and citric acid as pH adjuster. The final volume is made up to 100g with deionized water.

[0090] The preparation method of the seed treatment microcapsule suspension is the same as in Example 1.

[0091] Physicochemical property determination According to the NY / T1860-2016 Guidelines for the Determination of Physicochemical Properties of Pesticides, the seed treatment microcapsule suspensions prepared in Examples 1-5 were tested for suspension rate, thermal storage stability (54℃), cold storage stability (5℃), release rate, coating uniformity, and freeze-thaw stability to verify the formulation stability. The results are shown in Table 3.

[0092] Table 3 Results of Physicochemical Property Measurements

[0093] The physicochemical property test results shown in Table 3 indicate that all performance indicators of the seed treatment microcapsule suspension prepared in this application meet the relevant standards for pesticide formulations. The suspension rate of all examples is ≥95%, and the coating uniformity rate is ≥90%, ensuring that the active ingredients can be uniformly attached to the seed surface to form a dense protective film, avoiding the loss of active ingredients due to soil erosion and rainwater leaching after sowing. After 20 minutes, the proportion of metalaxyl-mancozeb outside the capsule reaches more than 90%, which can quickly dissolve the active ingredients during the critical period of seed water absorption and germination. It works synergistically with the suspended components of prothioconazole and fludioxonil to form a high-concentration protective ring around the seed, accurately resisting the infection of pathogens in the soil during the germination period. At the same time, the microcapsule structure can reduce the rapid degradation of active ingredients in the soil and prolong the local protection time.

[0094] Regarding stability, the heat storage (54°C), cold storage (5°C), and freeze-thaw stability of Examples 1-5 all met the requirements, indicating that the formulation can adapt to different storage environments and climatic conditions in different regions and has good shelf-life stability. Among them, the metalaxyl-M is... Prothioconazole Example 3, with a fludioxonil mass ratio of 8:9:3, exhibited the best microcapsule dissolution characteristics (93%) and outstanding overall physicochemical properties.

[0095] Field efficacy trials 1. Test location: Liangzhuang East Village Test Base, Liangzhuang Town, Daiyue District, Tai'an City, Shandong Province.

[0096] 2. Selection of crops and cultivars: Denghai 605.

[0097] 3. Test subject: *Streptococcus latum* ( Epicoccum latus ).

[0098] 4. Seeds were coated on June 18th at an indoor temperature of 26.1℃ and a relative humidity of 51.8%. Sowing took place on June 19th. The weather at sowing was cloudy with a northerly wind of 0.8 m / s, a temperature of 35.5℃, and a relative humidity of 29.9%.

[0099] 5. Test reagents: The formulations in Examples 1-5 and Comparative Examples 1-6 were all prepared by Anhui Fengle Agricultural Chemical Co., Ltd.

[0100] 6. Area and duplication: (1) Area: 20m 2 (2) Number of repetitions: 4 times.

[0101] 7. Application Method: Before sowing corn, calculate the seed quantity for each plot based on the sowing rate per acre and the experimental design. Coat the seeds according to the treatment. Weigh the dosage of the preparation for each treatment based on 500 grams of seeds. Add an appropriate amount of water at a ratio of slurry to seeds of 1:50 and stir the preparation evenly to make a slurry. Pour the seeds into the coating machine and slowly add the prepared slurry for each treatment. Once the slurry is evenly distributed on the seed surface, pour it into an enamel tray to dry.

[0102] 8. Survey time and number of times On July 5th of the same year, a survey was conducted on the disease condition of corn seedlings; on October 8th of the same year, a survey was conducted on the disease condition of corn at the waxy maturity stage.

[0103] The prevention and control effect is calculated according to the following formula: ; ; ; .

[0104] The dosage and control effect of each agent are shown in Table 4.

[0105] Table 4. Effects of different agents on *Plasmodium styracifolium* ( ) Epicoccum latus ) Drug efficacy test results

[0106] Each experimental treatment had an effect on *Streptococcus davidii* (maize). Epicoccum latusThe control effects of the five ternary compound formulations are shown in Table 4. Under the condition of a formulation dosage of 80 ml / 100 kg of seeds, the average disease index of the five formulations ranged from 0.29 to 5.71, with corresponding control effects of 80.44% to 99.01%. Among them, Example 3 (10% metalaxyl-propiconazole-thiophanate-methyl seed treatment microcapsule suspension-suspension) showed the best control effect, with an average disease index of only 0.29 and a control effect as high as 99.01%, which was significantly better than the other ternary compound formulations. The control effects of Examples 4 and 5 were 90.32% and 88.23%, respectively, showing good control performance and effectively inhibiting the infection of Acanthopanax gracilistylus. The control effects of Examples 1 and 2 were 80.44% and 86.42%, respectively, also achieving a good control level and meeting the needs of maize seed disease control.

[0107] Six control agents (single-agent and binary compound formulations) showed significantly lower control efficacy than the ternary compound formulation under the condition of 100 ml / 100 kg seed dosage. Even with a 25% increase in dosage, the control efficacy of the ternary compound formulation was still not achieved. Specifically, Comparative Examples 1-3 (single-agent controls) showed control efficacy of only 10.26%-33.30%, with an average disease index of 19.57-26.29, indicating weak inhibitory effects against *Agrococcus latum*. Comparative Examples 4-6 (binary compound controls) showed control efficacy of 47.30%-64.84%, with an average disease index of 10.29-15.43. While these showed some improvement over the single-agent controls, they still lagged significantly behind the ternary compound formulation, highlighting the synergistic effect of the ternary compound formulation. The blank control (water treatment) had an average disease index of 29.43, showing no natural disease prevention effect, further validating the necessity of the tested agents for controlling *Agrococcus latum*.

[0108] The control efficacy of single-agent comparative formulations was ranked as follows: Comparative Formulation 3 > Comparative Formulation 2 > Comparative Formulation 1. Fludioxonil alone showed the best efficacy, but it was still far lower than that of the ternary compound formulation. Among them, Comparative Formulation 1 was a seed-treated microcapsule suspension. The coating adhesion and slow dissolution characteristics of the microcapsule formulation can reduce the rapid degradation of the active ingredient. However, the single active ingredient can only act on a certain growth stage of the pathogen and cannot cover the complex transmission chain of Acanthopanax gracilistylus: "soil latent - seed-borne - field spread - cyclic infection". Comparative Formulations 2 and 3 were seed-treated suspensions. The coating adhesion was weak, and the active ingredient was easily migrated with soil moisture or adsorbed by soil particles. They also had the problem of a single mechanism of action, which further limited the control efficacy. This shows that no single agent, regardless of the formulation, can meet the complex control requirements of this disease.

[0109] Comparative Example 4 (Seed Treatment Microcapsule Suspension-Suspension Agent, Metalaxyl-M) The binary combination of metalaxyl and fludioxonil exhibits the best control efficacy among binary combinations. The germination inhibition effect of metalaxyl and the reproduction blocking effect of fludioxonil form a partial synergy, covering two key growth stages of the pathogen. Simultaneously, the microcapsule suspension-suspension formulation for seed treatment further enhances the control effect—metalaxyl microcapsules dissolve rapidly during germination, synergistically forming a localized high-concentration protection with the suspended components of fludioxonil. The complex structure of the formulation improves the retention rate of the active ingredient on the seed surface, reduces environmental degradation, and allows the synergistic effect of the binary combination to be fully realized. However, this combination lacks the killing effect of prothioconazole on mycelium that has already invaded the leaf mesophyll, and cannot block the core link of the pathogen's "infection-proliferation" cycle, resulting in a lower control efficacy than ternary compound formulations.

[0110] Comparative Example 6 (Seed Treatment Microcapsule Suspension-Suspension Agent, Metalaxyl-M) The efficacy of the binary compound formulation of prothioconazole also benefits from the advantages of seed treatment microcapsule suspension-suspension formulations: metalaxyl microcapsules protect seeds, rapidly dissolve during germination to protect roots, and prothioconazole suspension coating protects seedlings, providing rapid leaf protection and controlling early infection. However, due to the lack of fludioxonil's blocking effect on the pathogen's reproductive stage, the pathogen can still cause secondary infection through spore diffusion. Furthermore, the binary compound's mechanism of action has a limited coverage, so its efficacy is lower than that of Comparative Formulation 4, and even lower than that of the ternary compound formulation.

[0111] Comparative Example 5 (Seed Treatment Suspension, Prothioconazole) The efficacy of the binary combination of fludioxonil was the lowest among binary combinations. In terms of formulation, it uses a common seed treatment suspension, resulting in poor coating adhesion and easy loss of active ingredients. It cannot form a stable, high-concentration local protection during the critical period of seed germination, and its utilization rate is far lower than that of seed treatment microcapsule suspension-suspension formulations. In terms of active ingredients, both prothioconazole and fludioxonil focus on killing and inhibiting the reproduction of foliar pathogens, lacking the targeted control of latent spores in the soil by metalaxyl. This makes the roots susceptible to infection in the early stages of seed germination, creating a source of disease. The combined effect of these two factors makes its efficacy significantly lower than that of comparative examples 4 and 6, which used seed treatment microcapsule suspension-suspension formulations.

[0112] All treatments showed good corn emergence rates, with no emergence inhibition issues caused by pesticide treatments. The emergence rates of the ternary compound examples ranged from 90.50% to 95.25%, with Example 3 showing the highest emergence rate (95.25%), balancing excellent control efficacy with good safety. The emergence rates of the single-agent controls (Comparative Examples 1-3) ranged from 90.25% to 91.50%, and the emergence rates of the binary compound controls (Comparative Examples 4-6) ranged from 90.25% to 90.75%, both close to the emergence rates of the ternary compound examples. The emergence rate of the blank control was 96.00%. All pesticide treatments had no significant negative impact on corn emergence, indicating that the tested formulations were safe to use.

[0113] It should be noted that this application is not limited to the above-described embodiments. The above embodiments are merely examples, and any embodiments with the same structure and effect as the technical concept within the scope of this application are included in the technical scope of this application. Furthermore, various modifications that can be conceived by those skilled in the art to the embodiments, and other ways of constructing by combining some of the constituent elements of the embodiments, without departing from the spirit of this application, are also included in the scope of this application.

Claims

1. Used for the prevention and treatment of Acanthopanax senticosus. Epicoccum latusicollum Seed treatment microcapsule suspension-suspension agent for corn white spot disease, characterized in that, The seed treatment microcapsule suspension contains active ingredients, namely metalaxyl, prothioconazole, and fludioxonil; wherein metalaxyl exists in the form of metalaxyl microcapsule suspension, and prothioconazole and fludioxonil exist in the form of prothioconazole·fludioxonil suspension. The active ingredients, metalaxyl, prothioconazole and fludioxonil, are in any of the following mass ratios: 4:13:1, 6:11:2, 8:9:3, 10:7:4, 12:5:

5.

2. The seed treatment microcapsule suspension-suspension agent as described in claim 1, characterized in that, The active ingredients are metalaxyl, prothioconazole and fludioxonil in a mass ratio of 8:9:

3.

3. The seed treatment microcapsule suspension-suspension agent as described in claim 1, characterized in that, The active ingredient accounts for 0.2%-40% of the total mass of the seed treatment microcapsule suspension.

4. The seed treatment microcapsule suspension-suspension agent as described in claim 1, characterized in that, The raw material components of the seed treatment microcapsule suspension also include at least one pesticide-acceptable excipient.

5. The seed treatment microcapsule suspension-suspension agent as described in claim 4, characterized in that, The excipients include at least one of the following: emulsifier, organic solvent, oily monomer, water-based monomer, dispersant, antifreeze, wetting agent, defoamer, thickener, anticaking agent, suspending agent, film-forming agent, mildew inhibitor, pH adjuster, and colorant.

6. A method for preparing a seed treatment microcapsule suspension as described in any one of claims 1-5, characterized in that, Includes the following steps: Preparation of microcapsule suspension of cypermethrin; Preparation of prothioconazole·fludioxonil suspension; The seed treatment microcapsule suspension was prepared by mixing the metalaxyl-methyl microcapsule suspension, prothioconazole-fludioxonil suspension, and a suspending agent.

7. The method as described in claim 6, characterized in that, The preparation of the Jingjiashuangling microcapsule suspension includes the following steps: The nail polish extract, organic solvent and emulsifier are thoroughly mixed to form a nail polish extract emulsion, and the oily monomer is dispersed in the nail polish extract emulsion to form the first material; The first material, the aqueous monomer, and water are mixed evenly to obtain the second material. Adjust the pH of the second material to 4-7, stir and react at 200-300 rpm for 2-3 hours at 50-60℃, and obtain the third material through solidification and polycondensation reaction; The third material is mixed with a dispersant, a thickener and an antifreeze to obtain a metalaxyl-maniol microcapsule suspension, wherein the average particle size Dv50 of the microcapsules is 3-10 μm; And / or, the preparation of the prothioconazole·fludioxonil suspension includes the following steps: Premixing: Prothioconazole, fludioxonil, dispersant, wetting agent, defoamer and deionized water are mixed and pre-dispersed by a high-speed shearing machine to form a uniform slurry; Wet grinding: The pre-dispersed slurry is wet ground until the particle size reaches D90≤5μm to obtain the core grinding fluid; Preparation: Add antifreeze, thickener and remaining defoamer to the core grinding fluid in sequence, and stir continuously until it is evenly mixed; pH adjustment and post-treatment: The pH of the mixed system was adjusted to 6-7.5 using a pH adjuster, and deionized water was added to the specified mass. After homogenization and filtration, the prothioconazole·fludioxonil suspension was obtained. And / or, the steps for preparing seed-treated microcapsule suspensions include: Metalaxyl-M microcapsule suspension and prothioconazole-fludioxonil suspension were mixed and stirred evenly to obtain a premixed slurry. The slurry was fully emulsified and dispersed under closed and pressurized conditions to make the premixed slurry uniform and fine. The fined slurry was mixed with a suspending agent, ground and discharged. After sieving and packaging, a flowable suspension was obtained to obtain the seed treatment microcapsule suspension-suspension agent.

8. The application of the seed treatment microcapsule suspension-suspension prepared according to any one of claims 1-5 or the method described in any one of claims 6-7 in the control of soil-borne diseases of maize, wherein the disease is *Plasmodium styracifolium*. Epicoccum latusicollum This causes white spot disease in corn.

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