一种促口腔溃疡愈合活性多肽及其应用
By using the active polypeptide NPTX3 from the venom glands of *Gnaphalium affine*, the side effects of existing oral ulcer treatments have been resolved. This approach promotes cell migration and tissue repair at extremely low doses, significantly improving ulcer healing rates and providing a highly efficient and safe new treatment option.
CN121949482BActive Publication Date: 2026-07-17YUNNAN MINZU UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- YUNNAN MINZU UNIV
- Filing Date
- 2026-04-02
- Publication Date
- 2026-07-17
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Figure CN121949482B_ABST
Abstract
本发明公开了一种促口腔溃疡愈合活性多肽及其应用，属于生物医药技术领域。促口腔溃疡愈合活性多肽NPTX3的氨基酸序列为:DLKPIAEDIPSLEK。体外实验结果显示，在低至500pM浓度下，多肽NPTX3即可显著促进人永生化角质形成细胞的划痕闭合。Transwell迁移实验进一步证实，其在1nM和10nM浓度下可明显增强HaCaT细胞的迁移能力，提示其可能通过促进上皮细胞迁移来加速创面修复。在SD大鼠口腔溃疡模型中，局部应用多肽NPTX3能够显著提高溃疡愈合率。本发明多肽NPTX3在极低剂量下即显示出卓越的促细胞迁移与组织修复活性，具有起效剂量低、生物活性强、安全性高等优势。
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