一种中药制药生产过程在线检测系统

By analyzing the heating temperature difference fluctuation sequence and the set of heat transfer pulse pairs, the problem of low concentration identification accuracy in the vacuum concentration process of traditional Chinese medicine was solved, enabling accurate estimation of the concentration of the medicinal liquid and accurate identification of the risk of wall adhesion, thus avoiding material coking.

CN121933567BActive Publication Date: 2026-07-17SHAANXI UNIV OF CHINESE MEDICINE

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHAANXI UNIV OF CHINESE MEDICINE
Filing Date
2026-03-31
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing online detection methods struggle to distinguish between actual concentration changes and overheating errors caused by rheological thermal resistance during the vacuum concentration of traditional Chinese medicine extracts. This leads to reduced accuracy in recognizing the concentration state, making it impossible to accurately identify the risk of adhesion to the walls, which in turn causes material coking.

Method used

By acquiring the difference fluctuations between the heater inlet temperature sequence and the main liquid temperature sequence of the concentration tank, the heating temperature difference fluctuation sequence is extracted, the pulse signal characteristics are analyzed, effective heat conduction is screened, the heat transfer pulse pair set is obtained, the stability broadening ratio and heat transfer resistance index are calculated, and the concentration boiling point value of the solute is retrieved by combining the measured temperature, so as to achieve accurate decision-making on the evaporation state.

Benefits of technology

It effectively eliminates temperature disturbances caused by bubble bursting and localized boiling, improves the accuracy of drug concentration identification, accurately identifies the risk of wall adhesion, and avoids material charring.

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Abstract

本发明涉及中药蒸发控制技术领域,具体涉及一种中药制药生产过程在线检测系统。该系统通过实时监测浓缩罐内加热器入口温度及药液主体温度,分析监测时刻下温度波动的形态与特征,提取加热脉冲集合与标准脉冲集合;基于热传导时间约束构建评估矩阵并求解全局最优匹配,筛选热传递脉冲对集合并计算脉冲展宽比率,合成传热阻力指数;进一步基于实测温度与传热阻力指数的偏差,反演溶质浓度沸点值。系统由此进行浓度达标与流变安全的双重阈值判定,实时决策蒸发状态与生产安全控制。本发明通过热动力学闭环调控,解决了高黏度工况下温度测量与真实浓度失配的问题,提高了中药浓缩终点检测的精准性与生产安全性。
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