界面粘合组合物及其制备方法与应用
By combining calcium salts, phosphate compounds, and reaction enhancers in the interfacial adhesive composition, the problem of limited fixation effect in comminuted fractures is solved, providing immediate and durable fracture fixation. It is biocompatible, non-toxic, and harmless, and suitable for fracture repair and bone adhesion.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JIANGSU DEVICELAND MEDICAL INSTR CORP LTD
- Filing Date
- 2026-03-05
- Publication Date
- 2026-07-17
AI Technical Summary
Existing fracture repair materials have limited fixation effects in comminuted fractures. Traditional metal internal fixation devices require a second surgery for removal. CA adhesives are non-degradable and highly toxic, while polymer materials have poor degradability and insufficient biocompatibility.
Develop an interfacial adhesive composition comprising a calcium salt, a phosphate compound, and a reaction enhancer, which provides immediate fixation and long-term rigid interfacial adhesion by mixing and applying or injecting it onto a bone fracture surface. The composition utilizes phosphate groups and a biotemplate to promote mineralization, while an acid-base neutralization reaction provides energy and a nucleating agent.
It achieves immediate and lasting fixation of the fracture site, has high biocompatibility, a degradation cycle of more than six months, is suitable for splicing and repairing comminuted fractures, has high bonding strength and is non-toxic and harmless during degradation.
Smart Images
Figure CN121774818B_ABST