A composition with qi and blood supplementing effect, and a pharmaceutical preparation and application thereof

Abstract

The present application relates to the technical field of traditional Chinese medicine, in particular to a composition with the function of qi and blood tonification, and a medicine preparation and application thereof. The raw materials of the composition consist of the following components in parts by weight: hesperetin 0.2-1 part, nobiletin 0.2-5 parts, lognside 0.05-0.2 parts, allantoin 0.1-1 part, glycyrrhizin 0.1-1 part, alnus ketone 0.1-1 part, rutin 0.02-0.2 part, apiosyl glycyrrhizin 0.2-2 parts and ammonium glycyrrhizinate 0.1-1 part. The present application combines each component, and the components are clear, simple, have the function of tonifying blood and qi, treating anemia and resisting fatigue.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a composition with the function of replenishing both qi and blood, its pharmaceutical preparation and application. Background Technology

[0002] Suboptimal health due to blood and qi deficiency is a common health problem plaguing modern people, with complex causes and wide-ranging effects. Anemia is mainly manifested as a lower-than-normal number of red blood cells or hemoglobin concentration in the blood, leading to insufficient oxygen supply to tissues and organs, which in turn causes a series of symptoms such as fatigue, dizziness, pale complexion, and palpitations.

[0003] Qi and blood deficiency falls under the category of Traditional Chinese Medicine (TCM) theory, referring to poor circulation or insufficient qi and blood in the body. Although it may not meet the diagnostic criteria for a disease, it can lead to a sub-healthy state characterized by fatigue, insomnia, and decreased immunity. The two are interconnected; insufficient qi and blood can exacerbate anemia symptoms, and anemia can also cause qi and blood circulation disorders.

[0004] Traditional Chinese medicine believes that qi and blood are the basic substances that constitute human life activities. The two are interdependent. Qi is the driving force of human activities, while blood is the nourishment and nutrient. Qi is the commander of blood, and blood is the mother of qi. "Qi and blood deficiency" refers to a state of qi deficiency and blood deficiency in the body. The basic functions of human physiological activities are weakened, resulting in poor bodily function and malnutrition. It is a disease caused by congenital deficiency, acquired malnutrition, or external damage to qi and blood.

[0005] Qi and blood deficiency is usually caused by qi deficiency leading to insufficient blood production or blood deficiency leading to insufficient qi production. Its formation mechanisms mainly include the following: Congenital deficiency: Insufficient innate endowment leads to weakness of the innate foundation, which is unable to generate acquired qi and blood.

[0006] Acquired malnutrition: The spleen and stomach are the foundation of acquired constitution, responsible for transforming and transporting the essence of food and water into qi and blood. If the spleen and stomach are damaged due to irregular diet, overeating, prolonged diarrhea or vomiting, or excessive fatigue, the production of qi and blood will be insufficient.

[0007] Qi deficiency leads to insufficient blood production: Qi deficiency causes abnormal transportation and transformation functions, which cannot ascend clear yang and descend turbid yin. As a result, blood cannot be lifted and regulated, leading to blood deficiency (such as sallow complexion and brittle nails).

[0008] Blood deficiency and insufficient Qi: Blood deficiency leads to malnourishment of the heart, decreased heart function, and insufficient heart Qi, manifested as shortness of breath, fatigue, and weakness.

[0009] Post-illness depletion: External wind-cold, trauma, surgery, and long-term chronic diseases deplete the body's vital energy, leading to deficiency of both qi and blood.

[0010] The symptoms of qi and blood deficiency mainly depend on whether it is qi deficiency or blood deficiency, or both. Qi deficiency manifests as shortness of breath, reluctance to speak, fatigue, spontaneous sweating, night sweats, chest tightness, pale and swollen tongue with a thin white coating, and a weak or deep pulse. Blood deficiency manifests as sallow complexion, brittle nails, dizziness, blurred vision, insomnia, dreaminess, pale and thin tongue with little coating, and a weak pulse. Both qi and blood deficiency can present with the above symptoms, such as sallow complexion accompanied by fatigue, palpitations, and shortness of breath.

[0011] Western medicine primarily treats anemia by supplementing with iron, such as ferrous sulfate and ferrous fumarate. However, traditional iron supplements have significant drawbacks: First, iron ions readily combine with phosphates and oxalates in food during intestinal absorption, forming insoluble complexes and resulting in low absorption rates. Second, iron supplements can irritate the gastrointestinal mucosa, and long-term use may cause adverse reactions such as nausea, vomiting, and constipation. Furthermore, simply supplementing with iron cannot address the problem of poor blood circulation, and its effectiveness is limited for sub-health conditions characterized by both blood and qi deficiency.

[0012] The basic principles of Traditional Chinese Medicine (TCM) in treating Qi and Blood deficiency are to replenish Qi and nourish Blood, and to strengthen the spleen and stomach. For Qi and Blood deficiency syndrome, Qi should be replenished first, followed by Blood nourishment; the commonly used treatment is Sijunzi Tang combined with Siwu Tang. For Blood deficiency and Qi stagnation syndrome, the focus is on nourishing Blood; the commonly used treatment is Danggui Yin and Ejiao. For Qi and Blood deficiency syndrome, both Qi and Blood need to be replenished and Blood nourished; the commonly used treatment is Bazhen Tang. For Blood deficiency and Wind-Dryness syndrome, Yin needs to be nourished and dryness moistened; the commonly used treatment is Danggui Yangxue Qingfei Tang. Commonly used clinical herbs include Astragalus, Codonopsis, Angelica, and Rehmannia. It is advisable to eat more foods that are easily absorbed by the spleen and stomach, such as red dates, longan, black sesame seeds, goji berries, yam, chicken, duck, and pork liver. Avoid overwork, maintain sufficient sleep, and engage in moderate exercise (such as Tai Chi or walking) to promote Qi and Blood circulation.

[0013] While these formulas can regulate qi and blood holistically, they have the following problems: the traditional decoction process for Chinese medicine is cumbersome, making it difficult for modern people to adhere to; some medicinal materials are potent, and long-term use may produce side effects; more importantly, traditional formulas often use large molecules with low bioavailability, making it difficult to meet modern people's needs for efficient absorption. Some use single Chinese herbs, such as donkey-hide gelatin or angelica. Although these products have a certain blood-tonifying effect, they suffer from problems such as single ingredients and incomplete mechanisms of action. For example, donkey-hide gelatin products mainly provide collagen and amino acids, lacking components that promote iron absorption; angelica products focus on invigorating blood circulation, with a relatively weak blood-tonifying effect. Single ingredients cannot achieve dual replenishment of qi and blood, and cannot comprehensively improve anemia and sub-healthy qi and blood conditions.

[0014] Yizhong Shengxue tablets are composed of Codonopsis pilosula, Dioscorea opposita, Coix lacryma-jobi (fried), Citrus reticulata peel, Pinellia ternata, Amomum villosum, Jujube, ferrous sulfate, and Glycyrrhiza uralensis. They have the functions of strengthening the spleen and stomach, replenishing qi and nourishing blood. They can remove dampness from the spleen and stomach and are used to treat symptoms such as sallow complexion, dizziness, poor appetite, palpitations, shortness of breath, abdominal distension after meals, fatigue, insomnia, and forgetfulness caused by spleen and stomach weakness and deficiency of both qi and blood.

[0015] The efficacy of the above-mentioned compositions is not yet certain. The physiological effects of drugs are closely related to their complex chemical components. Domestic and international research on their active ingredients mainly focuses on medicinal materials and indications, with little in-depth study of the relationship between active ingredients and activity. How to accurately simplify the formulation and identify its relevant effective components is of great significance for elucidating the mechanism of action. Furthermore, how to simplify the formulation to achieve the therapeutic effect of simultaneously treating both qi and blood deficiency and relieving fatigue is a difficult problem that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0016] In view of the shortcomings of the existing technology, the present invention provides a composition with the function of replenishing both qi and blood, its pharmaceutical preparation and application.

[0017] The objective of this invention is achieved through the following technical solution: A composition having the effect of simultaneously replenishing qi and blood, wherein the raw materials of the composition are composed of the following components in parts by weight: hesperidin 0.2-1 parts, norihesperidin 0.2-5 parts, codonopsis glycoside 0.05-0.2 parts, allantoin 0.1-1 parts, glycyrrhizin 0.1-1 parts, alder ketone 0.1-1 parts, rutin 0.02-0.2 parts, apigenin glycyrrhizin 0.2-2 parts, and glycyrrhizic acid ammonium 0.1-1 parts.

[0018] Preferably, the raw materials of the composition are composed of the following components in parts by weight: hesperidin 0.4-0.8 parts, norihesperidin 0.5-2 parts, codonopsis glycoside 0.08-0.1 parts, allantoin 0.2-0.5 parts, glycyrrhizin 0.1-0.5 parts, alder 0.1-0.5 parts, rutin 0.05-0.1 parts, apigenin glycyrrhizin 0.5-1 parts, and glycyrrhizic acid ammonium 0.5-1 parts.

[0019] Preferably, the mass ratio of glycyrrhizin to apigenin is 1:1-2.

[0020] Preferably, the mass ratio of codonopsis glycoside to rutin is 1:0.5-1.5.

[0021] Preferably, the raw materials of the composition are composed of the following components in parts by weight: 0.6 parts of hesperidin, 1 part of norihesperidin, 0.1 parts of codonopsis glycoside, 0.5 parts of allantoin, 0.4 parts of glycyrrhizin, 0.4 parts of alder, 0.07 parts of rutin, 0.7 parts of apigenin glycyrrhizin and 0.6 parts of ammonium glycyrrhizate.

[0022] A second objective of this invention is to provide a pharmaceutical preparation comprising the aforementioned composition having the effect of simultaneously replenishing qi and blood.

[0023] Preferably, the pharmaceutical preparation further includes pharmaceutically acceptable excipients.

[0024] For different dosage forms, appropriate drug carriers can be selected in this field.

[0025] The drug carrier used can be solid, liquid, or gaseous. Examples of solid carriers include lactose, kaolin, sucrose, talc, gelatin, agar, pectin, gum arabic, magnesium stearate, and stearic acid. Examples of liquid carriers include syrup, peanut oil, olive oil, and water. Examples of gaseous carriers include carbon dioxide and nitrogen.

[0026] In preparing compositions for oral dosage forms, any convenient pharmaceutical medium can be used. For example, water, ethanol, oils, alcohols, flavoring agents, preservatives, coloring agents, etc., can be used to form oral liquid dosage forms, such as suspensions and solutions; while carriers, such as starch, sugars, microcrystalline cellulose, diluents, granulators, emulsifiers, lubricants, binders, and disintegrants, can be used to form oral solid dosage forms, such as powders, capsules, and tablets. Tablets and capsules are preferred oral dosage units using solid pharmaceutical carriers due to their ease of administration. Tablets can be coated using standard aqueous or non-aqueous techniques.

[0027] Tablets containing the traditional Chinese medicine composition of the present invention can be prepared by compression or molding, and one or more excipients or adjuvants may be used. The active ingredient can be compressed in a free-flowing form (e.g., powder or granules) in a suitable machine, optionally mixed with binders, lubricants, inert diluents, surfactants, or dispersants. Molded tablets can be molded in a suitable machine, i.e., a powdery mixture moistened with an inert liquid diluent, each tablet preferably containing about 0.05 mg to about 5 g of active ingredient, and each sachet or capsule preferably containing about 0.05 mg to about 5 g of active ingredient. For example, a formulation intended for oral administration to humans may contain about 0.5 mg to about 5 g of active drug, mixed with a suitable and convenient carrier material, which may comprise about 5% to 95% of the total composition. Unit dosage forms typically contain about 1 mg to about 2 g of active ingredient, typically in doses of 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg, 500 mg, 600 mg, 800 mg, or 1000 mg.

[0028] The pharmaceutical compositions of this invention suitable for parenteral administration can be prepared as aqueous solutions or suspensions of the active compound and may include suitable surfactants, such as hydroxypropyl cellulose. Dispersions can also be prepared in mixtures of glycerol, liquid polyethylene glycol, and their oils. Furthermore, preservatives may be added to prevent harmful microbial growth.

[0029] The medicaments of the present invention can be in forms suitable for topical use, such as aerosols, creams, ointments, lotions, powders, or the like. Furthermore, the compositions can be in suitable forms for transdermal drug delivery devices. These formulations can be prepared using the traditional Chinese medicine compositions of the present invention through conventional processing methods. For example, a cream or ointment with a desired consistency can be prepared by mixing a hydrophilic material and water, and about 5 wt% to about 10 wt% of the compound.

[0030] The medicament of the present invention can be in a form suitable for rectal administration, wherein the carrier is solid. It is preferable to formulate the mixture into a single-dose suppository. Suitable carriers include cocoa butter and other materials commonly used in the art. Suppositories can be made by first forming a mixture containing a softened or melted carrier, followed by cooling and shaping in a mold.

[0031] In addition to the carrier components mentioned above, the pharmaceutical formulations may include (if applicable) one or more additional carrier components, such as diluents, buffers, flavoring agents, binders, surfactants, thickeners, lubricants, preservatives (including antioxidants), etc. Furthermore, other excipients may be added, such as lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, colorants, and flavoring agents, and the components containing the traditional Chinese medicine composition of this invention can also be prepared in powder or concentrated form.

[0032] Preferably, the pharmaceutically acceptable excipient is selected from one or more of fillers, disintegrants, flavoring agents, binders, surfactants, preservatives, lubricants, and gliding agents.

[0033] Preferably, the dosage form of the pharmaceutical preparation is selected from tablets, granules, capsules, oral liquids, or powders.

[0034] A third objective of this invention is to provide the application of the composition described above, which has the effect of simultaneously replenishing qi and blood, in the preparation of a medicine for preventing and treating qi deficiency and / or blood deficiency and / or anemia and / or fatigue.

[0035] Compared with the prior art, the beneficial effects of the present invention are as follows: (1) The present invention combines the components, and its synergistic effect is significantly better than that of the original Yizhong Shengxue tablets; the present invention combines the components, and the ingredients are clear and concise, and has significant effects of replenishing blood and qi, treating anemia and anti-fatigue.

[0036] (2) The complex structures of active substances in traditional Chinese medicine make it extremely difficult to elucidate their mechanisms of action and material basis, which is a major obstacle to the internationalization of traditional Chinese medicine and its global reach. This invention simplifies the prescription by breaking it down into smaller parts and combining specific active ingredients, resulting in better efficacy compared to the original prescription. Detailed Implementation

[0037] The technical solution of the present invention will be further described below with reference to specific embodiments. The raw materials used in the following embodiments are all commercially available conventional raw materials, and their specific sources are shown in Table 1 below, but are not limited to the listed manufacturers.

[0038] Table 1

[0039] Example 1 The Qi and Blood Nourishing Composition of this embodiment contains the following raw materials: 0.6 parts of hesperidin, 1 part of tangeretin, 0.1 parts of codonopsis glycoside, 0.5 parts of allantoin, 0.4 parts of glycyrrhizin, 0.4 parts of alder, 0.07 parts of rutin, 0.7 parts of celery glycyrrhizin and 0.6 parts of ammonium glycyrrhizate, all of which are parts by weight.

[0040] The preparation method is as follows: Hesperidin, norihesperidin, codonopsis glycoside, allantoin, glycyrrhizin, alder, rutin, apigenin, and ammonium glycyrrhizate are mixed evenly to obtain the product.

[0041] Example 2 The Qi and Blood Nourishing Composition of this embodiment contains the following raw materials: 0.2 parts of hesperidin, 0.2 parts of tangeretin, 0.05 parts of codonopsis glycoside, 0.1 parts of allantoin, 0.1 parts of glycyrrhizin, 0.1 parts of alder, 0.02 parts of rutin, 0.2 parts of apigenin glycyrrhizin and 0.2 parts of glycyrrhizic acid ammonium, all of which are parts by weight.

[0042] The preparation method is as follows: Hesperidin, norihesperidin, codonopsis glycoside, allantoin, glycyrrhizin, alder, rutin, apigenin, and ammonium glycyrrhizate are mixed evenly to obtain the product.

[0043] Example 3 The Qi and Blood Nourishing Composition of this embodiment consists of the following ingredients: 1 part hesperidin, 4 parts tangeretin, 0.2 parts codonopsis glycoside, 1 part allantoin, 1 part glycyrrhizin, 1 part alder, 0.2 parts rutin, 2 parts apigenin glycyrrhizin and 1 part glycyrrhizic acid ammonium, all in parts by weight.

[0044] The preparation method is as follows: Hesperidin, norihesperidin, codonopsis glycoside, allantoin, glycyrrhizin, alder, rutin, apigenin, and ammonium glycyrrhizate are mixed evenly to obtain the product.

[0045] Comparative Example 1 The difference between this comparative example and Example 1 is that 1 part of hesperidin is replaced with hesperidin, and 0.6 parts of synephrine is replaced with hesperidin. The raw materials of the specific composition are composed of the following components: 0.6 parts of synephrine, 1 part of hesperidin, 0.1 parts of codonopsis glycoside, 0.5 parts of allantoin, 0.4 parts of glycyrrhizin, 0.4 parts of alder, 0.07 parts of rutin, 0.7 parts of apigenin glycyrrhizin, and 0.6 parts of ammonium glycyrrhizate, all of which are parts by weight.

[0046] Comparative Example 2 The only difference between this comparative example and Example 1 is that the codonopsis glycoside is removed and replaced with 0.05 parts of syringin and 0.05 parts of glycyrrhizin. The raw materials of the specific composition are composed of the following components: 0.6 parts of hesperidin, 1 part of norihesperidin, 0.05 parts of syringin, 0.05 parts of glycyrrhizin, 0.5 parts of allantoin, 0.4 parts of glycyrrhizin, 0.4 parts of alder, 0.07 parts of rutin, 0.7 parts of apigenin-glycyrrhizin and 0.6 parts of ammonium glycyrrhizate, all of which are parts by weight.

[0047] Comparative Example 3 The only difference between this comparative example and Example 1 is that alderne is replaced with sorbitol, rutin is replaced with oleanolic acid, and glycyrrhizin is replaced with ammonium glycyrrhizate. The specific composition consists of the following components: 0.6 parts hesperidin, 1 part norihesperidin, 0.1 parts codonopsis glycoside, 0.5 parts allantoin, 0.4 parts sorbitol, 0.07 parts oleanolic acid, 0.7 parts apigenin glycyrrhizin, and 1 part ammonium glycyrrhizate, all in parts by weight.

[0048] Comparative Example 4 This comparative example is the commercially available product Yizhong Shengxue Tablets (Jilin Huakang Pharmaceutical Co., Ltd., National Drug Approval Number Z10970125, specification 0.3g / tablet, 6 tablets at a time, three times a day).

[0049] Experimental Example: Pharmacodynamic Study of the Qi and Blood Nourishing Effect of the Invention 1. Experimental Materials Ninety female SPF-grade SD rats, weighing 190-230g, were used.

[0050] 2. Experimental Methods 2.1 Construction and administration of a rat model of qi and blood deficiency Animal modeling: After 3 days of acclimatization, all rats were randomly divided into four groups: control group, model group, Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, and Comparative Example 4 group, with 10 rats in each group. Except for the control group, the other groups were fed a low-iron diet (Beijing Botai Hongda Biotechnology Co., Ltd., catalog number HD007), and all rats had free access to deionized water. Except for the control group, the other groups underwent tail vein pleophoresis twice a week, with 1 mL of blood drawn each time, and were simultaneously administered senna leaf solution (concentration 0.2 kg·L⁻¹) by gavage. -1 10 mL·kg each time -1 Once daily. After maintaining the above modeling method for 2 weeks, when the differences in red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) between the model group and the control group are statistically significant, the rat model of qi and blood deficiency is considered complete. Administer medication immediately afterward, maintaining a low-iron diet during administration.

[0051] Animal administration method: The dosage for rats was calculated based on the dose conversion factor per kilogram of body weight between animals and humans. For Examples 1-3 and Comparative Examples 1-3, rats were given 50 mg / kg of the prepared composition (based on the total amount of active monomers). Comparative Example 4 was given 0.5 g / kg (calculated based on an adult weight of 70 kg; the equivalent dosage for rats is 6.3 times that of an adult, rounded to one decimal place). The drug solution was prepared using pure water as the solvent and was freshly prepared before use. Administered once daily by gavage (1 mL). The control group and model group were administered an equal volume of pure water by gavage. The administration was repeated once daily for 30 consecutive days. Various indicators of the rats were observed.

[0052] After the last administration, rats in all groups were fitted with a fuse weighing 5% of their body weight in their tails and placed in a circular bucket at a water temperature of 25℃ and a water depth of 40cm to swim. If a rat could not float to the surface after its nose was submerged for 10 seconds, it was immediately removed, and the swimming time was recorded. After the exhaustive swimming experiment, the rats were allowed free access to food and rested for one day, followed by a 12-hour fast. Blood was collected from the orbital sinus of each rat, and the values ​​of red blood cells (RBC), hemoglobin (HGB), and hematocrit (HCT) in peripheral blood were measured using an automated blood analyzer.

[0053] 2. Experimental Results (1) The results of the rats' exhaustion swimming time are shown in Table 2.

[0054] Table 2

[0055] Note: p<0.01 vs. blank group; # p<0.05, ## p<0.01 vs. model group; △ p<0.05 vs. Example 1 group.

[0056] The results in Table 2 show that the swimming time in the model group (5.4±1.3 min) was significantly lower than that in the blank group (9.5±0.7, p<0.01), confirming the successful establishment of the fatigue rat model.

[0057] Example 1 (10.6±1.1 min), Example 2 (9.9±0.8 min), and Example 3 (9.1±1.5 min) were all significantly better than the model group ( ## (p<0.01) indicates that the Qi and Blood Nourishing Compound Preparation of the present invention has a clear anti-fatigue effect, with Example 1 showing the best effect.

[0058] The average swimming times of Comparative Examples 1 to 4 were 8.7 min, 7.4 min, 7.0 min, and 6.3 min, respectively, all of which were better than those of the model group. #p<0.05), but significantly lower than in Example 1 ( △ (p<0.05) indicates that changes in the compatibility of the ingredients in the formula can lead to a decrease in efficacy. Specifically, in Comparative Example 1, where noriheptacortin and citrinin were removed and replaced with hesperidin and synephrine, the activity was weakened, indicating that noriheptacortin has a stronger synergistic effect with the other ingredients of this invention when the dosage remains unchanged. In Comparative Example 3, the activity decreased significantly after the replacement of the three components, indicating that alderne, rutin, and glycyrrhizin have a synergistic effect in anti-inflammatory, antioxidant, and vasodilatory properties. In summary, the active ingredients in the embodiments of this invention constitute a highly efficient synergistic system, which improves the anti-fatigue effect in rats with qi and blood deficiency.

[0059] (2) Improvement of anemia, the results are shown in Table 3.

[0060] Table 3

[0061] Note: p<0.01 vs. blank group; # p<0.05, ## p<0.01 vs. model group; △ p<0.05 vs. Example 1 group.

[0062] Table 3 shows that the red blood cell (RBC), hemoglobin (HGB), and hematocrit (HCT) levels in the model group rats were significantly lower than those in the blank group (p<0.01), confirming the successful establishment of the anemia model. The three indicators in Example 1, Example 2, and Example 3 groups were significantly higher than those in the model group (…). ## p<0.01 indicates that the compound preparation has a clear blood-tonifying effect, with Example 1 showing the best index value. Although the three indicators of Comparative Examples 1 to 4 were all better than the model group ( # p<0.05), but significantly lower than in Example 1 ( △ (p<0.05) indicates that changes in the type, quantity, and content of each component in the formula can lead to a decrease in efficacy. The precise formulation of each active ingredient in the embodiments of this invention can effectively improve anemia symptoms in rats with qi and blood deficiency, and has good application prospects.

[0063] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A composition having the effect of simultaneously replenishing qi and blood, characterized in that, The raw materials of the composition consist of the following components in parts by weight: hesperidin 0.2-1 parts, norihesperidin 0.2-5 parts, codonopsis glycoside 0.05-0.2 parts, allantoin 0.1-1 parts, glycyrrhizin 0.1-1 parts, alder 0.1-1 parts, rutin 0.02-0.2 parts, apigenin glycyrrhizin 0.2-2 parts, and ammonium glycyrrhizate 0.1-1 parts.

2. The composition with the dual function of replenishing qi and blood according to claim 1, characterized in that, The raw materials of the composition are composed of the following components in parts by weight: hesperidin 0.4-0.8 parts, norihesperidin 0.5-2 parts, codonopsis glycoside 0.08-0.1 parts, allantoin 0.2-0.5 parts, glycyrrhizin 0.1-0.5 parts, alder 0.1-0.5 parts, rutin 0.05-0.1 parts, apigenin glycyrrhizin 0.5-1 parts, and glycyrrhizic acid ammonium 0.5-1 parts.

3. The composition with the dual function of replenishing qi and blood according to claim 1, characterized in that, The mass ratio of glycyrrhizin to apigenin is 1:1-2.

4. The composition with the dual function of replenishing qi and blood according to claim 1, characterized in that, The mass ratio of codonopsis glycoside to rutin is 1:0.5-1.

5.

5. The composition with the dual function of replenishing qi and blood according to claim 1, characterized in that, The raw materials of the composition are composed of the following components in parts by weight: 0.6 parts of hesperidin, 1 part of norihesperidin, 0.1 parts of codonopsis glycoside, 0.5 parts of allantoin, 0.4 parts of glycyrrhizin, 0.4 parts of alder, 0.07 parts of rutin, 0.7 parts of apigenin glycyrrhizin and 0.6 parts of ammonium glycyrrhizate.

6. A pharmaceutical preparation, characterized in that, The composition comprising any one of claims 1-5 having the effect of replenishing both qi and blood.

7. The pharmaceutical preparation according to claim 6, characterized in that, The pharmaceutical preparation also includes pharmaceutically acceptable excipients.

8. The pharmaceutical preparation according to claim 7, characterized in that, The pharmaceutically acceptable excipients are selected from one or more of the following: fillers, disintegrants, flavoring agents, binders, surfactants, preservatives, lubricants, and gliding agents.

9. The pharmaceutical preparation according to claim 6, characterized in that, The dosage form of the pharmaceutical preparation is selected from tablets, granules, capsules, oral liquids, or powders.

10. The use of the composition according to any one of claims 1-5, which has the effect of replenishing both qi and blood, in the preparation of a medicament for preventing and treating anemia and / or fatigue.

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