Interleukin-1 receptor antagonist protein

Abstract

The present disclosure relates to a tissue fluid extraction control method, device, equipment and storage medium, the equipment comprises: a control device, a temperature sensor, a heat conduction component, an electrochemical sensor, the temperature sensor comprises a heating unit, the electrochemical sensor comprises an extraction electrode, one end of the temperature sensor is connected with the control device, the other end of the temperature sensor is connected with the heat conduction component, and the heat conduction component is also connected with the extraction electrode, and the control device is used for controlling the temperature sensor to perform self-heating through the heating unit, so that the heat generated by self-heating is transmitted to the extraction electrode through the heat conduction component.

Description

Technical Field

[0001] This disclosure relates to blood glucose monitoring technology, and more specifically, to a method, apparatus, device, and storage medium for controlling tissue fluid extraction. Background Technology

[0002] Continuous glucose monitoring (CGM) devices are a key technology that indirectly reflects blood glucose levels by detecting the glucose concentration in tissue fluid.

[0003] When monitoring blood glucose using continuous glucose monitoring devices, tissue fluid is actively extracted by extraction electrodes attached to the user's skin for glucose concentration detection. However, this detection technology has a problem: the efficiency of the extraction electrodes in extracting tissue fluid is temperature-dependent. Specifically, at room temperature (approximately 25°C), the extraction speed is slow, resulting in a significant lag in the detection signal and making it difficult to capture rapid fluctuations in postprandial blood glucose in real time. In low-temperature environments (such as winter), the viscosity of the tissue fluid increases, further drastically reducing the extraction speed. This not only exacerbates the signal lag but also forces a prolonged contact time between the electrode and the skin to obtain an effective signal, greatly increasing the risk of discomfort such as redness, swelling, and stinging, resulting in a poor user experience.

[0004] Therefore, there is a need to provide a technical solution that can stably and efficiently extract tissue fluid at different temperatures. Summary of the Invention

[0005] One objective of this invention is to provide a new technical solution for a continuous blood glucose monitoring device.

[0006] According to a first aspect of the present invention, a continuous glucose monitoring device is provided, comprising: a control device, a temperature sensor, a heat-conducting component, and an electrochemical sensor, wherein the temperature sensor includes a heating unit, and the electrochemical sensor includes an extraction electrode. One end of the temperature sensor is connected to the control device, and the other end of the temperature sensor is connected to the heat-conducting component. The heat-conducting component is also connected to the extraction electrode. The control device is used to control the temperature sensor to self-heat through the heating unit, so that the heat generated by self-heating is transferred to the extraction electrode through the heat-conducting component.

[0007] Optionally, when the extraction electrode is attached to the user's skin surface, the temperature sensor is used to monitor the temperature of the user's skin surface.

[0008] Optionally, when the extraction electrode is attached to the user's skin surface, one side of the heat-conducting component is attached to the extraction electrode, and the other side is attached to the user's skin surface, and the contact area between the heat-conducting component and the user's skin surface is smaller than the contact area between the extraction electrode and the user's skin surface.

[0009] According to a second aspect of the present invention, a method for controlling tissue fluid extraction is provided, applied to a continuous glucose monitoring device as described in any of the first aspects, the method comprising: The temperature value collected by the temperature sensor and the preset temperature value are obtained, wherein the preset temperature value is the lower limit of the temperature range of the user's skin surface when the extraction electrode extracts the user's tissue fluid; If the temperature value collected by the temperature sensor is less than the preset temperature value, the difference between the temperature value collected by the temperature sensor and the preset temperature value is determined. The duty cycle of the PWM signal used to control the heating unit is determined based on the difference between the temperature value collected by the temperature sensor and the preset temperature value. The heating unit of the temperature sensor is controlled to heat up according to the duty cycle of the PWM signal.

[0010] Optionally, determining the duty cycle of the PWM signal used to control the heating unit based on the difference between the temperature value collected by the temperature sensor and the preset temperature value includes: If the difference between the temperature value collected by the temperature sensor and the preset temperature value is greater than the preset difference, the duty cycle of the PWM signal is determined to be the first duty cycle. If the difference between the temperature value collected by the temperature sensor and the preset temperature value is less than or equal to the preset difference, the duty cycle of the PWM signal is determined to be the second duty cycle, wherein the first duty cycle is greater than the second duty cycle.

[0011] Optionally, when the heating unit of the temperature sensor is controlled to heat based on a first duty cycle, the method further includes: The temperature values ​​collected by the temperature sensor are periodically acquired; If the difference between the temperature value collected by the temperature sensor and the preset temperature value is less than or equal to the preset difference, the duty cycle of the PWM signal is adjusted from the first duty cycle to the second duty cycle.

[0012] Optionally, the method further includes: When the temperature value collected by the temperature sensor is greater than or equal to the preset temperature value, the system controls the application of a loading voltage to the extraction electrode so that the extraction electrode can extract the user's tissue fluid based on the loading voltage.

[0013] According to a fourth aspect of the present invention, a tissue fluid extraction control device is provided, comprising: The acquisition module is used to acquire the difference between the temperature value collected by the temperature sensor and the preset temperature value, wherein the preset temperature value is the lower limit of the temperature range of the user's skin surface when the extraction electrode extracts the user's tissue fluid; The temperature difference determination module is used to determine the difference between the temperature value collected by the temperature sensor and the preset temperature value when the temperature value collected by the temperature sensor is less than the preset temperature value. The duty cycle determination module is used to determine the duty cycle of the PWM signal used to control the heating unit based on the difference between the temperature value collected by the temperature sensor and the preset temperature value. The heating control module is used to control the heating unit of the temperature sensor to heat up according to the duty cycle of the PWM signal.

[0014] According to a fourth aspect of the present invention, a tissue fluid extraction control device is provided, comprising a memory and a processor, the memory storing a computer program for controlling the processor to operate in order to perform the method according to any one of the second aspects.

[0015] According to a fifth aspect of the present invention, a computer-readable storage medium is provided having computer program instructions stored thereon, which, when executed by a processor, implement the method described in any one of the second aspects.

[0016] The continuous glucose monitoring device disclosed herein includes a control device, a temperature sensor, a heat-conducting component, and an electrochemical sensor. The temperature sensor includes a heating unit, and the electrochemical sensor includes an extraction electrode. One end of the temperature sensor is connected to the control device, and the other end is connected to the heat-conducting component, which is also connected to the extraction electrode. The control device controls the temperature sensor to self-heat through the heating unit, so that the heat generated by self-heating is transferred to the extraction electrode through the heat-conducting component. The inherent heating unit function of the temperature sensor is used as a controllable heat source, and an efficient thermal pathway is established through the heat-conducting component to provide a suitable working temperature microenvironment for the extraction of tissue fluid by the extraction electrode. This facilitates the extraction of tissue fluid by the extraction electrode, reduces the lag in glucose signal detection, and can accurately capture rapid fluctuations such as postprandial glucose. In addition, it shortens the overall contact time between the extraction electrode and the skin, avoiding the risk of skin irritation caused by prolonged contact and improper heating.

[0017] The features and advantages of the embodiments of this specification will become clear from the following detailed description of exemplary embodiments with reference to the accompanying drawings. Attached Figure Description

[0018] The accompanying drawings, which are incorporated in and form a part of this specification, illustrate embodiments of this specification and, together with their description, serve to explain the principles of these embodiments.

[0019] Figure 1 This is a schematic diagram of a continuous blood glucose monitoring device according to an embodiment of the present invention.

[0020] Figure 2 This is a schematic flowchart of a tissue fluid extraction control method according to an embodiment of the present invention.

[0021] Figure 3 This is a schematic flowchart of a tissue fluid extraction control method according to another embodiment of the present invention.

[0022] Figure 4 This is a schematic diagram of a tissue fluid extraction control device according to an embodiment of the present invention.

[0023] Figure 5 This is a schematic diagram of a tissue fluid extraction control device according to an embodiment of the present invention. Detailed Implementation

[0024] Various exemplary embodiments of this specification will now be described in detail with reference to the accompanying drawings.

[0025] The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the embodiments of this specification or their application or use.

[0026] It should be noted that similar labels and letters in the following figures indicate similar items; therefore, once an item is defined in one figure, it does not need to be discussed further in subsequent figures.

[0027] To address the aforementioned technical problems, this disclosure provides a continuous glucose monitoring device. The device includes a control unit, a temperature sensor, a heat-conducting component, and an electrochemical sensor. The temperature sensor includes a heating unit, and the electrochemical sensor includes an extraction electrode. One end of the temperature sensor is connected to the control unit, and the other end is connected to the heat-conducting component, which is also connected to the extraction electrode. The control unit controls the temperature sensor to self-heat via the heating unit, so that the heat generated by self-heating is transferred to the extraction electrode through the heat-conducting component. The inherent heating unit function of the temperature sensor is used as a controllable heat source, and an efficient thermal pathway is established through the heat-conducting component. This provides a suitable working temperature microenvironment for the extraction of tissue fluid by the extraction electrode, facilitating the extraction of tissue fluid and reducing glucose signal detection lag. In particular, it can accurately capture rapid fluctuations such as postprandial glucose. Furthermore, it shortens the overall contact time between the extraction electrode and the skin, avoiding the risk of skin irritation caused by prolonged contact and improper heating.

[0028] One embodiment of the present invention provides a continuous glucose monitoring device. According to... Figure 1 As shown, the continuous glucose monitoring device includes: a control unit, a temperature sensor, a heat-conducting component, and an electrochemical sensor. The temperature sensor includes a heating unit. The electrochemical sensor includes an extraction electrode.

[0029] One end of the temperature sensor is connected to the control device, and the other end of the temperature sensor is connected to the heat-conducting component, which is also connected to the extraction electrode.

[0030] The control device is used to control the temperature sensor to self-heat through the heating unit, so that the heat generated by self-heating is transferred to the extraction electrode through the heat-conducting component.

[0031] The control device can be a microprocessor (MCU), which is the computing and control unit of the continuous glucose monitoring device. It can acquire instructions, exchange information with external memory and logic components, and send instructions to the temperature sensor to trigger the temperature sensor's inherent "heating self-diagnosis" process, thereby activating the heat source when needed, especially when the ambient temperature is low or a decrease in the sampling rate is detected.

[0032] When the electrodes are attached to the user's skin, the temperature sensor monitors the skin's surface temperature. The temperature sensor in this embodiment integrates a heating unit. For example, the temperature sensor is an MTS4 series temperature sensor, which has an internal heating resistor with a heating power of 7.8mW and a heating self-diagnostic function.

[0033] The thermally conductive component is physically connected between the temperature sensor and the extraction electrode to establish an efficient, low-thermal-resistance thermal path, accurately and with low loss transferring the heat generated by the "heat self-diagnosis" function of the temperature sensor's heating unit to the extraction electrode interface performing the extraction function. The thermally conductive component can be a thermally conductive silicone sheet, metal foil, or thermally conductive gel.

[0034] With the extraction electrode attached to the user's skin, one side of the heat-conducting component is attached to the extraction electrode, and the other side is attached to the user's skin. The other side of the heat-conducting component faces the first side. The heat-conducting component can directly transfer some heat to the user's skin surface and also transfer some heat to the extraction electrode, which is beneficial for the extraction of the user's tissue fluid. The contact area between the heat-conducting component and the user's skin surface is smaller than the contact area between the extraction electrode and the user's skin surface. Because the contact area between the extraction electrode and the user's skin surface is larger, heat can be transferred to a larger area of ​​the extraction electrode, which is beneficial for the extraction of the user's tissue fluid.

[0035] An electrochemical sensor is used to detect the glucose concentration in tissue fluid. Specifically, glucose in the tissue fluid extracted by the extraction electrode can undergo an electrochemical reaction with the reactive enzyme in the electrochemical sensor. The glucose concentration in the tissue fluid is determined based on the current generated by the electrochemical reaction.

[0036] according to Figure 1 As shown, the continuous glucose monitoring device also includes an AFE (Active Front End) unit. The AFE unit is used to provide voltage for the electrochemical sensor to operate normally.

[0037] according to Figure 1 As shown, both the AFE unit and the electrochemical sensor have a three-electrode structure, namely a working electrode, a reference electrode, and an auxiliary electrode. The AFE unit and the electrochemical sensor are connected through the three-electrode structure.

[0038] One embodiment of the present invention provides a method for controlling tissue fluid extraction. This method is applied to a continuous glucose monitoring device.

[0039] according to Figure 2 As shown, the tissue fluid extraction control method of this embodiment includes the following steps S210 to S240.

[0040] Step S210: Obtain the temperature value collected by the temperature sensor and the preset temperature value, wherein the preset temperature value is the lower limit of the temperature range of the user's skin surface when the extraction electrode extracts the user's tissue fluid.

[0041] The temperature sensor collects the temperature value of the user's skin surface. When the electrodes are attached to the user's skin surface, the heat from the user's skin surface is transferred to the temperature sensor through the heat-conducting component, allowing the temperature sensor to determine the user's skin surface temperature.

[0042] When the extraction electrode extracts the user's tissue fluid, the user's skin surface temperature range is a pre-set temperature range suitable for the extraction electrode to extract the user's tissue fluid.

[0043] Step S220: If the temperature value collected by the temperature sensor is less than the preset temperature value, determine the difference between the temperature value collected by the temperature sensor and the preset temperature value.

[0044] If the temperature value collected by the temperature sensor is lower than the preset temperature value, it is determined that the current skin surface temperature of the user is not suitable for the extraction electrode to extract tissue fluid, and the extraction electrode needs to be heated.

[0045] The difference between the temperature value collected by the temperature sensor and the preset temperature value is determined based on the following calculation formula. ,

[0046] in, For the preset temperature value, The temperature value is collected by the temperature sensor.

[0047] Step S230: Determine the duty cycle of the PWM signal used to control the heating unit based on the difference between the temperature value collected by the temperature sensor and the preset temperature value.

[0048] A PWM (Pulse-Width Modulation) signal is a square wave signal with a fixed period, but the duration of the high-level signal within each period is adjustable. The duty cycle is the ratio of the pulse width to the entire period, expressed as a percentage.

[0049] In some embodiments, step S230 specifically includes: when the difference between the temperature value collected by the temperature sensor and the preset temperature value is greater than the preset difference, determining the duty cycle of the PWM signal as a first duty cycle; when the difference between the temperature value collected by the temperature sensor and the preset temperature value is less than or equal to the preset difference, determining the duty cycle of the PWM signal as a second duty cycle, wherein the first duty cycle is greater than the second duty cycle.

[0050] The preset difference can be set according to requirements, for example, 3℃.

[0051] Step S240: Control the heating unit of the temperature sensor to heat up according to the duty cycle of the PWM signal.

[0052] When the difference between the temperature value collected by the temperature sensor and the preset temperature value is greater than the preset difference, a higher first duty cycle (e.g., 70%) is used to trigger the heating self-diagnosis function of the heating unit, so that the heating unit is in the heating state for most of the time in a heating cycle. The heating speed is large, which can quickly increase the temperature of the extraction electrode. Compared with the case of no heating, the time for the extraction electrode to reach the appropriate working temperature is shortened, the efficiency of tissue fluid extraction is improved, and signal lag is reduced. In particular, it can more accurately capture rapid fluctuations such as postprandial blood glucose. In addition, the overall contact time between the extraction electrode and the skin is shortened, avoiding the risk of skin irritation caused by prolonged contact and improper heating.

[0053] If the difference between the temperature value collected by the temperature sensor and the preset temperature value is greater than the preset difference, a higher second duty cycle (e.g., 20%) is used to trigger the heating self-diagnosis function of the heating unit, so that the heating unit works in a short, intermittent pulse mode to prevent overshoot and keep the user's skin temperature stable within a narrow range (e.g., ±1°C) near the preset temperature value.

[0054] In some embodiments, when the heating unit of the temperature sensor is controlled to heat based on a first duty cycle, the method further includes: periodically acquiring the temperature value collected by the temperature sensor; and adjusting the duty cycle of the PWM signal from the first duty cycle to a second duty cycle when the difference between the temperature value collected by the temperature sensor and a preset temperature value is less than or equal to a preset difference. This prevents overshoot and keeps the user's skin temperature stable within a narrow range (e.g., ±1°C) near the preset temperature value.

[0055] In some embodiments, the method further includes: when the temperature value collected by the temperature sensor is greater than or equal to a preset temperature value, controlling the application of a loading voltage to the extraction electrode so that the extraction electrode extracts the user's tissue fluid based on the loading voltage.

[0056] If the temperature value collected by the temperature sensor is greater than or equal to the preset temperature value, it is determined that the current skin surface temperature of the user is suitable for the extraction electrode to extract tissue fluid. The extraction electrode is then directly supplied with a loading voltage so that the extraction electrode can extract the user's tissue fluid based on the loading voltage.

[0057] Combination Figure 3 The tissue fluid extraction control method provided by the present invention will be described below with a specific embodiment.

[0058] according to Figure 3 As shown, the tissue fluid extraction control method includes steps S301 to S308.

[0059] Step S301: Obtain the temperature value collected by the temperature sensor and the preset temperature value, wherein the preset temperature value is the lower limit of the user's skin surface temperature range when the extraction electrode extracts the user's tissue fluid.

[0060] Step S302: When the temperature value collected by the temperature sensor is greater than or equal to the preset temperature value, control the application of a loading voltage to the extraction electrode so that the extraction electrode can extract the user's tissue fluid based on the loading voltage.

[0061] After step S302 is executed, the following step S308 is executed.

[0062] Step S303: If the temperature value collected by the temperature sensor is less than the preset temperature value, determine the difference between the temperature value collected by the temperature sensor and the preset temperature value.

[0063] Step S304: If the difference between the temperature value collected by the temperature sensor and the preset temperature value is greater than the preset difference, the duty cycle of the PWM signal is determined to be the first duty cycle.

[0064] Step S305: Periodically acquire the temperature value collected by the temperature sensor; if the difference between the temperature value collected by the temperature sensor and the preset temperature value is less than or equal to the preset difference, adjust the duty cycle of the PWM signal from the first duty cycle to the second duty cycle.

[0065] Step S306: If the difference between the temperature value collected by the temperature sensor and the preset temperature value is less than or equal to the preset difference, the duty cycle of the PWM signal is determined to be the second duty cycle, wherein the first duty cycle is greater than the second duty cycle.

[0066] Step S307: Control the heating unit of the temperature sensor to heat up according to the duty cycle of the PWM signal.

[0067] Step S308: Glucose in the tissue fluid extracted by the extraction electrode undergoes an electrochemical reaction with the reactive enzyme in the electrochemical sensor. The glucose concentration in the tissue fluid is determined based on the current generated by the electrochemical reaction.

[0068] One embodiment of the present invention provides a tissue fluid extraction control device. According to... Figure 4 As shown, the tissue fluid extraction control device includes an acquisition module 410, a temperature difference determination module 420, a duty cycle determination module 430, and a heating control module 440.

[0069] The acquisition module 410 is used to acquire the difference between the temperature value collected by the temperature sensor and the preset temperature value, wherein the preset temperature value is the lower limit of the temperature range of the user's skin surface when the extraction electrode extracts the user's tissue fluid.

[0070] The temperature difference determination module 420 is used to determine the difference between the temperature value collected by the temperature sensor and the preset temperature value when the temperature value collected by the temperature sensor is less than the preset temperature value.

[0071] The duty cycle determination module 430 is used to determine the duty cycle of the PWM signal used to control the heating unit based on the difference between the temperature value collected by the temperature sensor and the preset temperature value.

[0072] The heating control module 440 is used to control the heating unit of the temperature sensor to heat up according to the duty cycle of the PWM signal.

[0073] In some embodiments, the duty cycle determination module 430 is used to determine the duty cycle of the PWM signal as a first duty cycle when the difference between the temperature value collected by the temperature sensor and the preset temperature value is greater than the preset difference; and to determine the duty cycle of the PWM signal as a second duty cycle when the difference between the temperature value collected by the temperature sensor and the preset temperature value is less than or equal to the preset difference, wherein the first duty cycle is greater than the second duty cycle.

[0074] In some embodiments, the device further includes a duty cycle adjustment module. The duty cycle adjustment module is used to periodically acquire the temperature value collected by the temperature sensor when the heating unit of the temperature sensor is controlled to heat based on a first duty cycle; and to adjust the duty cycle of the PWM signal from the first duty cycle to a second duty cycle when the difference between the temperature value collected by the temperature sensor and a preset temperature value is less than or equal to a preset difference.

[0075] In some embodiments, the device further includes a loading voltage control module, configured to control the application of a loading voltage to the extraction electrode when the temperature value collected by the temperature sensor is greater than or equal to a preset temperature value, so that the extraction electrode extracts the user's tissue fluid based on the loading voltage.

[0076] One embodiment of the present invention provides a tissue fluid extraction control device. According to... Figure 5 As shown, the computer device includes a memory 520 and a processor 510. The memory 520 stores a computer program for controlling the processor 510 to operate and execute the tissue fluid extraction control method provided according to any of the above embodiments.

[0077] The processor 510 is used to execute computer instructions, which can be written using instruction sets of architectures such as x86, Arm, RISC, MIPS, and SSE. The memory 520 includes, for example, ROM (Read-Only Memory), RAM (Random Access Memory), and non-volatile memory such as hard disks, etc., and is not limited thereto.

[0078] The tissue fluid extraction control device is a control device in continuous blood glucose monitoring equipment.

[0079] One embodiment of the present invention provides a computer-readable storage medium having computer program instructions stored thereon. When executed by a processor, the computer program instructions implement the tissue fluid extraction control method provided in any of the above embodiments.

[0080] The various embodiments in this specification are described in a progressive manner. The same or similar parts between the various embodiments can be referred to each other. Each embodiment focuses on describing the differences from other embodiments.

[0081] The foregoing has described specific embodiments of this specification. Other embodiments are within the scope of the appended claims. In some cases, the actions or steps recited in the claims may be performed in a different order than that shown in the embodiments and may still achieve the desired result. Furthermore, the processes depicted in the drawings do not necessarily require the specific or sequential order shown to achieve the desired result. In some embodiments, multitasking and parallel processing are possible or may be advantageous.

[0082] Embodiments of this specification may be systems, methods, and / or computer program products. A computer program product may include a computer-readable storage medium having computer instructions stored thereon for causing a processor to implement various aspects of the embodiments of this specification.

[0083] Computer-readable storage media can be tangible devices capable of holding and storing computer instructions for use by computer instruction execution devices. Computer-readable storage media can be, for example—but not limited to—electrical storage devices, magnetic storage devices, optical storage devices, electromagnetic storage devices, semiconductor storage devices, or any suitable combination of the foregoing. More specific examples (a non-exhaustive list) of computer-readable storage media include: portable computer disks, hard disks, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), static random access memory (SRAM), portable compact disc read-only memory (CD-ROM), digital multifunction disc (DVD), memory sticks, floppy disks, mechanical encoding devices, such as punch cards or recessed protrusions storing computer instructions thereon, and any suitable combination of the foregoing. The computer-readable storage media used herein are not to be construed as transient signals themselves, such as radio waves or other freely propagating electromagnetic waves, electromagnetic waves propagating through waveguides or other transmission media (e.g., light pulses through fiber optic cables), or electrical signals transmitted through wires.

[0084] The computer instructions described herein can be downloaded from computer-readable storage media to various computing / processing devices, or downloaded via a network, such as the Internet, local area network, wide area network, and / or wireless network, to an external computer or external storage device. The network may include copper cables, fiber optic cables, wireless transmission, routers, firewalls, switches, gateway computers, and / or edge servers. A network adapter card or network interface in each computing / processing device receives computer instructions from the network and forwards them to computer-readable storage media within the respective computing / processing device.

[0085] The flowcharts and block diagrams in the accompanying drawings illustrate the architecture, functionality, and operation of possible implementations of systems, methods, and computer program products according to various embodiments of this specification. In this regard, each block in a flowchart or block diagram may represent a module, segment, or portion of computer instructions, which contains one or more executable computer instructions for implementing a specified logical function. In some alternative implementations, the functions marked in the blocks may occur in a different order than those marked in the drawings. For example, two consecutive blocks may actually be executed substantially in parallel, and they may sometimes be executed in reverse order, depending on the functions involved. It should also be noted that each block in the block diagrams and / or flowcharts, and combinations of blocks in the block diagrams and / or flowcharts, can be implemented using a dedicated hardware-based system that performs the specified function or action, or using a combination of dedicated hardware and computer instructions. It will be known to those skilled in the art that implementation in hardware, implementation in software, and implementation using a combination of software and hardware are equivalent.

[0086] Various embodiments of this specification have been described above. These descriptions are exemplary and not exhaustive, nor are they limited to the disclosed embodiments. Many modifications and variations will be apparent to those skilled in the art without departing from the scope of the described embodiments. The terminology used herein is chosen to best explain the principles, practical application, or improvement of the technology in the market, or to enable others skilled in the art to understand the embodiments disclosed herein.

Claims

1. A continuous glucose monitoring device, characterized in that, include: The device includes a control unit, a temperature sensor, a heat-conducting component, and an electrochemical sensor. The temperature sensor includes a heating unit, and the electrochemical sensor includes a extraction electrode. One end of the temperature sensor is connected to the control device, and the other end of the temperature sensor is connected to the heat-conducting component. The heat-conducting component is also connected to the extraction electrode. The control device is used to control the temperature sensor to self-heat through the heating unit, so that the heat generated by self-heating is transferred to the extraction electrode through the heat-conducting component. When the extraction electrode is attached to the user's skin surface, one side of the heat-conducting component is attached to the extraction electrode, and the other side is attached to the user's skin surface, and the contact area between the heat-conducting component and the user's skin surface is smaller than the contact area between the extraction electrode and the user's skin surface.

2. The blood glucose monitoring device according to claim 1, characterized in that, When the extraction electrode is attached to the user's skin surface, the temperature sensor is used to monitor the temperature of the user's skin surface.

3. A method for controlling tissue fluid extraction, characterized in that, The method, applied to a continuous glucose monitoring device as described in any one of claims 1-2, comprises: The temperature value collected by the temperature sensor and the preset temperature value are obtained, wherein the preset temperature value is the lower limit of the temperature range of the user's skin surface when the extraction electrode extracts the user's tissue fluid; If the temperature value collected by the temperature sensor is less than the preset temperature value, the difference between the temperature value collected by the temperature sensor and the preset temperature value is determined. The duty cycle of the PWM signal used to control the heating unit is determined based on the difference between the temperature value collected by the temperature sensor and the preset temperature value. The heating unit of the temperature sensor is controlled to heat up according to the duty cycle of the PWM signal.

4. The method according to claim 3, characterized in that, The step of determining the duty cycle of the PWM signal used to control the heating unit based on the difference between the temperature value collected by the temperature sensor and the preset temperature value includes: If the difference between the temperature value collected by the temperature sensor and the preset temperature value is greater than the preset difference, the duty cycle of the PWM signal is determined to be the first duty cycle. If the difference between the temperature value collected by the temperature sensor and the preset temperature value is less than or equal to the preset difference, the duty cycle of the PWM signal is determined to be the second duty cycle, wherein the first duty cycle is greater than the second duty cycle.

5. The method according to claim 4, characterized in that, When the heating unit of the temperature sensor is controlled to heat based on a first duty cycle, the method further includes: The temperature values ​​collected by the temperature sensor are periodically acquired; If the difference between the temperature value collected by the temperature sensor and the preset temperature value is less than or equal to the preset difference, the duty cycle of the PWM signal is adjusted from the first duty cycle to the second duty cycle.

6. The method according to claim 3, characterized in that, The method further includes: If the temperature value collected by the temperature sensor is greater than or equal to the preset temperature value, the control provides a loading voltage to the extraction electrode.

7. A tissue fluid extraction control device, characterized in that, The tissue fluid extraction control device is the control device in the continuous blood glucose monitoring device as described in any one of claims 1-2, comprising: The acquisition module is used to acquire the difference between the temperature value collected by the temperature sensor and the preset temperature value, wherein the preset temperature value is the lower limit of the temperature range of the user's skin surface when the extraction electrode extracts the user's tissue fluid; The temperature difference determination module is used to determine the difference between the temperature value collected by the temperature sensor and the preset temperature value when the temperature value collected by the temperature sensor is less than the preset temperature value. The duty cycle determination module is used to determine the duty cycle of the PWM signal used to control the heating unit based on the difference between the temperature value collected by the temperature sensor and the preset temperature value. The heating control module is used to control the heating unit of the temperature sensor to heat up according to the duty cycle of the PWM signal.

8. A tissue fluid extraction control device, characterized in that, It includes a memory and a processor, the memory storing a computer program for controlling the processor to operate in order to perform the method according to any one of claims 3 to 6.

9. A computer-readable storage medium having computer program instructions stored thereon, characterized in that, When the computer program instructions are executed by the processor, they implement the method described in any one of claims 3 to 6.

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