A method for the co-production of hydroxylamine hydrochloride from 2,4-dichloro-5-fluoroacetophenone

The one-pot reaction for co-producing 2,4-dichloro-5-fluoroacetophenone and hydroxylamine hydrochloride solves the problem of separate production in traditional processes, achieving high yield and safe and environmentally friendly production, simplifying the operation process and improving economic benefits.

CN121895131BActive Publication Date: 2026-06-30SHANDONG GUOBANG PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG GUOBANG PHARMA
Filing Date
2026-03-24
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

In the existing technology, the production of 2,4-dichloro-5-fluoroacetophenone and hydroxylamine hydrochloride are both separate processes, which fail to achieve efficient co-production. Furthermore, traditional processes have problems such as the use of hazardous reagents and complex procedures.

Method used

A one-pot reaction method is adopted, in which 2,4-dichlorofluorobenzene reacts with anhydrous aluminum chloride to produce 2,4-dichloro-5-fluoroethylbenzene, which then reacts with tert-butyl nitrite to produce oxime. Subsequently, hydrolysis with hydrochloric acid produces 2,4-dichloro-5-fluoroacetophenone and hydroxylamine hydrochloride, simplifying the operation process and avoiding the use of hazardous reagents.

Benefits of technology

High-yield production of 2,4-dichloro-5-fluoroacetophenone and hydroxylamine hydrochloride was achieved, improving atom economy and process safety, reducing production costs, and enhancing product market competitiveness.

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Abstract

This application discloses a method for the co-production of hydroxylamine hydrochloride from 2,4-dichloro-5-fluoroacetophenone, belonging to the field of organic chemical technology. Using 2,4-dichlorofluorobenzene as a raw material, the process involves alkylation, reaction with tert-butyl nitrite to generate an oxime, followed by hydrolysis with hydrochloric acid to produce 2,4-dichloro-5-fluoroacetophenone and hydroxylamine hydrochloride. This innovative method achieves the co-production of 2,4-dichloro-5-fluoroacetophenone and hydroxylamine hydrochloride, ensuring not only a high yield and high purity of the target product 2,4-dichloro-5-fluoroacetophenone, but also converting nitrogen in the reaction into high-value-added hydroxylamine hydrochloride, significantly improving atom economy. This method greatly simplifies the operation process, avoids the use of hazardous reagents, and improves the inherent safety and environmental friendliness of the process from the source. The method is simple to operate, safe, and environmentally friendly, effectively reducing production costs and enhancing the market competitiveness of the product.
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