一种促骨愈合的可吸收性骨蜡及其制备方法

By synergistically combining biodegradable copolymers and highly active functional components, the problems of low healing efficiency and mismatched degradation rates of bone wax are solved, achieving integrated hemostasis, degradation and bone induction, thus meeting the multifunctional needs of orthopedic surgery.

CN121971684BActive Publication Date: 2026-07-17HUBEI SHUANGXING PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUBEI SHUANGXING PHARMA CO LTD
Filing Date
2026-04-07
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing bone waxes suffer from low healing efficiency, insufficient synergy between the substrate and active ingredients, mismatched degradation rates, and limited functionality, making it difficult to meet the multifunctional needs of precision orthopedic surgery.

Method used

By employing a combination of biodegradable copolymers, magnesium-calcium silicate-biopeptide composite microspheres, mesoporous silica-loaded Panax notoginseng saponins and PTMC, and hydrogenated castor oil, the synergistic effect of the biodegradable substrate and highly active functional components is controlled to achieve integrated functions of hemostasis, degradation, and efficient bone induction.

Benefits of technology

It achieves a precise match between hemostasis, degradation and bone regeneration, enhances bone repair, and has excellent biocompatibility and manipulability, meeting the multifunctional needs of bone wax.

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Abstract

本发明涉及一种促骨愈合的可吸收性骨蜡及其制备方法,属于骨愈合材料技术领域,骨蜡包括可降解共聚物、PTMC、镁‑硅酸钙‑生物肽复合微球、介孔二氧化硅负载三七总皂苷和氢化蓖麻油。可降解共聚物为PEG、辛酸亚锡、D,L‑丙交酯、ε‑己内酯反应,沉淀制得。镁‑硅酸钙‑生物肽复合微球为多孔镁‑硅酸钙微球负载生物肽,再经聚多巴胺包覆制得。生物肽为单环刺螠经木瓜蛋白酶、胰蛋白酶逐级酶解获得的1kDa~5kDa之间肽段。各成分按特定比例复配制备骨蜡,突破传统骨蜡降解性差、功能单一的局限,实现止血、降解、高效骨诱导一体化功能。通过可控降解基材与高活性功能组分的协同,达成降解速率与骨再生周期精准匹配。
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