一种医用防水粘合剂及其制备方法和应用

A waterproof adhesive was prepared by adjusting the rheological properties through chemical crosslinking and hydrolysis, which solved the problem of easy dilution of liquid adhesives in moist surgical environments. This resulted in stable bonding and positioning in moist environments, providing a safe and efficient sutureless surgical solution.

CN121930482BActive Publication Date: 2026-07-17EYE HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY (SHANDONG EYE HOSPITAL)

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
EYE HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY (SHANDONG EYE HOSPITAL)
Filing Date
2026-03-30
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing liquid adhesives are easily diluted and difficult to position in moist surgical environments, leading to adhesion failure or complications, which limits their clinical translation and application in different liquid surgical scenarios.

Method used

Solid gels are prepared by chemical crosslinking, and their rheological properties are adjusted by hydrolysis to form a three-dimensional crosslinked network with amide bonds. Subsequently, a hydrophilic polymer network is formed under light irradiation to obtain a waterproof adhesive.

Benefits of technology

It achieves anti-dilution and positioning stability of the adhesive in humid environments, ensuring stable residence and precise positioning on the target tissue surface, and providing a safe and efficient sutureless adhesive and wound closure solution.

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Abstract

本发明提供了一种医用防水粘合剂及其制备方法和应用。医用防水粘合剂的制备方法包括先制备固态凝胶,再调节固态凝胶的流变性能,获得粘弹性流体状防水粘合剂。本发明提供的粘合胶制备方法操作简便、工艺可控、重复性高、成本低。制备得到的防水粘合胶性能稳定,在常温下表现出良好的可注射性与铺展性,便于手术操作;在湿润的眼表环境中,预先形成的网络能够有效抵抗泪液、房水及血液等体液的即时冲刷与稀释,确保其在目标组织表面稳定驻留与精准定位;在特定波长光源照射下,凝胶发生聚合反应,在湿润条件下迅速形成致密、牢固的二次交联网络,实现稳定可靠的原位固化与组织粘附。
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