A DNA sequencing system based on in-plane heterojunction and surface-enhanced raman scattering
CN121975925BActive Publication Date: 2026-07-21HANGZHOU FIRST PEOPLES HOSPITAL
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HANGZHOU FIRST PEOPLES HOSPITAL
- Filing Date
- 2026-04-02
- Publication Date
- 2026-07-21
AI Technical Summary
Technical Problem
In existing Raman scattering-based DNA sequencing schemes, nanopores have low molecular collection efficiency and can only perform single-sample detection.
Method used
A DNA sequencing system employing in-plane heterojunctions and surface-enhanced Raman scattering utilizes the affinity difference between the central band and DNA sequencing molecules. A current loop mechanism drives DNA molecules to move along the central band, and multiple detections are performed in a region with enhanced plasmon electric field generated at the metal nanoparticles.
Benefits of technology
This technology enables efficient capture of DNA molecules and repeated detection, improving the efficiency and accuracy of sequencing.
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Smart Images
Figure CN121975925B_ABST
Abstract
The present application relates to the field of biological detection, biotechnology and nanotechnology, and particularly relates to a DNA sequencing system based on in-plane heterojunction and surface enhanced Raman scattering, comprising: an in-plane heterojunction with a middle strip, an excitation light source, a current loop mechanism and a spectrometer; the in-plane heterojunction is provided with metal nanoparticles on both sides; the excitation light source is used for exciting the plasmon resonance of the metal nanoparticles; the current loop mechanism is used for driving the DNA sequencing molecules adsorbed on the heterojunction strip to move along the middle strip; and the spectrometer is used for detecting the Raman spectrum of the DNA sequencing molecules. The present application can efficiently capture and deterministically transport the sequencing molecules to the metal surface plasmon field enhancement region to complete the sequencing based on the Raman signal, and only needs to change the electric field direction in the current loop, so as to realize the back-and-forth movement of the molecules repeatedly through the electric field enhancement region to realize the repeated detection of the same molecule.
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