一种刺鲀鱼皮胶原蛋白肽及其提取方法

A method combining calcium-alkali solution pretreatment and acidic hydrothermal treatment with vacuum freeze-drying was used to extract highly bioactive collagen peptides from pufferfish skin. This method solves the problems of high cost and structural damage in existing extraction methods, and achieves efficient utilization of pufferfish skin resources, which is suitable for cosmetics and medical materials.

CN121736085BActive Publication Date: 2026-07-17SANYA INST OF OCEANOGRAPHY OCEAN UNIV OF CHINA

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SANYA INST OF OCEANOGRAPHY OCEAN UNIV OF CHINA
Filing Date
2026-02-28
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies for extracting collagen peptides suffer from high costs, complex processes, and severe damage to peptide structures caused by traditional chemical methods, resulting in poor biocompatibility and bioactivity, making it difficult to effectively utilize pufferfish skin resources.

Method used

A method combining calcium-alkali solution pretreatment and acidic hydrothermal treatment under inert gas protection with vacuum freeze-drying was used to extract collagen peptides from pufferfish skin. This method avoids the high cost of enzymatic hydrolysis and the structural damage caused by chemical methods, thus preserving the natural structure of the peptides.

Benefits of technology

It achieves efficient extraction of highly bioactive collagen peptides under low energy consumption conditions, improving biocompatibility and bioactivity, and is suitable for cosmetics and medical materials.

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Abstract

本发明公开了一种刺鲀鱼皮胶原蛋白肽及其提取方法,包括以下步骤:将脱刺的刺鲀鱼皮加入至钙质碱溶液中进行搅洗,以去除杂蛋白和色素,经过滤和纯水洗涤后得到碱处理后的刺鲀鱼皮;向碱处理后的刺鲀鱼皮中加入酸性提取液,在惰性气体保护条件下进行水热反应,以使得碱处理后的刺鲀鱼皮充分溶解,得到刺鲀鱼皮多肽提取液;将刺鲀鱼皮多肽提取液经过滤、透析和真空冷冻干燥,得到鱼皮胶原蛋白肽。实现了在低能耗条件下,克服了现有酶解法成本高、工艺复杂,以及传统化学法对多肽结构破坏严重的缺点,能够对提取的胶原蛋白肽三螺旋结构进行有效保护,从而应用在化妆品、功能性食品及医用材料领域中。
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