一种基于分级锚定探针的结直肠癌Septin9基因甲基化检测试剂盒
By using a hierarchical anchored probe system and a functionalized nuclear pore membrane sensor, the issues of specificity, stability, and efficiency in Septin9 gene methylation detection have been resolved, enabling efficient and convenient detection of colorectal cancer.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- UNION BIOTECH TIANJIN
- Filing Date
- 2026-03-17
- Publication Date
- 2026-07-17
AI Technical Summary
Existing Septin9 gene methylation detection technologies have shortcomings in terms of specificity, stability, and detection efficiency, making it difficult to meet the needs of early diagnosis of colorectal cancer, especially due to high false positive rates, insufficient sensitivity, and operational complexity.
A hierarchical anchoring probe system was designed, which pre-fixed and standardized the probe through a functionalized nuclear pore membrane sensor. Combined with electrochemical detection, a "capture-anchoring-blocking" functional chain was formed to ensure the specific binding of the probe to the target and signal amplification.
It achieves high specificity, sensitivity and stability in the detection of Septin9 gene methylation, reduces the false positive rate, simplifies the operation process, and is suitable for the ultra-early diagnosis of colorectal cancer.
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Figure CN121852545B_ABST