一种喹喔啉基有机硼类染料及其制备方法和应用
By constructing an N,O type polydentate ligand skeleton of 2,3-dihydrazinoquinoxaline and introducing aromatic groups to form a three-dimensional structure, the problems of small Stokes shift and aggregation-induced quenching of existing organoboron fluorescent dyes were solved, achieving high molar absorbance and significant aggregation-induced emission effect, which is suitable for bioimaging and photothermal therapy.
CN121851045BActive Publication Date: 2026-07-17HANGZHOU NORMAL UNIVERSITY
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HANGZHOU NORMAL UNIVERSITY
- Filing Date
- 2026-03-18
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing organoboron fluorescent dyes suffer from small Stokes shifts and aggregation-induced quenching, which limits their application in solid-state and biological high-concentration environments.
Method used
By constructing a novel N,O-type polydentate ligand skeleton of 2,3-dihydrazinoquinoxaline, and utilizing its unique spatial geometry, aromatic groups are introduced to form a three-dimensional spatial structure, enabling the precise construction and separation of cis and trans isomers.
Benefits of technology
It achieves large Stokes shift (over 100 nm), reduces self-absorption interference, and improves photostability and fluorescence signal intensity, making it suitable for imaging complex biological environments.
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Figure CN121851045B_ABST
Abstract
本发明公开一种喹喔啉基有机硼类染料及其制备方法和应用，所述喹喔啉基有机硼类染料的结构式具有顺式（syn‑）和反式（anti‑）两种空间同分异构体；所述染料基于2,3‑二肼基喹喔啉与芳香醛类化合物构建的新型N,O型螯合骨架，通过与硼酸衍生物配位获得，采用一锅两步法，具有合成路径简便、无需复杂纯化、底物适用性强及易于规模化生产等优点。本发明所述喹喔啉基有机硼类染料展现出优异的光物理性质，斯托克斯位移普遍超过100 nm，有效降低了荧光自吸收干扰；同时具有高摩尔吸光系数、高荧光量子产率及优异的光稳定性，在生物成像、光学传感及光诊疗等领域具有潜在的应用价值。
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