Genetically modified cells comprising heterologous nucleic acid molecules inserted in CD5 locus region

By inserting heterologous nucleic acid molecules into the CD5 locus and editing them using the CRISPR system, the risk of unwanted cell characteristics caused by heterologous nucleic acid molecule insertion is resolved, improving the therapeutic effect of cells, especially in cancer treatment.

CN121844048APending Publication Date: 2026-04-10VICTORIA BIOTHERAPEUTICS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-05-23
Publication Date
2026-04-10

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Abstract

Embodiments provide a cell comprising a heterologous nucleic acid molecule inserted at a CD5 locus. Also provided herein are compositions comprising the cells, as well as methods of making and using the cells and compositions.
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