A qi-replenishing and blood-nourishing cream as well as a preparation method and application thereof

Abstract

This application belongs to the field of traditional Chinese medicine technology, specifically relating to a Qi-tonifying and blood-nourishing paste, its preparation method, and its application. The raw materials for the Qi-tonifying and blood-nourishing paste include preparation A, preparation B, donkey-hide gelatin, and deer antler gelatin. Preparation A consists of the following raw materials: Astragalus membranaceus, stir-fried Atractylodes macrocephala, Poria cocos, Ligusticum chuanxiong, Angelica sinensis, Rehmannia glutinosa (raw and processed), Ziziphus jujuba var. spinosa (processed), Citrus reticulata peel (stir-fried), Platycladus orientalis seed, Lycium barbarum, and Glycyrrhiza uralensis (processed). Preparation B consists of the following raw materials: stir-fried Coix lacryma-jobi, Codonopsis pilosula, Paeonia lactiflora, Dioscorea opposita (raw), Triticum aestivum, Salvia miltiorrhiza, Dendrobium nobile, and Achyranthes bidentata. This invention discloses a traditional Chinese medicine paste for tonifying Qi and blood, and nourishing the liver and kidneys, overcoming the problems of poor taste, inconvenient administration, and unstable absorption of effective components in existing traditional Chinese medicine formulas for treating various symptoms caused by Qi and blood deficiency and liver and kidney insufficiency. Furthermore, this invention improves the traditional decoction into a paste, which has the advantages of better taste, portability, and ease of administration, significantly enhancing the synergistic effect of tonifying Qi and blood, and nourishing the liver and kidneys.

Description

Technical Field

[0001] This application belongs to the field of traditional Chinese medicine technology, specifically relating to a qi-tonifying and blood-nourishing paste, its preparation method, and its application. Background Technology

[0002] Cancer cachexia is a complex metabolic syndrome defined as progressive weight loss characterized by persistent skeletal muscle loss (with or without adipose tissue loss) that cannot be completely reversed by nutritional support alone. This wasting state is a common symptom accompanying the progression of malignant tumors to the middle and late stages. Its core mechanism lies in the complex interaction between tumor cells and the host, leading to systemic inflammatory response, negative nitrogen balance, and abnormal protein and lipid metabolism. Cachexia not only directly causes malnutrition, severe emaciation, and fatigue in patients, but also significantly affects their tolerance to radiotherapy and chemotherapy, quality of life, and survival prognosis. Western medicine currently mainly adopts multimodal interventions, including nutritional support, exercise rehabilitation, and the use of appetite stimulants and metabolic regulators. However, due to its complex inflammatory driving mechanism, the effects of Western medicine intervention alone are often limited, and more effective treatment strategies are urgently needed.

[0003] In Traditional Chinese Medicine (TCM) theory, cachexia and malnutrition accompanied by emaciation in malignant tumors often fall under the categories of "asthenia" and "abdominal masses," with the core pathogenesis lying in the deficiency of vital energy (weak spleen and stomach, insufficient production of qi and blood) and the accumulation of pathogenic factors (phlegm, blood stasis, and toxins obstructing the body). The advantage of TCM treatment lies in its holistic approach, not simply targeting weight loss but focusing on strengthening the body's resistance and consolidating its foundation. Clinically, methods such as invigorating the spleen and replenishing qi, warming the kidneys and assisting yang, harmonizing the stomach and suppressing nausea, and promoting blood circulation and removing blood stasis are commonly used, emphasizing starting with the spleen and stomach to restore the patient's digestive and absorptive functions, thereby improving appetite, increasing food intake, and alleviating gastrointestinal reactions such as nausea and vomiting caused by tumor treatment. Currently, TCM in the management of cancer cachexia is used as an important adjunct and supportive therapy, often in combination with Western nutritional support. Clinical studies have shown that standardized TCM intervention can effectively improve patients' weight and strength, improve inflammatory markers, and improve quality of life, providing an important synergistic solution for improving treatment adherence and survival benefits in cancer patients. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a qi-tonifying and blood-nourishing paste, its preparation method, and its application. Specifically, the following technical solution is adopted: In a first aspect, the present invention provides a Qi-tonifying and blood-nourishing paste, wherein the raw materials of the Qi-tonifying and blood-nourishing paste are composed of preparation A, preparation B, donkey-hide gelatin and deer antler gelatin; the ratio of preparation A, preparation B, donkey-hide gelatin and deer antler gelatin is 1 dose: 1 dose: 3-7 grams: 3-7 grams; Preparation A, by weight, consists of the following ingredients: 8-15g of Astragalus membranaceus, 3-7g of stir-fried Atractylodes macrocephala, 3-7g of Poria cocos, 3-7g of Ligusticum chuanxiong, 3-7g of Angelica sinensis, 3-7g of Rehmannia glutinosa (raw), 8-15g of Rehmannia glutinosa (processed), 3-7g of Ziziphus jujuba var. spinosa (sour jujube peel), 3-7g of stir-fried Citrus reticulata var. tangerine peel, 3-7g of Platycladus orientalis seed, 3-7g of Lycium barbarum, and 10-20g of prepared Glycyrrhiza uralensis. Preparation B, by weight, consists of the following ingredients: 8-15g of stir-fried coix seed, 3-7g of codonopsis, 3-7g of white peony root, 3-7g of raw Chinese yam, 8-15g of floating wheat, 4-8g of salvia miltiorrhiza, 3-7g of dendrobium, and 3-7g of achyranthes bidentata.

[0005] The core advantage of this Qi-tonifying and Blood-nourishing Paste for treating tumor cachexia lies in its innovative formula of "simultaneous tonification of the spleen and kidneys, and simultaneous regulation of Qi, blood, and essence," targeting the core pathogenesis of "Qi depletion and essence exhaustion, and dysfunction of the Triple Burner" in advanced cancer. It rebuilds the function of the middle burner through a combination of Astragalus membranaceus, Codonopsis pilosula, and stir-fried Atractylodes macrocephala (Astragalus membranaceus warms Yang without causing dryness, resolving Qi deficiency syndrome in tumors), replenishes the foundation of essence and blood with deer antler glue, donkey-hide gelatin, and Rehmannia glutinosa (the two glues enhance plasma protein synthesis), and overcomes the "inability to tolerate tonification" dilemma with stir-fried Coix lacryma-jobi and stir-fried Citrus reticulata peel. Furthermore, it innovatively combines Angelica sinensis, Ligusticum chuanxiong, and Salvia miltiorrhiza to activate bone marrow hematopoiesis, Triticum aestivum and Dendrobium nobile to regulate muscle metabolic balance, and Achyranthes bidentata to guide the medicine downwards and repair lower limb atrophy. The Qi-tonifying and Blood-nourishing paste provided by this invention provides simultaneous intervention at the molecular level for various components: nutritional metabolic disorders, chronic inflammatory storms, and cachexia mechanisms caused by abnormal energy consumption. It achieves high-density nutrient delivery through the paste dosage form, breaking through the limitations of modern nutritional support therapy that focuses on calories but neglects metabolism, and providing an integrated solution for patients with advanced cancer that combines life maintenance and quality of life.

[0006] As a further preferred embodiment, the ratio of preparation A, preparation B, donkey-hide gelatin, and deer antler gelatin is 1 dose: 1 dose: 4-6 grams: 4-6 grams; Preparation A, by weight, consists of the following ingredients: 8-12g of Astragalus membranaceus, 4-6g of stir-fried Atractylodes macrocephala, 4-6g of Poria cocos, 4-6g of Ligusticum chuanxiong, 4-6g of Angelica sinensis, 4-6g of Rehmannia glutinosa (raw), 8-12g of Rehmannia glutinosa (processed), 4-6g of Ziziphus jujuba var. spinosa (sour jujube peel), 4-6g of stir-fried Citrus reticulata var. tangerine peel, 4-6g of Platycladus orientalis seed, 4-6g of Lycium barbarum fruit, and 14-16g of prepared Glycyrrhiza uralensis. Preparation B, by weight, consists of the following ingredients: 8-12g of stir-fried coix seed, 4-6g of codonopsis, 4-6g of white peony root, 4-6g of raw Chinese yam, 8-12g of floating wheat, 5-7g of salvia miltiorrhiza, 4-6g of dendrobium, and 4-6g of achyranthes bidentata.

[0007] As a further preferred embodiment, the ratio of preparation A, preparation B, donkey-hide gelatin, and deer antler gelatin is 1 dose: 1 dose: 5 grams: 5 grams; Preparation A, by weight, consists of the following ingredients: 10g Astragalus membranaceus, 5g stir-fried Atractylodes macrocephala, 5g Poria cocos, 5g Ligusticum chuanxiong, 5g Angelica sinensis, 5g Rehmannia glutinosa (raw), 8g Rehmannia glutinosa (processed), 5g Ziziphus jujuba var. spinosa (stir-fried), 5g Citrus reticulata (stir-fried), 5g Platycladus orientalis (seed), 5g Lycium barbarum (fruit), and 15g Glycyrrhiza uralensis (processed). Preparation B, by weight, consists of the following ingredients: 10g of stir-fried coix seed, 5g of codonopsis, 5g of white peony root, 5g of raw Chinese yam, 10g of floating wheat, 6g of salvia miltiorrhiza, 5g of dendrobium, and 5g of achyranthes bidentata.

[0008] Secondly, the present invention provides a method for preparing the above-mentioned Qi-tonifying and blood-nourishing paste, comprising the following steps: Weigh each raw material according to the stated weight, combine preparation A and preparation B, add water and decoct for 1.5-2 hours, cool, filter, and obtain the first filtrate and filter residue; The filter residue was further boiled in water for 1.5-2 hours, cooled, and filtered to obtain the second filtrate. The first and second filtrates are combined and concentrated. Donkey-hide gelatin and deer antler gelatin are added and melted. The mixture is then simmered over low heat to obtain the Qi-tonifying and blood-nourishing paste.

[0009] Thirdly, the present invention provides the application of the above-mentioned Qi-tonifying and blood-nourishing paste in the preparation of a medicine for treating malnutrition accompanied by emaciation.

[0010] As a further preferred embodiment, the malnutrition accompanied by emaciation is caused by cachexia due to malignant tumors.

[0011] Fourthly, the present invention provides a medicine for clinical use in cases of malnutrition and emaciation caused by cachexia due to malignant tumors, wherein the medicine is the above-mentioned Qi-tonifying and blood-nourishing paste.

[0012] As a further preferred embodiment, the drug also includes pharmaceutically acceptable excipients.

[0013] As a further preferred embodiment, the excipients include fillers, diluents, wetting agents, and adhesives.

[0014] As a further preferred embodiment, the dosage form of the drug includes capsules, pills, granules, tablets, or oral liquids.

[0015] The beneficial effects of this invention are as follows: (1) This invention discloses a traditional Chinese medicine ointment that invigorates qi and nourishes blood, and tonifies the liver and kidneys. It overcomes the problems of poor taste, inconvenient administration, and unstable absorption of active ingredients in existing traditional Chinese medicine prescriptions for treating various symptoms caused by deficiency of both qi and blood and insufficiency of the liver and kidneys. (2) This invention improves the traditional decoction into a paste, which has the advantages of good taste, easy to carry and take. Furthermore, through specific formulation and preparation process, the effective ingredients of the medicine are more easily absorbed, significantly enhancing the synergistic effect of invigorating qi and nourishing blood, and tonifying the liver and kidneys. Detailed Implementation

[0016] The technical solutions of this application will be clearly and completely described below with reference to various embodiments. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0017] Example 1 A qi-tonifying and blood-nourishing paste, which is composed of preparation A, preparation B, 5 grams of donkey-hide gelatin and 5 grams of deer antler gelatin; Preparation A consists of 10g of Astragalus membranaceus, 5g of stir-fried Atractylodes macrocephala, 5g of Poria cocos, 5g of Ligusticum chuanxiong, 5g of Angelica sinensis, 5g of Rehmannia glutinosa, 8g of Rehmannia glutinosa (processed), 5g of Ziziphus jujuba var. spinosa, 5g of stir-fried Citrus reticulata var. tangerine peel, 5g of Platycladus orientalis seed, 5g of Lycium barbarum, and 15g of prepared Glycyrrhiza uralensis. Preparation B consists of 10g of stir-fried coix seed, 5g of codonopsis, 5g of white peony root, 5g of raw Chinese yam, 10g of floating wheat, 6g of salvia miltiorrhiza, 5g of dendrobium, and 5g of achyranthes bidentata.

[0018] Example 2 A method for preparing a qi-tonifying and blood-nourishing paste, the method comprising the following steps: (1) Weigh each raw material according to the weight of Example 1, combine preparation A and preparation B, add 1.5L of water and decoct for 2 hours, cool, filter, and obtain the first filtrate and filter residue; (2) Add 1.5L of water to the filter residue and boil for 2 hours. Cool and filter to obtain the second filtrate. (3) Combine the first and second filtrates and concentrate them. Add 5 grams of donkey-hide gelatin and 5 grams of deer antler gelatin to melt them. Simmer over low heat to make a paste. After cooling, divide it into 30 equal portions, seal them in plastic, and store them at 2-3℃ to obtain the Qi-tonifying and blood-nourishing paste.

[0019] Example 3 The Qi-tonifying and Blood-nourishing paste prepared in Example 2 was used for clinical testing, as detailed below: Relevant Clinical Case (I) (1) Basic Information Name: Li Moumou Gender: Male Age: 65 years old Date of visit: September 5, 2025 Follow-up appointment date: September 21, 2025 (2) Initial diagnosis The patient presented with a 6-month history of advanced lung cancer with bone metastasis, a 3-month history of progressive weight loss, fatigue, and poor appetite, which had worsened over the past week. Present illness: Six months ago, the patient presented to a city hospital with persistent cough and hemoptysis. A chest CT scan and biopsy confirmed stage IV lung adenocarcinoma with right rib metastasis. Targeted therapy (specific drugs unknown) was administered for two cycles, but was discontinued due to adverse reactions. Over the past three months, the patient has experienced persistent weight loss, dropping from 68 kg to 52 kg, accompanied by general weakness requiring a cane for daily walking and shortness of breath after climbing two flights of stairs. Appetite has significantly decreased, with a daily intake of approximately 100g, significant abdominal distension after meals, and occasional nausea. The patient experiences difficulty falling asleep at night, frequent awakenings, and difficulty falling back asleep, resulting in less than 3 hours of sleep per night. The patient also presents with pale complexion, pale lips and nails, numbness in the hands and feet, loose stools 2-3 times daily, and clear, copious urine. One week ago, the patient's symptoms worsened after catching a cold, with palpitations and dizziness occurring after exertion. There was no fever or hemoptysis. The patient came to the hospital seeking treatment from a traditional Chinese medicine practitioner. The patient has a 5-year history of hypertension, which is well controlled (130-140 / 80-90 mmHg). There is no history of diabetes, coronary heart disease, or drug allergies.

[0020] (3) Four diagnostic methods Visual examination: The patient is alert but lethargic, with a pale complexion, thin physique, and dry, loose skin; the tongue is pale and swollen with teeth marks on the edges, a thin, white, and moist coating, and the tongue is not very flexible.

[0021] Auscultation: The voice is weak and the breathing is short.

[0022] Medical history: Night sweats occur frequently, which stop upon waking. Hands and feet are cold, and there is soreness and weakness in the lower back and knees. There is no bitter taste in the mouth or dry throat. Appetite is poor. Stools are loose. Urine is clear and copious. Nocturia occurs 2-3 times.

[0023] Palpation: The pulse is deep, thready, and weak; the pulses at the cun, guan, and chi positions are all weak and do not respond to pressure.

[0024] (4) Traditional Chinese Medicine diagnosis General debility (deficiency of both qi and blood, and deficiency of spleen and kidney) (5) Western medicine diagnosis 1. Late-stage (Stage IV) lung adenocarcinoma with bone metastasis (cachexia stage) 2. Severe malnutrition 3. Mild anemia 4. Grade 1 hypertension (very high risk) Treatment: Replenish Qi and nourish blood, strengthen the spleen and benefit the kidneys Prescription: 10g Astragalus membranaceus, 5g stir-fried Atractylodes macrocephala, 5g Poria cocos, 5g Ligusticum chuanxiong, 5g Angelica sinensis, 5g Rehmannia glutinosa (raw), 8g Rehmannia glutinosa (prepared), 5g Ziziphus jujuba var. spinosa (stir-fried), 5g Citrus reticulata (stir-fried), 5g Platycladus orientalis seed, 5g Lycium barbarum, 15g prepared Glycyrrhiza uralensis, 10g stir-fried Coix lacryma-jobi, 5g Codonopsis pilosula, 5g Paeonia lactiflora, 5g Dioscorea opposita (raw), 10g Triticum aestivum, 6g Salvia miltiorrhiza, 5g Dendrobium nobile, 5g Achyranthes bidentata, 5g Colla corii asini, 5g Cervi cornu colla.

[0025] Usage: The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. During this period, keep warm, avoid fatigue, eat small, frequent meals, and supplement with appropriate amounts of high-quality protein (such as egg custard or minced lean meat).

[0026] (6) Follow-up visit (15 days after taking the medication) Chief complaint: Weight gain compared to before, and significant relief from symptoms such as fatigue, poor appetite, and insomnia.

[0027] Symptom improvement during consultation: Persistent weight gain, from 52kg to 55kg; significant reduction in general weakness; able to walk 500 meters independently; shortness of breath relieved after climbing two flights of stairs; significantly improved appetite, with daily food intake increasing to approximately 250g; reduced abdominal distension after meals; no nausea; shorter sleep duration at night, able to sleep continuously for 5-6 hours; relief from frequent dreams and easy awakening; improved complexion; improved pale lips and nails; reduced numbness in hands and feet; night sweats almost completely disappeared; relief from palpitations and dizziness after activity; stools changed to formed, soft stools, once daily; clear and copious urination; nocturia reduced to once; reduced lower back and knee weakness; able to independently perform daily activities such as dressing and washing.

[0028] Evaluation of efficacy after medication: After taking the medication, all symptoms improved significantly, the deficiency of both qi and blood was replenished, the deficiency of spleen and kidney was improved, and the patient's nutritional status and quality of life were significantly improved, demonstrating significant efficacy. It is recommended to continue taking the original prescription for 15 days, during which time blood routine and serum albumin should be monitored regularly, and follow-up medical attention should be sought if any discomfort occurs.

[0029] Relevant Clinical Case (II) (1) Basic Information Name: Wang Moumou Gender: Female Age: 52 years old Date of visit: October 12, 2025 Follow-up appointment date: October 28, 2025 (2) Initial diagnosis Chief complaint: Diagnosed with advanced breast cancer with lung metastasis 8 months ago, progressive weight loss and fatigue for 6 weeks, worsening for 3 days. Present Illness: Eight months ago, the patient presented to a local hospital with a painful lump in her right breast. Breast ultrasound, mammography, and biopsy confirmed invasive ductal carcinoma of the right breast (HER-2 negative, HR positive), with multiple lung metastases. She received four cycles of endocrine therapy (letrozole) combined with chemotherapy (docetaxel). Following chemotherapy, she experienced severe gastrointestinal reactions, including persistent nausea and vomiting. Her weight dropped from 55 kg to 43 kg in the past six weeks. She also experienced general weakness, requiring assistance to stand up after prolonged sitting, and was unable to perform daily household chores. Her appetite was extremely poor, consuming only a small amount of liquid food (approximately 150 ml) daily, followed by abdominal distension and belching. She suffered from severe insomnia, requiring sleep aids (estazolam) to fall asleep for 2-3 hours, and experiencing vivid dreams and frequent awakenings. She also presented with a sallow complexion, pale lips and nails, significant hair loss, hot palms and soles, dry mouth and throat, constipation (once every 3-4 days), and scanty urination. Three days ago, the patient's symptoms worsened after emotional fluctuations, including dizziness, blurred vision, chest tightness, and palpitations after activity. She had no fever or chest pain and came to the hospital seeking traditional Chinese medicine treatment. She has a history of good health, no chronic illnesses, no drug allergies, and has been menopausal for 5 years.

[0030] (3) Four diagnostic methods Inspection: The patient is alert but lethargic, thin, with dry and scaly skin. Postoperative scars are visible on the right breast (right breast mass excision was performed 6 months ago). The tongue is pale, thin, with little and dry coating, and cracks at the tip.

[0031] Auscultation: The voice was low and the breathing was slightly rapid, with no unusual odor.

[0032] Medical history: In addition to the above symptoms, the patient complained of night sweats, with clothes soaked after waking up, irritability, soreness and weakness in the lower back and knees, dry mouth but no desire to drink, poor appetite, constipation, and scanty urination.

[0033] Palpation: The pulse is thready, rapid, and weak, especially the cun pulse.

[0034] (4) Traditional Chinese Medicine diagnosis General debility (deficiency of qi and blood, and deficiency of liver and kidney yin) (5) Western medicine diagnosis 1. Advanced stage IV invasive ductal carcinoma of the right breast with lung metastasis (cachexia stage) 2. Severe malnutrition 3. Moderate anemia (speculated, pending confirmation by complete blood count) 4. Drug-related insomnia Treatment: Replenish Qi and blood, nourish the liver and kidneys, moisten the intestines and calm the mind. Prescription: 10g Astragalus membranaceus, 5g stir-fried Atractylodes macrocephala, 5g Poria cocos, 5g Ligusticum chuanxiong, 5g Angelica sinensis, 5g Rehmannia glutinosa (raw), 8g Rehmannia glutinosa (prepared), 5g Ziziphus jujuba var. spinosa (stir-fried), 5g Citrus reticulata (stir-fried), 5g Platycladus orientalis seed, 5g Lycium barbarum, 15g prepared Glycyrrhiza uralensis, 10g stir-fried Coix lacryma-jobi, 5g Codonopsis pilosula, 5g Paeonia lactiflora, 5g Dioscorea opposita (raw), 10g Triticum aestivum, 6g Salvia miltiorrhiza, 5g Dendrobium nobile, 5g Achyranthes bidentata, 5g Colla corii asini, 5g Cervi cornu colla.

[0035] Usage: The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. During this period, keep warm, avoid fatigue, eat small, frequent meals, and supplement with appropriate amounts of high-quality protein (such as egg custard or minced lean meat).

[0036] (6) Follow-up visit (15 days after taking the medication) Chief complaint: Weight gain, with significant relief of symptoms such as fatigue, loss of appetite, and insomnia.

[0037] The patient reported improvements in symptoms, a 3kg weight gain to 46kg, significant reduction in general weakness, the ability to stand up independently and walk slowly for 300 meters, and the ability to perform simple household chores (such as folding clothes); a marked improvement in appetite, with the patient able to consume approximately 100g of staple food (rice / noodles) daily, along with vegetables and eggs, and reduced abdominal bloating and belching after meals; improved sleep quality, with the patient able to fall asleep for 4-5 hours without the need for sleep aids, and reduced vivid dreams and frequent awakenings; a rosier complexion, reduced pale lips and nails, slower hair loss, reduced hot flashes in the palms and soles, and improved dry mouth and throat; significantly reduced night sweats, with only slight sweating, reduced irritability, and reduced lower back and knee pain; bowel movements now occur once daily with a soft consistency, urine output has returned to normal, and dizziness, blurred vision, chest tightness, and palpitations after activity have largely disappeared.

[0038] Evaluation of efficacy after medication: After taking the medication, the patient's Qi and blood were replenished, and the deficiency of liver and kidney Yin gradually recovered. The patient's nutritional status, physical symptoms, and mental state all improved significantly, resulting in an enhanced quality of life. The efficacy is definite. It is recommended to continue taking the original prescription for 15 days, during which time blood routine and serum albumin should be checked again to observe changes in indicators. If any discomfort occurs (such as abdominal distension or diarrhea), seek medical attention promptly.

[0039] Relevant Clinical Case (III) (1) Basic Information Name: Zhao Moumou Gender: Male Age: 60 years old Date of visit: November 3, 2025 Follow-up appointment date: November 19, 2025 (2) Initial diagnosis Chief complaint: Diagnosed with advanced colorectal cancer with liver metastasis 7 months ago, progressive weight loss, fatigue and poor appetite for 2 months, which have worsened in the last 5 days. Present Illness: Seven months ago, the patient presented to another hospital with hematochezia and abdominal pain. Colonoscopy and pathological examination confirmed sigmoid colon cancer (moderately differentiated adenocarcinoma). An enhanced abdominal CT scan revealed multiple metastatic lesions in the right lobe of the liver. The patient received 5 cycles of chemotherapy (capecitabine combined with oxaliplatin). Following chemotherapy, the patient developed persistent diarrhea and decreased appetite, with weight dropping from 63 kg to 48 kg in the past two months. This was accompanied by general weakness; standing for more than 10 minutes resulted in lower limb weakness requiring rest, making independent outings impossible. Appetite was severely reduced, with daily food intake less than 100g, primarily consisting of liquids. Significant abdominal distension occurred after meals, with occasional nausea. The patient experienced difficulty falling asleep at night, tossing and turning for 1-2 hours before finally falling asleep, and was easily awakened, finding it difficult to fall back asleep. Daily sleep was only 2-3 hours. The patient also experienced pallor, pale lips and nails, dizziness, palpitations and shortness of breath after exertion, cold hands and feet, and loose stools (3-4 times daily). Occasionally, there is undigested food residue), and the urine is clear and copious. Five days ago, the symptoms worsened due to improper diet (eating a small amount of greasy food), with abdominal pain and increased bowel movements (5 times a day), but no rectal bleeding or fever. The patient came to the hospital seeking traditional Chinese medicine treatment. The patient has a 10-year history of chronic enteritis, but no history of hypertension, diabetes, or other chronic diseases, and no history of drug allergies.

[0040] (3) Four diagnostic methods Visual examination: The patient is alert but lethargic, thin, with loose and inelastic skin, and a slightly distended abdomen; the tongue is pale and swollen with obvious teeth marks on the edges, a white and greasy coating, and a slippery surface.

[0041] Auscultation: The patient's voice was weak and short of breath. Abdominal auscultation revealed active bowel sounds with no unusual odor.

[0042] Medical history: In addition to the above symptoms, the patient complained of soreness and weakness in the lower back and knees, aversion to cold, night sweats (small amount), dry mouth but no desire to drink, poor appetite, abdominal distension after meals, loose stools, clear and copious urine, and urination twice at night.

[0043] Palpation: The pulse is deep, slow, and weak, especially the Guan pulse, which feels like a thread when pressed.

[0044] (4) Traditional Chinese Medicine diagnosis General debility (deficiency of both qi and blood, and deficiency of spleen and kidney yang) (5) Western medicine diagnosis 1. Stage IV sigmoid colon cancer with liver metastasis (cachexia stage) 2. Severe malnutrition 3. Moderate anemia (to be confirmed by complete blood count) 4. Chemotherapy-related bowel dysfunction Treatment: Tonify Qi and nourish blood, warm and tonify the spleen and kidneys, and strengthen the intestines to stop diarrhea. Prescription: 10g Astragalus membranaceus, 5g stir-fried Atractylodes macrocephala, 5g Poria cocos, 5g Ligusticum chuanxiong, 5g Angelica sinensis, 5g Rehmannia glutinosa (raw), 8g Rehmannia glutinosa (prepared), 5g Ziziphus jujuba var. spinosa (stir-fried), 5g Citrus reticulata (stir-fried), 5g Platycladus orientalis seed, 5g Lycium barbarum, 15g prepared Glycyrrhiza uralensis, 10g stir-fried Coix lacryma-jobi, 5g Codonopsis pilosula, 5g Paeonia lactiflora, 5g Dioscorea opposita (raw), 10g Triticum aestivum, 6g Salvia miltiorrhiza, 5g Dendrobium nobile, 5g Achyranthes bidentata, 5g Colla corii asini, 5g Cervi cornu colla.

[0045] Usage: The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. During this period, keep warm, avoid fatigue, eat small, frequent meals, and supplement with appropriate amounts of high-quality protein (such as egg custard or minced lean meat).

[0046] (6) Follow-up visit (15 days after taking the medication) Chief complaint: Weight gain, with significant relief of symptoms such as fatigue, loss of appetite, and diarrhea.

[0047] Symptom improvement during consultation: Weight increased by 2.5 kg to 50.5 kg; general weakness significantly relieved; able to stand independently for 30 minutes and walk slowly for 400 meters without frequent rest; appetite significantly improved; able to eat approximately 120g of staple food (steamed buns / rice) daily, supplemented with vegetables and minced lean meat; abdominal distension reduced after meals, no nausea; improved sleep at night; able to fall asleep within 30 minutes of lying down and sleep continuously for 5-6 hours with fewer awakenings; complexion rosier than before; purplish lips and nails alleviated; dizziness, palpitations, and shortness of breath after activity largely disappeared; cold hands and feet improved, hands and feet felt warm to the touch; bowel movements reduced to 1-2 times daily, with formed stools and no undigested food residue; lower back and knee pain, aversion to cold reduced; night sweats disappeared; dry mouth relieved; urination clear and copious, nocturia reduced to once. Only occasional mild abdominal distension after meals, which resolves spontaneously without special treatment. Pulse deep, slow, and strong; clear pulse at the Guan position, significantly improved compared to before.

[0048] Evaluation of efficacy after medication: After taking the medication, the patient's Qi and blood gradually replenished, the Yang Qi of the spleen and kidneys was restored, and intestinal dysfunction was relieved. The patient's nutritional status, physical symptoms, and ability to live independently all significantly improved, demonstrating significant efficacy. It is recommended to continue taking the original prescription for 15 days, during which time blood routine tests, serum albumin, and liver and kidney function tests should be repeated. Close monitoring of changes in the condition is necessary, and medical attention should be sought immediately if abnormalities such as abdominal pain or rectal bleeding occur.

[0049] Comparative Example 1 Patient basic information: Mr. Liu, 58 years old, late-stage pancreatic cancer. He had undergone chemotherapy, but it was discontinued due to severe side effects.

[0050] Chief complaint and medical history: Severe cachexia. Weight loss exceeding 20% ​​within 3 months, extreme emaciation (skin and bones), weakness, and bedridden status. Simultaneously, the patient presents with severe cancer pain (abdominal pain aggravated by pressure), a palpable hard mass in the abdomen, jaundice of the skin and sclera, dark yellow urine, bitter taste in the mouth, purplish-dark tongue with ecchymosis, thick yellow and greasy tongue coating, and a wiry, slippery, and rapid pulse. The patient's family hopes to "nourish the body and strengthen its resistance."

[0051] Treatment process: Prescription: 10g Astragalus membranaceus, 5g stir-fried Atractylodes macrocephala, 5g Poria cocos, 5g Angelica sinensis, 5g Rehmannia glutinosa (raw), 8g prepared Rehmannia glutinosa, 5g Ziziphus jujuba var. spinosa, 5g Platycladus orientalis seed, 5g Lycium barbarum, 15g prepared Glycyrrhiza uralensis, 10g stir-fried Coix lacryma-jobi, 5g Codonopsis pilosula, 5g Paeonia lactiflora, 5g Dioscorea opposita, 10g Triticum aestivum, 6g Salvia miltiorrhiza, 5g Dendrobium nobile, 5g Achyranthes bidentata, 5g donkey-hide gelatin, 5g deer antler gelatin. (Compared to the Qi-tonifying and Blood-nourishing Paste provided above in this invention, it lacks 5g stir-fried Citrus reticulata peel and 5g Ligusticum chuanxiong.) Usage: The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. During this period, keep warm, avoid fatigue, eat small, frequent meals, and supplement with appropriate amounts of high-quality protein (such as egg custard or minced lean meat).

[0052] After taking the medication, the patient experienced no improvement in appetite or strength; instead, abdominal distension worsened, nausea and vomiting increased, jaundice deepened, and pain seemed more pronounced. The medication had to be discontinued after one week.

[0053] Analysis of poor results: When using Qi-tonifying and blood-nourishing paste, the patient's spleen and stomach function should be considered. If the spleen and stomach function is insufficient and the digestive function is impaired, the nourishing medicine is difficult to digest. Therefore, stir-fried tangerine peel and chuanxiong are used to regulate Qi and dry dampness, rather than simply tonifying.

[0054] Comparative Example 2 Patient basic information: Ms. Wang, 72 years old, with advanced gastric cancer and extensive peritoneal metastasis. She is unable to eat and relies on intravenous nutrition.

[0055] Chief complaint and medical history: Cachexia. Extreme exhaustion, weak voice, dry skin. Key signs: Inability to swallow liquids, vomiting immediately after eating, cold and hard epigastric region (mass), regurgitation of clear fluid, loose stools, pale and swollen tongue with a slippery, watery coating, and a weak and thready pulse.

[0056] Treatment process: Prescription: 10g Astragalus membranaceus, 5g stir-fried Atractylodes macrocephala, 5g Ligusticum chuanxiong, 5g Angelica sinensis, 5g Rehmannia glutinosa (raw), 8g Rehmannia glutinosa (processed), 5g Ziziphus jujuba var. spinosa (processed), 5g Citrus reticulata (stir-fried), 5g Platycladus orientalis seed, 5g Lycium barbarum, 15g Glycyrrhiza uralensis (processed), 5g Codonopsis pilosula, 5g Paeonia lactiflora, 5g Dioscorea opposita (raw), 10g Triticum aestivum, 6g Salvia miltiorrhiza, 5g Dendrobium nobile, 5g Achyranthes bidentata, 5g Colla corii asini, 5g Cervi cornu colla. (Compared to the Qi-tonifying and Blood-nourishing Paste provided above in this invention, it lacks 10g stir-fried Coix lacryma-jobi and 5g Poria cocos.) Usage: The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. During this period, keep warm, avoid fatigue, eat small, frequent meals, and supplement with appropriate amounts of high-quality protein (such as egg custard or minced lean meat).

[0057] Each time the patient took the medication, it triggered severe vomiting, expelling both water and the medicine, making absorption impossible. An attempt was made to switch to nasal feeding of small amounts of diluted herbal paste, but the patient still experienced persistent diarrhea, and their condition deteriorated rapidly.

[0058] Analysis of poor efficacy: For patients with cachexia due to spleen deficiency and dampness, adding stir-fried coix seed and Chinese yam to the Qi-tonifying and blood-nourishing paste can enhance its dampness-removing effect.

[0059] Comparative Example 3 Patient basic information: Mr. Zhang, 50 years old, has advanced lung cancer and is currently receiving targeted therapy.

[0060] Chief complaint and medical history: Cachexia with significant wasting. The patient is emaciated but presents with hot flashes and night sweats (especially at night), hot flashes in the palms, soles, and chest, cough with little sputum but streaked with blood, dry mouth and throat with a desire for cold drinks, a dry, red tongue with no coating, and a thready, rapid pulse. Western medicine diagnosis includes "tumor hypermetabolic state" and side effects such as dry skin and paronychia caused by targeted therapy.

[0061] Treatment process: Prescription: 10g Astragalus membranaceus, 5g stir-fried Atractylodes macrocephala, 5g Poria cocos, 5g Ligusticum chuanxiong, 5g Angelica sinensis, 8g Rehmannia glutinosa, 5g Ziziphus jujuba peel, 5g stir-fried Citrus reticulata peel, 5g Platycladus orientalis seed, 5g Lycium barbarum, 15g prepared Glycyrrhiza uralensis, 10g stir-fried Coix lacryma-jobi, 5g Codonopsis pilosula, 5g Paeonia lactiflora, 5g raw Dioscorea opposita, 10g Triticum aestivum, 6g Salvia miltiorrhiza, 5g Achyranthes bidentata, 5g donkey-hide gelatin, 5g deer antler gelatin. (Compared to the Qi-tonifying and Blood-nourishing Paste provided above in this invention, it lacks 5g Dendrobium nobile and 5g Rehmannia glutinosa.) Usage: The above is a one-day dosage. Prepare two packets of the paste. Take one packet each time, twice daily, with warm water after breakfast and dinner. Continue for 15 days, then return for a follow-up appointment. During this period, keep warm, avoid fatigue, eat small, frequent meals, and supplement with appropriate amounts of high-quality protein (such as egg custard or minced lean meat).

[0062] After taking the medication, the patient experienced worsened hot flashes and night sweats, increased dry mouth, and even nosebleeds. Coughing and irritability also worsened. The dryness of the skin and mucous membranes caused by the targeted drug also deteriorated.

[0063] Analysis of poor results: The deficiency of yin and the excess of fire caused by "cancer toxins depleting yin fluids" are addressed by adding Rehmannia glutinosa and Dendrobium to this qi-tonifying and blood-nourishing paste to nourish the yin of the lungs and stomach, while also taking care of the yin fluids.

[0064] The technical solutions of the present invention have been described above in conjunction with various embodiments. Specific examples have been used to illustrate the principles and implementation methods of this application. The description of the above embodiments is only for the purpose of helping to understand the core ideas of this application. However, this application is not limited to the specific implementation methods described above. The specific implementation methods described above are merely illustrative and not restrictive. Those skilled in the art can make many other forms under the guidance of this application without departing from the spirit and scope of protection of the claims, and all of these forms are within the protection scope of this application.

Claims

1. A qi-tonifying and blood-nourishing paste, characterized in that, The ingredients of the Qi-tonifying and Blood-nourishing Paste are composed of preparation A, preparation B, donkey-hide gelatin, and deer antler gelatin; the ratio of preparation A, preparation B, donkey-hide gelatin, and deer antler gelatin is 1 dose: 1 dose: 3-7 grams: 3-7 grams; Preparation A, by weight, consists of the following ingredients: 8-15g of Astragalus membranaceus, 3-7g of stir-fried Atractylodes macrocephala, 3-7g of Poria cocos, 3-7g of Ligusticum chuanxiong, 3-7g of Angelica sinensis, 3-7g of Rehmannia glutinosa (raw), 8-15g of Rehmannia glutinosa (processed), 3-7g of Ziziphus jujuba var. spinosa (sour jujube peel), 3-7g of stir-fried Citrus reticulata var. tangerine peel, 3-7g of Platycladus orientalis seed, 3-7g of Lycium barbarum, and 10-20g of prepared Glycyrrhiza uralensis. Preparation B, by weight, consists of the following ingredients: 8-15g of stir-fried coix seed, 3-7g of codonopsis, 3-7g of white peony root, 3-7g of raw Chinese yam, 8-15g of floating wheat, 4-8g of salvia miltiorrhiza, 3-7g of dendrobium, and 3-7g of achyranthes bidentata.

2. The Qi-tonifying and Blood-nourishing Paste according to claim 1, characterized in that, The ratio of preparation A, preparation B, donkey-hide gelatin, and deer antler gelatin is 1 dose: 1 dose: 4-6 grams: 4-6 grams; Preparation A, by weight, consists of the following ingredients: 8-12g of Astragalus membranaceus, 4-6g of stir-fried Atractylodes macrocephala, 4-6g of Poria cocos, 4-6g of Ligusticum chuanxiong, 4-6g of Angelica sinensis, 4-6g of Rehmannia glutinosa (raw), 8-12g of Rehmannia glutinosa (processed), 4-6g of Ziziphus jujuba var. spinosa (sour jujube peel), 4-6g of stir-fried Citrus reticulata var. tangerine peel, 4-6g of Platycladus orientalis seed, 4-6g of Lycium barbarum fruit, and 14-16g of prepared Glycyrrhiza uralensis. Preparation B, by weight, consists of the following ingredients: 8-12g of stir-fried coix seed, 4-6g of codonopsis, 4-6g of white peony root, 4-6g of raw Chinese yam, 8-12g of floating wheat, 5-7g of salvia miltiorrhiza, 4-6g of dendrobium, and 4-6g of achyranthes bidentata.

3. The Qi-tonifying and Blood-nourishing Paste according to claim 1, characterized in that, The ratio of preparation A, preparation B, donkey-hide gelatin, and deer antler gelatin is 1 dose: 1 dose: 5 grams: 5 grams; Preparation A, by weight, consists of the following ingredients: 10g Astragalus membranaceus, 5g stir-fried Atractylodes macrocephala, 5g Poria cocos, 5g Ligusticum chuanxiong, 5g Angelica sinensis, 5g Rehmannia glutinosa (raw), 8g Rehmannia glutinosa (processed), 5g Ziziphus jujuba var. spinosa (stir-fried), 5g Citrus reticulata (stir-fried), 5g Platycladus orientalis (seed), 5g Lycium barbarum (fruit), and 15g Glycyrrhiza uralensis (processed). Preparation B, by weight, consists of the following ingredients: 10g of stir-fried coix seed, 5g of codonopsis, 5g of white peony root, 5g of raw Chinese yam, 10g of floating wheat, 6g of salvia miltiorrhiza, 5g of dendrobium, and 5g of achyranthes bidentata.

4. A method for preparing the Qi-tonifying and blood-nourishing paste according to any one of claims 1-3, characterized in that, Includes the following steps: Weigh each raw material according to the stated weight, combine preparation A and preparation B, add water and decoct for 1.5-2 hours, cool, filter, and obtain the first filtrate and filter residue; The filter residue was further boiled in water for 1.5-2 hours, cooled, and filtered to obtain the second filtrate. The first and second filtrates are combined and concentrated. Donkey-hide gelatin and deer antler gelatin are added and melted. The mixture is then simmered over low heat to obtain the Qi-tonifying and blood-nourishing paste.

5. The use of the Qi-tonifying and blood-nourishing paste according to any one of claims 1-3 in the preparation of a medicine for treating malnutrition accompanied by emaciation.

6. The application according to claim 5, characterized in that, The malnutrition accompanied by emaciation is caused by cachexia due to malignant tumors.

7. A drug used clinically for malnutrition and emaciation caused by cachexia due to malignant tumors, characterized in that, The medicine includes the Qi-tonifying and blood-nourishing paste according to any one of claims 1-3.

8. The medicament according to claim 7, characterized in that, The drug also includes pharmaceutically acceptable excipients.

9. The medicament according to claim 8, characterized in that, The excipients include fillers, diluents, humectants, and adhesives.

10. The medicament according to any one of claims 7-9, characterized in that, The dosage forms of the drug include capsules, pills, granules, tablets, or oral liquids.