一种ROS响应性水凝胶微针及其制备方法和应用
By designing ROS-responsive hydrogel microneedles, multi-level repair of photoaging was achieved, improving component utilization and targeting. This solved the problem that existing technologies could not effectively neutralize deep ROS and inhibit MMPs, and enabled multi-pathway synergistic intervention and dynamic synergistic management of photoaging.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- BEOGENE BIOTECH GUANGZHOU
- Filing Date
- 2026-01-30
- Publication Date
- 2026-07-17
AI Technical Summary
Existing photoaging repair materials cannot effectively neutralize deep ROS, inhibit the continuous activation of MMPs, and are difficult to achieve precise activation and long-term regulation of damaged fibroblasts, lacking the ability to reverse damage to the dermal matrix network.
Design ROS-responsive hydrogel microneedles containing methacrylamide hyaluronic acid, tannic acid, methacrylamide collagen, and liposomes. Protect the active molecules through nano-encapsulation to achieve synergistic effects of UV shielding, MMP activity inhibition, and fibroblast regeneration. Construct a targeted transdermal carrier for dynamic synergistic management.
It achieves multi-level repair of photoaging, improves ingredient utilization and targeting, and forms an integrated "treatment-protection closed loop". At the same time, it achieves differentiated repair and multi-pathway synergistic intervention for different skin layers, solving the problems of "separation of treatment and prevention" and difficulty in sustaining effects in existing technologies.
Smart Images
Figure CN121731199B_ABST