Method for bioinformatics alignment analysis of gastric cancer pathogenic gene sequence
By constructing a dynamic alignment model that matches a multidimensional topological reference map of gastric cancer with an etiological fingerprint map, the problem of missed and false detections in the alignment of pathogenic gene sequences of gastric cancer using a linear reference genome was solved, achieving highly sensitive and specific variant identification.
CN121811972BActive Publication Date: 2026-07-24FUJIAN PROVINCIAL HOSPITAL
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- FUJIAN PROVINCIAL HOSPITAL
- Filing Date
- 2026-03-05
- Publication Date
- 2026-07-24
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Figure CN121811972B_ABST
Abstract
The present application relates to the technical field of bioinformatics and genome sequencing data processing, in particular to a biological information alignment analysis method for stomach cancer pathogenic gene sequence, comprising: obtaining gene sequencing data of a target sample, loading a preset stomach cancer multi-dimensional topological reference graph, and loading a preset mutation feature vector library; generating a feature frequency distribution, matching a preset etiology fingerprint to determine the pathogenic background type of the target sample; constructing a dynamic weight multi-modal graph alignment model; calculating the fitting degree of the optimal alignment path and the theoretical variation path based on etiology deduction to generate a pathogenic confidence score; and generating a corrected second topological reference graph; the present application effectively overcomes the limitations of linear alignment in processing complex structural variations, significantly improving the sensitivity of variation identification.
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