A long-acting care low-foam bacteriostatic infant bath foam based on sophorolipid

Abstract

The application discloses a long-acting care low-foam bacteriostatic infant bath foam based on sophorolipid, and belongs to the technical field of infant washing and caring products. The bath foam is composed of the following components in percentage by mass: sophorolipid 10-20%, amino acid surfactant 3-8%, glycerol 8-10%, beta-glucan 1-5%, panthenol 0.5-1%, rosemary essential oil microcapsule 0.1-0.5%, camphor tree leaf extract microcapsule 1-3%, and the rest is water. The bath foam prepared by the application has excellent cleaning performance and can effectively remove dirt and excess grease on the surface of infant skin. The sophorolipid is used as the main surfactant, fully plays the natural bacteriostatic, low-foam mild and skin-friendly characteristics, cooperates with the rosemary essential oil microcapsule and the camphor tree leaf extract microcapsule, realizes synergistic bacteriostasis, improves the bacteriostatic effect and the bacteriostatic duration, and solves the problems of short bacteriostatic duration and strong irritability of the existing infant bath foam.

Description

Technical Field

[0001] This invention belongs to the technical field of infant and child care products, specifically relating to a long-lasting, low-foaming, antibacterial infant and child bath wash based on sophorolipids. Background Technology

[0002] Infant skin, as an immature physiological barrier, has a stratum corneum thickness only 1 / 3 to 1 / 2 that of adults, and sebum secretion less than 50% of that of adults. Furthermore, its pH value remains in the neutral to slightly acidic range (5.0-6.5), resulting in weak water retention and poor resistance to external stimuli. This makes it susceptible to chemical and microbial invasion, leading to dryness, itching, allergies, and even infections. This unique physiological characteristic dictates that infant and toddler skincare products must break away from the traditional formulation logic of adult products. The core research and development principles should be "extremely gentle, absolutely safe, and functionally appropriate," achieving effective cleansing while avoiding damage to the skin barrier, and simultaneously providing auxiliary functions such as antibacterial and moisturizing.

[0003] While commercially available baby care products generally claim to be "mild and non-irritating," they still have several technical problems: First, their formulas commonly contain synthetic preservatives (such as parabens, methylisothiazolinone / methylchloroisothiazolinone complexes), artificial fragrances, and pigments. Although these substances can extend the product's shelf life and enhance the sensory experience, they have been proven to be one of the main causes of skin allergies in infants, and long-term exposure may disrupt the skin's microecological balance. Second, their surfactant systems often rely on synthetic anionic surfactants such as sodium lauryl ether sulfate (SLES) and sodium α-olefin sulfonate (AOS). First, some products contain active ingredients that produce rich foam but have strong penetrability, making them prone to remaining on the skin's surface, damaging the integrity of the sebum film, and leading to dry and tight skin. Second, the application of natural ingredients has limitations. Existing products often contain plant extracts such as calendula and chamomile, which are mostly single-ingredient products with limited functions and poor stability. Bio-based ingredients, which have both gentle cleansing and natural antibacterial effects, have not yet been widely used. Third, some products sacrifice cleansing power in pursuit of low irritation, making it difficult to effectively remove protein and sebum dirt from the surface of infants' skin. Excessive foam can also make rinsing difficult, increasing the risk of residual irritation.

[0004] Biosurfactants, as a novel green raw material in the personal care field in recent years, have gradually become a research and development hotspot for high-end baby care products due to their natural origin, biodegradability, and mild properties. Sophorolipids, a biosurfactant produced by yeast fermentation, not only possess excellent emulsifying, dispersing, and cleaning abilities, but also have advantages such as antibacterial and anti-inflammatory properties, low irritation, and biocompatibility. The hydrophilic and hydrophobic groups in its molecular structure can achieve efficient cleaning while reducing penetration damage to skin cells, and it can be completely degraded by microorganisms, making it environmentally friendly. However, current technologies do not yet include baby care compositions with sophorolipids as the core functional component. Most products only use it in small amounts as an auxiliary additive, failing to fully utilize its core advantages in gentle cleaning, natural antibacterial properties, and low-foaming, easy-rinsing characteristics, and have not formed a compound system highly adapted to the needs of baby skin. Therefore, developing a baby care composition with sophorolipids as the main ingredient, synergistically formulated with mild auxiliary ingredients, and possessing low-foaming, non-toxic, biodegradable, long-lasting gentle cleaning, antibacterial, and moisturizing functions, is key to overcoming the shortcomings of existing technologies and meeting the high-end market demand. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a long-lasting, low-foaming, antibacterial baby bath wash based on sophorolipids.

[0006] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows:

[0007] A long-lasting, low-foaming, antibacterial baby bath wash based on sophorolipids, wherein the bath wash is composed of the following components by weight percentage: 10-20% sophorolipids, 3-8% amino acid surfactants, 8-10% glycerin, 1-5% β-glucan, 0.5-1% panthenol, 0.1-0.5% rosemary essential oil microcapsules, 1-3% camphor leaf extract microcapsules, and the remainder is water.

[0008] Furthermore, the shower gel is composed of the following components by mass percentage: 15-20% sophorolipid, 5-8% amino acid surfactant, 9-10% glycerin, 3-5% β-glucan, 0.5-1% panthenol, 0.3-0.5% rosemary essential oil microcapsules, 2-3% camphor leaf extract microcapsules, and the remainder is water.

[0009] Furthermore, the shower gel is composed of the following components by mass percentage: 20% sophorolipid, 8% amino acid surfactant, 10% glycerin, 5% β-glucan, 0.5% panthenol, 0.5% rosemary essential oil microcapsules, 3% camphor leaf extract microcapsules, and the remainder is water.

[0010] Furthermore, the capsule material of the rosemary essential oil microcapsules and camphor leaf extract microcapsules is a maltodextrin-gum arabic compound capsule material with a capsule diameter of 1-5 μm and an encapsulation rate of ≥85%.

[0011] Furthermore, the camphor tree leaf extract was prepared by water extraction and alcohol precipitation, with an extraction temperature of 60-80℃ and an extraction time of 2-3 hours.

[0012] Furthermore, the amino acid surfactant is selected from one or both of sodium cocoyl glycinate and sodium lauroyl sarcosinate.

[0013] Furthermore, the preparation method of the sophorolipid-based long-lasting, low-foaming, antibacterial baby bath wash includes the following steps:

[0014] (1) Heat deionized water, add glycerol, β-glucan and panthenol, and stir until completely dissolved to obtain an aqueous phase;

[0015] (2) Add sophorolipid and amino acid surfactant to the aqueous phase and stir until the system is uniform and transparent;

[0016] (3) Add rosemary essential oil microcapsules and camphor leaf extract microcapsules, and continue stirring;

[0017] (4) Adjust the pH of the system, cool it down, let it stand, filter it, and fill it to obtain the finished product.

[0018] Furthermore, in step 1), the heating temperature is 45-55℃.

[0019] Further, in step 4), adjust the pH to 5.5-6.0.

[0020] Compared with the prior art, the present invention has the following advantages:

[0021] (1) This invention uses sophorolipid as the main surfactant, giving full play to its natural antibacterial, low-foaming, mild, and skin-friendly properties. Sophorolipid can not only achieve gentle cleansing, but also inhibit common pathogens on infant skin. At the same time, it works synergistically with rosemary essential oil microcapsules and camphor leaf extract microcapsules to achieve synergistic antibacterial effect, improve the antibacterial effect and duration, and solve the problems of short-acting antibacterial effect and strong irritation of existing infant bath products.

[0022] (2) The camphor tree leaf extract microcapsules used in this invention have more stable antibacterial and anti-inflammatory effects, and are gentle and non-irritating; replacing the tea tree essential oil microcapsules with rosemary essential oil microcapsules has better antibacterial effects and lower irritation, making it suitable for infant skin. At the same time, the microcapsule encapsulation technology enables the slow release of antibacterial components, prolonging the long-lasting antibacterial effect.

[0023] (3) The sophorolipid and amino acid surfactant used in this invention work synergistically to achieve low foaming characteristics, with fine foam that is easy to rinse and leaves no residue, thus avoiding the irritation of the delicate skin of infants and children by residual ingredients and reducing the risk of skin redness and itching.

[0024] (4) The shower gel prepared by the present invention has excellent cleaning performance and can effectively remove dirt and excess oil from the surface of infant skin. At the same time, glycerin, β-glucan and sophorolipid work together to lock in skin moisture, repair the skin barrier, achieve long-lasting moisturization, relieve dry skin of infants, and enhance skin resistance. The use of panthenol can effectively increase its moisturizing performance. Attached Figure Description

[0025] Figure 1 These are comparison diagrams of foam height between Examples 1-3 and Comparative Examples 1-2 of this application;

[0026] Figure 2 These are comparison diagrams of bubble stabilization in Examples 1-3 and Comparative Examples 1-2 of this application;

[0027] Figure 3 This is a comparison chart of the detergency of Examples 1-3 and Comparative Examples 1-2 of this application;

[0028] Figure 4 These are comparison images of the moisturizing effects of Examples 1-3 and Comparative Examples 1-2 of this application. Detailed Implementation

[0029] The present invention will be further illustrated below with reference to specific embodiments. These embodiments are implemented based on the technical solutions of the present invention, and it should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0030] In the following examples, the raw materials and abbreviations used are as follows: Sophorolipid: SpecBio®SL D500, sourced from Nanjing SpecBio Biotechnology Co., Ltd., commercially available.

[0031] The encapsulation materials of the rosemary essential oil microcapsules and camphor leaf extract microcapsules used in the following examples are maltodextrin-gum arabic compound encapsulation materials with a diameter of 1-5 μm and an encapsulation rate of ≥85%.

[0032] The following examples illustrate the preparation method of camphor leaf extract:

[0033] 1) According to the material-liquid ratio of camphor leaf powder to deionized water = 1:10~1:15 (g:mL), put the camphor leaf powder into a constant temperature water bath extraction pot and stir to mix evenly; raise the temperature to 60-80℃, maintain the constant temperature and stir at a low speed of 60-80r / min for 2-3h, during which a small amount of deionized water is added to make up for evaporation loss and ensure the stability of the material-liquid ratio; after extraction, first use a 200-mesh nylon filter cloth for coarse filtration to remove camphor leaf residue; then use a vacuum filter (filter membrane pore size 0.45μm) for fine filtration to obtain a clear, impurity-free camphor leaf aqueous extract.

[0034] 2) Place the camphor tree leaf aqueous extract in a room temperature stirring tank, and slowly add food-grade anhydrous ethanol dropwise at 50 r / min until the volume fraction of ethanol in the system reaches 70-80%; after the addition is completed, continue stirring for 15 min, seal and place in a refrigerated environment at 4℃ for 12-24 h.

[0035] 3) Take the supernatant after alcohol precipitation, filter it with a plate and frame filter to remove precipitated impurities, and obtain the purified alcohol precipitation solution of camphor tree leaves; add the purified solution to a rotary evaporator, set the concentration temperature to 45-50℃ and the vacuum degree to -0.08~-0.09MPa, and carry out low-temperature reduced pressure concentration until the solid content reaches 40-50% viscous paste.

[0036] Example 1

[0037] A long-lasting, low-foaming, antibacterial baby bath wash based on sophorolipids has the following formula by weight percentage: 10% sophorolipids, 3% sodium cocoyl glycinate, 8% glycerin, 1% β-glucan, 0.1% rosemary essential oil microcapsules, 1% camphor leaf extract microcapsules, and 76.9% deionized water; the pH is adjusted to 5.5 with citric acid.

[0038] The preparation method includes the following steps:

[0039] (1) Take 76.9% deionized water, heat it to 45°C, add 8% glycerol and 1% β-glucan, stir at 300 r / min until completely dissolved, and obtain the aqueous phase;

[0040] (2) Add 10% sophorolipid and 3% sodium cocoyl glycinate to the aqueous phase, stir at 45°C and 300r / min for 30min until the system is uniform and transparent;

[0041] (3) Add 0.1% rosemary essential oil microcapsules and 1% camphor leaf extract microcapsules, stir at 40℃ and 200r / min for 20min until evenly dispersed;

[0042] (4) Adjust the pH to 5.5 with citric acid, stir for 10 minutes, cool to below 30°C, let stand for 15 minutes, filter and fill to obtain shower gel.

[0043] Example 2

[0044] A long-lasting, low-foaming, antibacterial baby bath wash based on sophorolipids has the following formula by weight percentage: 15% sophorolipids, 5% sodium lauroyl sarcosinate, 9% glycerin, 3% β-glucan, 0.3% rosemary essential oil microcapsules, 2% camphor leaf extract microcapsules, 1% panthenol, and 64.7% deionized water; the pH is adjusted to 5.8 with triethanolamine.

[0045] The preparation method includes the following steps:

[0046] (1) Take 64.7% deionized water, heat it to 50°C, add 9% glycerol, 3% β-glucan and 1% panthenol, stir at 400 r / min until completely dissolved to obtain the aqueous phase;

[0047] (2) Add 15% sophorolipid and 5% sodium lauroyl sarcosinate to the aqueous phase, stir at 50°C and 400r / min for 35min until the system is uniform and transparent;

[0048] (3) Add 0.3% rosemary essential oil microcapsules and 2% camphor leaf extract microcapsules, stir at 42℃ and 250r / min for 25min until evenly dispersed;

[0049] (4) Adjust the pH to 5.8 with triethanolamine, stir for 12 min, cool to below 30°C, let stand for 18 min, filter and fill to obtain shower gel.

[0050] Example 3

[0051] A long-lasting, low-foaming, antibacterial baby bath wash based on sophorolipids has the following formula by weight percentage: 20% sophorolipids, 8% sodium cocoyl glycinate and sodium lauroyl sarcosinate (weight ratio 1:1), 10% glycerin, 5% β-glucan, 0.5% rosemary essential oil microcapsules, 3% camphor leaf extract microcapsules, 0.5% panthenol, and 52.5% deionized water; the pH is adjusted to 6.0 with citric acid.

[0052] The preparation method includes the following steps:

[0053] (1) Take 52.5% deionized water, heat it to 55°C, add 10% glycerol, 5% β-glucan and 0.5% panthenol, stir at 500 r / min until completely dissolved to obtain the aqueous phase;

[0054] (2) Add 20% sophorolipid and 8% compound amino acid surfactant to the aqueous phase, stir at 55℃ and 500r / min for 40min until the system is uniform and transparent;

[0055] (3) Add 0.5% rosemary essential oil microcapsules and 3% camphor leaf extract microcapsules, stir at 45℃ and 300r / min for 30min until evenly dispersed;

[0056] (4) Adjust the pH to 6.0 with citric acid, stir for 15 minutes, cool to below 30°C, let stand for 20 minutes, filter and fill to obtain shower gel.

[0057] Comparative Example 1

[0058] The difference from Example 2 is that sophorolipid is replaced with sodium lauryl ether sulfate (AES), and the natural antibacterial combination consists of 0.3% tea tree oil microcapsules and 2% honeysuckle extract, while the other components and contents remain unchanged, resulting in a shower gel.

[0059] Comparative Example 2

[0060] The difference from Example 2 is that rosemary essential oil microcapsules and camphor leaf extract microcapsules are not added; only 15% sophorolipid is added as an antibacterial component, while the other components and their contents remain unchanged, resulting in a shower gel.

[0061] Example 4

[0062] The performance of the shower gels prepared in Examples 1-3 and Comparative Examples 1-2 was tested.

[0063] 1. Long-lasting antibacterial test

[0064] Test method: Multiple time points were set for testing (e.g., 0h, 2h, 6h, 24h) to verify the persistence of antibacterial effect. Standard strains (e.g., Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 25922) were used to avoid potential risks to infants. The test concentration simulated the actual use dilution (usually 1:10). The results are shown in Table 1.

[0065] Table 1. Results of long-lasting antibacterial test of the shower gels prepared in Examples 1-3 and Comparative Examples 1-2

[0066]

[0067] Table 1 shows that the formulation containing 10-20% sophorolipid, 3-8% amino acid surfactant, 8-10% glycerol, 1-5% β-glucan, 0.1-0.5% rosemary essential oil microcapsules, and 1-3% camphor leaf extract microcapsules all exhibited inhibitory effects on Staphylococcus aureus and Escherichia coli. Example 3 showed a stronger inhibitory effect on Staphylococcus aureus and Escherichia coli. In Comparative Examples 1-2, the introduction of sophorolipid and rosemary essential oil microcapsules enhanced the inhibitory effect of the compound on Staphylococcus aureus and Escherichia coli.

[0068] 2. Low-foaming performance test

[0069] Rinsing performance test: Prepare 1 L of 5% aqueous solutions using Examples 1-3 and Comparative Examples 1-2 respectively; immerse each hand in the two sample solutions, wash hands for 1 minute, and then drain; take 100 mL of water from each hand and rinse hands separately, collect the rinse water in a stoppered graduated cylinder, shake up and down 5 times, and observe the foaming state. Results are shown in Table 2 and... Figure 1-2 .

[0070] Table 2. Test results of low-foaming performance of the shower gels prepared in Examples 1-3 and Comparative Examples 1-2

[0071]

[0072] From Table 2 and Figure 1-2 It can be seen from the foam performance tests of different samples that the foam performance tends to decrease as the concentration of sophorolipid increases (the smaller the foam volume, the higher the defoaming rate, and the more it tends to be low-foaming). Overall, the foam performance of Example 3 is the lowest.

[0073] 3. Cleaning performance test

[0074] The specific method is as follows:

[0075] Hard water preparation: The solution prepared in the experiment used 250 mg / kg hard water. The preparation method is as follows: Weigh 16.70 g of calcium chloride and 20.37 g of magnesium chloride to prepare 10.0 L, which is 2500 mg / kg hard water. When using, take 1.0 L to dilute to 10.0 L, which is 250 mg / kg hard water.

[0076] Whiteness Measurement: Select the required JB series test piece variety, cut the soiled cloth to be tested into test pieces, stack the test pieces of the same category, and use a whiteness meter to read the whiteness value before and after washing one by one from 457mm. For the whiteness before washing, take two points on each side of the test piece to measure the whiteness value, and take the average of four measurements as the whiteness value F1 of the test piece before washing; for the whiteness value after washing, take two points on each side of the test piece to measure the whiteness value, and take the average of four measurements as the whiteness value F2 of the test piece before washing.

[0077] Stain Removal Washing Test: 1) The test was conducted in a vertical stain remover. The stain removal baths were numbered and fixed, and preheated to 30℃±1℃ for a period of time. During the test, 1L of a 0.2% concentration test solution was prepared by mixing the sample with standard laundry detergent using 250mg / kg hard water (preheated to approximately 30℃). This solution was poured into the corresponding stain removal bath, the impeller was installed, and the instrument was adjusted to maintain the test temperature at 30℃±1℃. 2) The test pieces whose whiteness F1 was measured in the previous step were placed into each bath. The agitation was started, maintaining a stirring speed of 120r / min (angular velocity 220π / min). Washing continued for 20 minutes and then stopped. 3) The test pieces from each stain removal bath were combined and poured into the inner tub of the rinse tank. The water was drained, and the inner tub was placed into the rinse tank. 1500ml of clean water was poured in, the inner tub was rotated for 30 seconds, the rinse water was drained, and 1500ml of clean water was added again. The rinsing process was repeated once more. After draining the rinse water, manually spin-dry the inner drum for 15 seconds. Remove the rinsed and spun-dry sample, hang it to air dry at room temperature, and then measure the whiteness F2 following the steps above. 4) Calculate the stain removal value R = F2 - F1. The results are shown in Table 3 and... Figure 3 .

[0078] Table 3. Test results of the cleaning performance of the shower gels prepared in Examples 1-3 and Comparative Examples 1-2

[0079]

[0080] From Table 3 and Figure 3 It can be seen that, through testing the detergency values ​​of different samples, the detergency of Example 3 on carbon black soiled cloth is similar to that of Example 2, and slightly lower than that of Comparative Example 1; for both protein soiled cloth and carbon black soiled cloth, Example 3 is superior to Examples 1-2 and Comparative Examples 1-2; overall, as the concentration of sophorolipid increases, the detergency value shows an upward trend (the higher the detergency value, the better the cleaning effect), and in summary, Example 3 has the best cleaning effect.

[0081] 4. Moisturizing performance test

[0082] Clean the arms and rest for 20 minutes in a constant temperature (20℃-25℃) and constant humidity (40%-60%) environment; mark 6 test sites on the inner side of both forearms; collect transdermal water loss data at 0 h; apply the corresponding sample (0.014 g / cm³) to each site. 2 After applying the product evenly, let it stand for three minutes, then rinse thoroughly with running water and gently dry. Transdermal water loss data were collected at 1 hour, 3 hours, 5 hours, and 7 hours. Results are shown in Table 4. Figure 4 .

[0083] Table 4. Results of moisturizing performance tests on the shower gels prepared in Examples 1-3 and Comparative Examples 1-2

[0084]

[0085] From Table 4 and Figure 4 It can be seen that by testing the transdermal water loss values ​​of different samples at different time periods, the transdermal water loss value shows a decreasing trend as the concentration of sophorolipid increases (the smaller the transdermal water loss value, the better the moisturizing effect). Overall, the moisturizing effect of Example 3 is the best.

[0086] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A long-lasting, low-foaming, antibacterial baby bath wash based on sophorolipids, with the following formula by weight percentage: 20% sophorolipids, 8% sodium cocoyl glycinate and sodium lauroyl sarcosinate, 10% glycerin, 5% β-glucan, 0.5% rosemary essential oil microcapsules, 3% camphor leaf extract microcapsules, 0.5% panthenol, and 52.5% deionized water; the pH is adjusted to 6.0 with citric acid; the mass ratio of sodium cocoyl glycinate to sodium lauroyl sarcosinate is 1:

1. The preparation method includes the following steps: (1) Take 52.5% deionized water, heat it to 55℃, add 10% glycerol, 5% β-glucan and 0.5% panthenol, stir at 500r / min until completely dissolved to obtain the aqueous phase; (2) Add 20% sophorolipid, 8% sodium cocoyl glycinate and sodium lauroyl sarcosinate to the aqueous phase, stir at 55℃ and 500r / min for 40min until the system is uniform and transparent; (3) Add 0.5% rosemary essential oil microcapsules and 3% camphor leaf extract microcapsules, stir at 45℃ and 300r / min for 30min until evenly dispersed; (4) Adjust the pH to 6.0 with citric acid, stir for 15 minutes, cool to below 30°C, let stand for 20 minutes, filter and fill to obtain shower gel; The capsules for rosemary essential oil and camphor leaf extract are made of maltodextrin-gum arabic compound, with a capsule diameter of 1-5 μm and an encapsulation rate of ≥85%. The camphor leaf extract is prepared by water extraction and alcohol precipitation at an extraction temperature of 60-80℃ for 2-3 hours. The sophorolipid is of the SpecBio®SL D500 type.

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