重组细胞构建及功能验证系统
By integrating reactor arrays, feeding modules, sampling modules, and detection modules, the system solves the problem of real-time monitoring of hydroxylation modification of recombinant cell proteins in existing technologies, enabling precise dynamic control of the quantitative properties of target proteins and improving culture efficiency and the yield and quality of recombinant proteins.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI INNOGEN PHARM TECH CO LTD
- Filing Date
- 2026-03-10
- Publication Date
- 2026-07-17
AI Technical Summary
The existing recombinant cell construction and screening process makes it difficult to monitor the cells' ability to modify proteins by hydroxylation in real time, which leads to the process parameter optimization relying on trial and error based on experience and makes it impossible to capture the optimal cell physiological window.
An integrated system comprising a reactor array, a feeding module, a sampling module, and a detection module is employed to achieve precise dynamic control of key quality attributes of the target protein through online sampling, real-time detection, and a closed-loop feeding feedback mechanism.
This technology enables real-time monitoring and dynamic control of the post-translational modification state of recombinant cells, improving culture efficiency and the yield and quality stability of recombinant proteins.
Smart Images
Figure CN121801703B_ABST