A lentivirus vector and its construction method and application
CN121826065BActive Publication Date: 2026-08-28SHENZHEN ZHUOQIAO MEDICAL HEALTH TECHNOLOGY CO LTD
Patent Information
- Application Number
- CN202512050893.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-31
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2045-12-31
AI Technical Summary
Technical Problem
[0006]本发明的目的是为了克服VSV-G包膜病毒存在较高免疫原性、在血清中的稳定性较差的问题，提供一种慢病毒载体及其构建方法和应用
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Figure CN121826065B_ABST
Abstract
The application relates to the field of biological medicine, and discloses a lentivirus vector and a construction method and application thereof, the lentivirus vector comprising: (1) an antigen-targeting artificial protein receptor, the receptor comprising a target cell surface antigen binding domain and a transmembrane domain; (2) a mutated Marabavirus envelope protein; and (3) an expression cassette, the expression cassette comprising a heterologous transgene. The new lentivirus vector based on the mutated Marabavirus envelope provided by the application can realize specific infection of target cells in vitro and in vivo. Compared with a vesicular stomatitis virus envelope VSV-G, the lentivirus vector constructed based on the mutated Marabavirus envelope protein has better stability in serum, higher efficiency of specific infection of target cells, and more prominent drug efficacy in a mouse tumor model.
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Citation Information
Patent Citations
In VIVO lentivirus animal models
WO2024207008A2
Mutated vesicular virus envelope protein and use thereof in lentiviral vector packaging
WO2025247369A1