Nicotinamide nucleotide transhydrogenase mutants and uses thereof

CN121931063BActive Publication Date: 2026-07-21TIANJIN HERUN BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN HERUN BIOTECHNOLOGY CO LTD
Filing Date
2026-03-30
Publication Date
2026-07-21

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Abstract

The application provides a nicotinamide nucleotide transhydrogenase mutant and application thereof, a valine at the 169th position of the nicotinamide nucleotide transhydrogenase mutant is mutated into isoleucine, and the mutant is used for constructing a lysine production strain. The new strain does not contain plasmid, has no growth defect, and does not need induction. The new strain has the advantages of good genetic stability, high fermentation yield and the like, and can efficiently and stably produce lysine from glucose as a substrate.
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