可阻断TNF-α反向信号的TRAF1拮抗肽及其应用
By designing the TRAF1 antagonistic peptide TAP to bind to tmTNF-α and block its reverse signal, the problem of the difficulty in inhibiting the reverse signal of tmTNF-α in the existing technology was solved, and the proliferation and invasiveness of tumor cells with high expression of tmTNF-α were inhibited, thereby improving the sensitivity to chemotherapy and regulating the cell cycle.
CN121824726BActive Publication Date: 2026-07-17TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
- Filing Date
- 2026-03-11
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing technologies are unable to effectively block the reverse signaling of transmembrane TNF-α (tmTNF-α), leading to enhanced proliferation and invasiveness of tumor cells that highly express tmTNF-α, as well as increased drug resistance.
Method used
A TRAF1 antagonistic peptide (TAP) was designed to inhibit the NF-κB signaling pathway by binding to the intracellular domain of tmTNF-α, thereby blocking the reverse signaling of tmTNF-α and inhibiting the proliferation and invasiveness of tumor cells.
Benefits of technology
It significantly inhibited the proliferation and invasiveness of tumor cells that highly express tmTNF-α, improved chemosensitivity, weakened tumor clonogenicity and invasiveness, regulated the cell cycle, and inhibited the NF-κB signaling pathway.
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Figure CN121824726B_ABST
Abstract
本发明涉及靶向拮抗TNF‑α反向信号的TRAF1拮抗肽及其应用。本发明基于tmTNF‑α反向信号通路的原创性研究，利用与其结合的TRAF1锌指结构域，合成肽段（TRAF1拮抗肽TAP）。该拮抗肽能够结合tmTNF‑α胞内段，通过抑制tmTNF‑α反向信号，抑制NFkB信号通路，提高tmTNF‑α表达阳性肿瘤对化疗敏感性，且减弱肿瘤克隆形成及侵袭能力。
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