An injectable self-healing hydrogel for treating radiation-induced oral ulcers and preparation method and application thereof

CN121868566BActive Publication Date: 2026-06-09SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Filing Date
2026-03-18
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing technologies are unable to effectively address the complex pathological process of radiation-induced oral ulcers, and lack treatment methods that simultaneously possess antibacterial, antioxidant, cell migration-promoting, and oral anatomical adaptation properties, resulting in prolonged wound healing.

Method used

By integrating carbon dots with migration-promoting functions and epigallocatechin gallate (EGCG) with excellent antioxidant capabilities into an injectable self-healing hydrogel, a stable three-dimensional network structure is constructed through dynamic Schiff base reaction and hydrogen bonding cross-linking, achieving broad-spectrum antibacterial activity, efficient ROS scavenging, and promotion of tissue regeneration.

Benefits of technology

This hydrogel exhibits excellent injectability, self-healing properties, broad-spectrum antibacterial activity, and high-efficiency antioxidant activity. It significantly promotes the healing of radiation-induced oral ulcers, enhances cell migration ability, alleviates oxidative stress, provides physical barrier intervention, and achieves rapid wound repair.

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Abstract

This application relates to the field of biomedical materials, disclosing an injectable self-healing hydrogel for treating radiation-induced oral ulcers, its preparation method, and its applications. The hydrogel in this application is an OCC / CDots / EGCG composite hydrogel, which uses an OCC-based hydrogel as a carrier and loads Vc-PEI-CDots with EGCG through a specific process. This composite hydrogel is injectable, possesses strong antibacterial and in vitro antioxidant capabilities, and exhibits significant healing-promoting functions. Animal experiments show that this hydrogel can effectively promote the healing of RIOM wounds, manifested in the restoration of epithelial continuity, reduced cell apoptosis, and upregulation of the expression of the tissue-promoting migration protein VIM and the key antioxidant enzyme GPX3, providing a novel and highly efficient biomedical material option for the treatment of clinical radiation-induced oral ulcerative mucositis.
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