Ophiopogon powder for improving mitochondrial activity and anti-aging, and preparation method and application thereof

Ophiopogon japonicus powder was prepared by fermentation and enzymatic hydrolysis of Bacillus coagulans, which solved the problem of low dissolution rate of active ingredients in Ophiopogon japonicus. This method effectively enhances mitochondrial activity and has anti-aging effects, making it suitable for pharmaceuticals and skincare products. It is safe and biocompatible.

CN121868411BActive Publication Date: 2026-07-21FOSHAN GOLDEN HEALTH TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FOSHAN GOLDEN HEALTH TECH CO LTD
Filing Date
2026-03-18
Publication Date
2026-07-21

AI Technical Summary

Technical Problem

Existing technologies are unable to effectively break through the pectin-like mucilage barrier of Ophiopogon japonicus, resulting in low dissolution rate and low bioavailability of active ingredients, making it difficult to meet the needs of enhancing mitochondrial activity and anti-aging. Furthermore, chemically synthesized drugs pose risks of liver and kidney toxicity.

Method used

Ophiopogon japonicus powder was prepared by fermentation with Bacillus coagulans combined with a cascade reaction of pectin lyase and β-glucanase. By disrupting the cell structure of Ophiopogon japonicus, the dissolution rate and targeting effect of active ingredients were improved.

Benefits of technology

It significantly enhances the mitochondrial activity and anti-aging function of Ophiopogon japonicus powder, increases mitochondrial membrane potential, promotes ATP production, and reduces ROS levels. It has good safety and biocompatibility, making it suitable for pharmaceuticals and skincare products, and significantly improves cellular energy metabolism and skin health.

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Abstract

The application discloses a radix ophiopogonis powder for improving mitochondrial activity and anti-aging, a preparation method and application thereof, and relates to the technical field of radix ophiopogonis products. The radix ophiopogonis powder is prepared by taking fermented radix ophiopogonis coarse powder of Bacillus coagulans as a core, and then adopting pectolyase and beta-glucanase for enzymolysis. The prepared radix ophiopogonis powder can effectively improve mitochondrial membrane potential, activate mitochondrial complex I, increase ATP generation and reduce ROS level. In a zebra fish myocardial injury model, the output of heart beat is significantly recovered, and mitochondrial activation across models is realized. In a nematode model, the activity of nematode complex I, the movement ability of nematodes and the life span of nematodes can be significantly increased. Meanwhile, the radix ophiopogonis powder has good safety in human bodies, can improve mitochondrial activity and delay telomere shortening after oral administration. When used on human skin, the radix ophiopogonis powder has excellent moisturizing, barrier repair and antioxidant effects. The application has the functions of significantly improving mitochondrial activity and anti-aging.
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