一种可促进糖尿病伤口愈合的药物组合物及其制备方法和应用
By designing a thermosensitive hydrogel carrier that integrates the peptides FP-DW01-Chol and MitoQ, a multi-target synergistic treatment of diabetic wounds was achieved, solving the problem of low wound healing rate in existing technologies and improving wound repair effects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- GUANGZHOU PUGUANG MEDICAL TECH CO LTD
- Filing Date
- 2026-01-14
- Publication Date
- 2026-07-17
AI Technical Summary
Current treatment options cannot effectively integrate and regulate the inflammatory response, angiogenesis, and angiogenesis capacity of macrophages, resulting in low wound healing rates in diabetic patients and problems such as drug resistance and unstable efficacy.
We designed a fusion peptide FP-DW01-Chol, combined with angiopoietin-2 mimic peptide and mitochondrial targeter MitoQ, to achieve multi-component synergistic delivery via a thermosensitive hydrogel carrier, thereby regulating inflammation, angiogenesis and metabolic disorders.
It significantly improves the healing effect of diabetic wounds, reduces the frequency of drug administration, increases the thickness of new epithelium and vascular density, reduces the level of inflammatory factors, and enhances the wound repair ability.
Smart Images
Figure CN121736121B_ABST