降解玉米赤霉烯酮的壳聚糖-组氨酸复合材料及其制备方法与应用

By preparing porous chitosan microspheres with three-dimensional interconnected channels and crosslinking with histidine, a chitosan-histidine composite material was constructed, achieving efficient degradation of zearalenone. This solves the problem that chitosan materials cannot be completely detoxified in existing technologies and provides an efficient and low-cost zearalenone removal solution.

CN121949903BActive Publication Date: 2026-07-17TIANJIN UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN UNIV OF SCI & TECH
Filing Date
2026-04-02
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In existing technologies, chitosan materials can only adsorb zearalenone and cannot achieve structural degradation and complete detoxification. Modified chitosan materials have low catalytic activity, poor stability, complex preparation processes, and high costs, making it difficult to achieve efficient, stable, and safe degradation in complex feed environments.

Method used

By preparing porous chitosan microspheres with three-dimensional interconnected channels and crosslinking histidine with genipin to construct a chitosan-histidine composite material, the catalytic mechanism of natural lactone hydrolase was simulated to achieve the hydrolytic cleavage of lactone bonds in ZEN.

Benefits of technology

Under optimized conditions, the composite material can achieve a degradation efficiency of over 37% for ZEN, exhibiting high efficiency, greenness, and low cost. It is suitable for the removal of zearalenone from food and feed, overcoming the difficulties in extraction and easy inactivation of natural enzymes.

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Abstract

本发明公开了一种降解玉米赤霉烯酮的壳聚糖‑组氨酸复合材料及其制备方法与应用,属于霉菌毒素脱除技术领域,所述壳聚糖‑组氨酸复合材料包括壳聚糖载体和通过京尼平交联于所述壳聚糖载体上的组氨酸,所述壳聚糖载体为含三维连通孔道结构的多孔壳聚糖微球。本发明的复合材料具有三维连通孔道显著增加了材料的比表面积,有利于活性位点的暴露;同时,大孔通道为疏水性底物ZEN提供了快速传质途径,有效促进了底物的富集与扩散,从而提升了整体催化效率。
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