一种抗菌肽、制备方法与其在防治口腔问题中的应用
By modifying the red sea bream antimicrobial peptide Chrysophsin3, Chrysophsin3-2 was designed, optimizing its net positive charge, hydrophobic moment, and α-helicity. This solved the problem of high hemolytic toxicity of existing antimicrobial peptides, achieving stronger inhibition and killing ability of oral pathogens and higher safety, making it suitable for the treatment of oral diseases.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANDONG UNIV
- Filing Date
- 2026-04-03
- Publication Date
- 2026-07-17
AI Technical Summary
The existing antimicrobial peptide Chrysophsin3 exhibits hemolytic toxicity at low concentrations, limiting its application in the treatment of oral diseases. The key challenge is to improve its antimicrobial activity while reducing hemolytic toxicity.
By modifying the amino acid sequence of the red sea bream antimicrobial peptide Chrysophsin3, a novel antimicrobial peptide Chrysophsin3-2 was designed. The net positive charge, hydrophobic moment, and α-helicity were optimized to enhance the inhibitory and killing ability against oral pathogens, while reducing the hemolytic toxicity to mammalian erythrocytes.
Chrysophsin3-2 significantly enhances the inhibitory and bactericidal abilities against oral pathogens, especially Porphyromonas gingivalis and Streptococcus mutans, with a several-fold increase in both antibacterial and bactericidal activity. It also significantly reduces hemolytic toxicity, demonstrating superior cell selectivity and safety, and providing a higher-quality candidate molecule for the treatment of oral diseases.
Smart Images
Figure CN121974983B_ABST