一种基于食品肠衣的蛋白基生物材料在组织工程中的应用
By employing gentle enzymatic or acid extraction and endotoxin removal processes, waste casings from the food industry are transformed into multifunctional biomaterials. This solves the problems of high cost, complex processes, and limited applications of collagen-based materials in existing technologies, enabling efficient and flexible applications of biomaterials.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HUAZHONG UNIV OF SCI & TECH
- Filing Date
- 2026-03-12
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies lack gentle extraction methods to convert waste casings, a byproduct of the food industry, into active proteins, and fail to effectively remove endotoxins. This results in high costs, complex processes, and limited application forms for collagen-based biomaterials, making it difficult to meet the safety requirements of biomedical materials.
Collagen from edible animal casings is extracted using a mild enzymatic or acidic method. Endotoxins are removed by rinsing with surfactants and incubating with sucrose. Collagen fibers that can self-assemble under physiological conditions are then prepared and formed into a rapidly resolvable lyophilized powder for use in three-dimensional cell culture, surgical sutures, and tissue engineering scaffolds.
This technology enables the low-cost and efficient transformation of waste casings into multifunctional biomaterials that meet the performance and form requirements of different tissue engineering applications. It avoids the problems of high-temperature degradation and endotoxin residues associated with traditional methods, and provides flexible application forms and high-value-added products.
Smart Images
Figure CN121802003B_ABST