一种能穿透肠道屏障的耐药沙门氏菌抗菌肽及应用
By designing antimicrobial peptides with an α-helical amphiphilic structure, the problems of antibiotic resistance and host cell safety have been solved, achieving efficient and safe Salmonella eradication. These peptides are suitable as feed additives and can be applied in poultry farming to significantly improve survival rates and reduce the risk of drug resistance.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HUAZHONG AGRI UNIV
- Filing Date
- 2026-03-17
- Publication Date
- 2026-07-17
AI Technical Summary
Existing antibiotics are prone to leading to increased drug resistance and drug residues when treating Salmonella infections, and conventional antimicrobial peptides have shortcomings in terms of oral stability and host cell safety.
An antimicrobial peptide with an α-helical amphiphilic structure and a ditryptophan motif has been designed. It can stably pass through the gastrointestinal tract, efficiently eliminate intracellular Salmonella, and is safe for host cells. The amino acid sequence is SEQ ID NO.1. It is suitable for feed additives and can be produced on a large scale through solid-phase synthesis.
This antimicrobial peptide completely kills bacteria within 2 hours at 2×MIC, maintains a low MIC against multidrug-resistant bacteria, and shows no significant increase in MIC after 20 consecutive passages. It has no obvious toxicity to host cells, leaves no residue after feeding, significantly improves animal survival rate, and is feasible for industrialization.
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