一种长效生物粘附防渗漏的多层高分子聚合物复合贴片及制备方法

By using a cross-linked network design of a multi-layer polymer composite patch, the problem of easy adhesion failure of existing patches is solved, achieving long-lasting adhesion and high-strength sealing, which is suitable for rapid repair of complex wounds.

CN121891595BActive Publication Date: 2026-07-17ZHEJIANG UNIV

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Filing Date
2026-03-25
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing tissue repair patches are prone to adhesion failure in the moist environment of the body, and cannot achieve long-term adhesion. Furthermore, traditional suturing methods are not good at sealing complex soft tissue wounds, and there is a risk of secondary damage and infection.

Method used

The multi-layer polymer composite patch, including an anti-adhesion layer, an adhesive layer, another anti-adhesion layer, and a cross-linking layer, improves the cohesive strength and interfacial bonding of the material through a specific cross-linking network design, integrating high-strength self-adhesion, antibacterial properties, and biocompatibility.

Benefits of technology

It achieves long-lasting adhesion in humid environments, enhances interfacial adhesion strength, reduces the risk of leakage, and minimizes secondary damage and infection opportunities, making it suitable for rapid sealing and repair of complex wounds.

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Abstract

本发明公开了一种长效生物粘附防渗漏的多层高分子聚合物复合贴片及制备方法。该贴片包括依次设置的抗粘附层、粘附层、抗粘附层、交联层及含多个亚层的粘附层,本发明通过策略性地引入层间交联层并调控粘附层与交联层的配方,极大地增强了粘附层的高分子网络结构与层间的结合力,有效提升了其内聚强度(Cohesive Strength)与片材强度。通过这种交联增强,本贴片不仅在界面上(Interface)能与组织快速、牢固地复合粘合,更保证了粘附层材料自身具备足够的持久性,从而解决了传统贴片粘附力衰减快的行业痛点。本发明的贴片具有自粘性、高生物相容性,能提供长时间的贴合、连接、密封和防渗漏功能,特别适用于体内软组织伤口的辅助连接、密封、加固和长效愈合。
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