一种工程化外泌体包覆凝聚体液滴的靶向药物载体及其制备方法与应用
By constructing an engineered exosome-encapsulated condensate droplet composite system, the problems of insufficient drug loading and poor targeting in existing drug delivery systems have been solved, achieving efficient drug loading and targeted delivery, improving therapeutic effects and reducing side effects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- FUDAN UNIVERSITY
- Filing Date
- 2026-01-08
- Publication Date
- 2026-07-17
AI Technical Summary
Existing drug delivery systems suffer from limited drug loading capacity, complex preparation processes, insufficient biocompatibility, and poor targeting, making it particularly difficult to achieve efficient targeted delivery in cancer treatment.
By constructing an engineered exosome-encapsulated condensate droplet composite system, positively charged cationic peptides and negatively charged DNA are used to form condensate droplets. Specific antibodies are then modified on the exosome surface to achieve efficient drug encapsulation and targeted delivery.
It achieves efficient drug delivery and targeted recognition, significantly improves drug accumulation and efficacy in target cells, reduces the risk of side effects in non-target cells, and is suitable for drug delivery for the treatment of various diseases, especially tumors.
Smart Images
Figure CN121774908B_ABST