一种脱细胞基质双网络水凝胶及其制备方法和应用
By using heparin-loaded decellularized matrix dual-network hydrogels with interpenetrating network structures and photocrosslinking technology, the problems of untunable mechanical properties and insufficient bioactivity of existing microcarriers have been solved. This enables precise control of the mechanical properties of the hydrogels and maintenance of their bioactivity, making them suitable for nerve tissue repair.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- EAST CHINA UNIV OF SCI & TECH
- Filing Date
- 2026-03-19
- Publication Date
- 2026-07-17
AI Technical Summary
Existing single decellularized matrix microcarriers have fixed and unadjustable mechanical properties, making it difficult to match the differentiated needs of different tissue repair stages, and also difficult to simultaneously retain bioactivity and simulate complex extracellular microenvironments.
A heparin-loaded decellularized matrix dual-network hydrogel was used, which formed an interpenetrating network structure by mixing (meth)acrylamide gelatin with the decellularized matrix. Combined with photocrosslinking and amidation reactions, the mechanical properties and bioactivity of the hydrogel were adjusted.
It achieves precise control over the mechanical properties of hydrogels, provides a neural-specific microenvironment, supports deep cell infiltration and long-term sustained release of heparin, and adapts to the dynamic needs of different tissue repair stages.
Smart Images
Figure CN121895598B_ABST