An anti-allergic composition containing a high mountained edelweiss and gentiana straminea

Abstract

The present application relates to a kind of containing high mountain fire and gentian's antiallergic composition, belong to cosmetic technical field.The antiallergic composition containing high mountain fire and gentian disclosed in the present application includes the following mass parts of components: gentian extract: 1-3 parts, high mountain firebrush extract: 1-3 parts, sapelli bark extract: 0.1-1 part, annona extract: 2-4 parts, the composition consisting of the mass parts of components described above has significant antiallergic efficacy.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and more particularly to an anti-allergic composition containing Edelweiss and Gentiana macrophylla. Background Technology

[0002] Currently, active ingredients used in cosmetics for allergy relief mainly fall into two categories: one is chemically synthesized drugs, such as antihistamines and corticosteroids. While these are highly effective, long-term use may lead to side effects such as skin dependence and thinning of the stratum corneum, raising safety concerns and making them unsuitable for everyday cosmetics; the other is natural plant extracts, such as licorice, chamomile, and purslane, which are favored for their gentleness. However, many existing natural allergy-relieving ingredients suffer from limitations such as single efficacy, slow onset of action, and insufficient effectiveness, failing to meet the urgent needs of people with sensitive skin for highly effective and rapid anti-allergy relief.

[0003] Furthermore, the interactions between different components are complex when using multiple plant extracts in combination. Improper formulation can not only fail to produce synergistic effects but may even inhibit each other, resulting in lower-than-expected anti-allergic effects or introducing unnecessary irritation risks. Therefore, developing a safe and gentle anti-allergic composition that is scientifically formulated from specific natural plant extracts, exhibiting significant synergistic effects, has become an important research direction in this field.

[0004] In conclusion, there is an urgent need to provide a cosmetic anti-allergy composition that is highly effective in reducing allergies, safe and gentle, and has a clear synergistic effect between its components for consumers to choose from. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art and provide an anti-allergic composition containing Edelweiss and Gentiana macrophylla.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0007] In a first aspect, the present invention provides an anti-allergic composition containing Edelweiss and Gentiana macrophylla, comprising the following components in parts by weight range: Gentiana macrophylla extract: 1-3 parts, Edelweiss extract: 1-3 parts, Dalbergia odorifera bark extract: 0.1-1 parts, and Prunus armeniaca extract: 2-4 parts.

[0008] The anti-allergy composition containing Edelweiss and Gentiana macrophylla obtained by selecting specific components in this invention has significant anti-allergy effects.

[0009] As a preferred embodiment of the anti-allergy composition containing Edelweiss and Gentiana macrophylla of the present invention, the anti-allergy composition containing Edelweiss and Gentiana macrophylla comprises the following components in parts by weight: Gentiana macrophylla extract: 2 parts, Edelweiss extract: 2 parts, Dalbergia odorifera bark extract: 0.5 parts, and Prunus armeniaca extract: 3 parts.

[0010] Under preferred weight ratios, the anti-allergy composition containing Edelweiss and Gentiana macrophylla of the present invention has a more significant anti-allergy effect.

[0011] In a second aspect, the present invention provides the application of the anti-allergic composition containing Edelweiss and Gentiana macrophylla described in the first aspect in the preparation of cosmetics with anti-allergic effects.

[0012] As a preferred embodiment of the application described in this invention, the cosmetic dosage form includes any one of lotion, cream, serum, mask, and spray.

[0013] Thirdly, the present invention provides an anti-allergic serum, the serum comprising the anti-allergic composition containing Edelweiss and Gentiana macrophylla as described in the first aspect; the serum contains 0.5%-5wt% of the anti-allergic composition.

[0014] As a preferred embodiment of the anti-allergic serum described in this invention, the serum further includes skin conditioning agents, thickeners, preservatives, and deionized water.

[0015] As a preferred embodiment of the anti-allergic serum described in this invention, the skin conditioning agent includes at least one of panthenol, erythritol, betaine, squalane, sodium hyaluronate, centella asiatica extract, trehalose, and tetrahydromethylpyrimidine carboxylic acid.

[0016] As a preferred embodiment of the anti-allergic serum of the present invention, the thickener includes at least one of xanthan gum, dehydroxanthan gum, carbomer, sclerotium gum, polyacrylate crosspolymer-6, ammonium acryloyldimethyl taurate / VP copolymer, and sodium polyacryloyldimethyl taurate.

[0017] As a preferred embodiment of the serum with anti-allergic effects described in this invention, the preservative includes at least one of phenoxyethanol, p-hydroxyacetophenone, capryloyl hydroxamic acid, and 1,2-pentanediol.

[0018] Fourthly, the present invention provides a method for preparing the anti-allergic serum described in the third aspect, the method comprising the following steps:

[0019] A1: Mix the anti-allergy composition with 1 / 4 deionized water until homogeneous to obtain mixture A;

[0020] A2: Mix the skin conditioning agent, preservative and 1 / 4 deionized water evenly to obtain mixture B;

[0021] A3: Heat the thickener and 1 / 4 deionized water to 70-80℃ and stir until homogeneous to obtain mixture C;

[0022] A4: Cool mixture C to 40-45℃, then add mixture A, mixture B, and the remaining deionized water and stir well to obtain an essence with anti-allergic effects.

[0023] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0024] 1. Synergistic effect of multiple targets, comprehensive anti-allergy mechanism

[0025] The core advantage of this invention is that the four plant extracts in the composition are not simply mixed, but form a multi-target, multi-link synergistic network targeting the complex pathways of skin allergic reactions.

[0026] Gentiana macrophylla extract and Edelweiss extract are the core anti-allergy ingredients. They mainly act on the source and signaling pathway of the inflammatory response, and can synergistically inhibit the production and release of key pro-inflammatory factors, thereby reducing the inflammatory cascade response from the upstream.

[0027] The extract of Dalbergia odorifera bark focuses on the repair and stabilization of the skin barrier, which can enhance the skin's ability to resist external stimuli and may also play a regulatory role in the excessive response of immune cells, providing a solid barrier foundation for anti-inflammation.

[0028] Wood apple extract, rich in bioactive components, can effectively stabilize sensitive cells in the skin and inhibit the release of itch-inducing mediators such as histamine, thereby specifically relieving the itching sensation associated with allergies.

[0029] Through the aforementioned mechanism, the four components each play a unique role in four key areas: "inhibiting inflammatory signals," "repairing the skin barrier," "stabilizing sensitive cells," and "relieving itching." They mutually reinforce each other, forming a complete anti-allergy chain and achieving synergistic effects. This allows the composition to address complex skin sensitivity issues more comprehensively and effectively, with effects far exceeding those of single ingredients or ordinary formulations.

[0030] 2. Optimize the proportions to maximize synergistic effects.

[0031] Through inventive exploration, this invention has determined the specific mass range of each component that produces the optimal synergistic effect. At this ratio, the efficacy of each component is balanced, effectively covering different pathways of skin allergies while avoiding effect bottlenecks or mutual inhibition caused by an excess or deficiency of any single component. This ensures the entire synergistic network operates at its optimal state, thereby maximizing the overall anti-allergic efficacy of the composition.

[0032] 3. Derived from natural ingredients, highly safe.

[0033] All active ingredients in this composition are derived from natural plant extracts, making them gentle and with a mechanism of action closer to the skin's physiological processes. They achieve anti-allergy effects through regulation and repair, rather than forcibly suppressing the skin, avoiding the potential irritation and side effects that chemically synthesized anti-allergy ingredients may cause. Therefore, they are safer and especially suitable for long-term care of sensitive skin.

[0034] In summary, this invention, through the scientific combination of Gentiana macrophylla extract, Edelweiss extract, Dalbergia odorifera bark extract, and Prunus armeniaca extract, utilizes their multi-target synergistic mechanism in the anti-allergy pathway to not only provide a highly effective anti-allergy solution, but also, due to its comprehensive, gentle, and safe properties, it has outstanding substantial characteristics and significant progress in the field of anti-allergy cosmetics. Detailed Implementation

[0035] To make the objectives, technical solutions, and advantages of the compositions or serums of the present invention clearer, the technical solutions in the compositions or serums of the present invention will be clearly and completely described below. Unless otherwise specified, the conditions in the compositions or serums shall be performed under conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, the components in the formulations of the compositions or serums are all conventional commercially available products. The following compositions or serums are further illustrations of the present invention, but not limitations thereof.

[0036] The sources of some of the raw materials in the anti-allergic composition containing Edelweiss and Gentiana macrophylla of the present invention are as follows:

[0037] Gentiana macrophylla extract, manufactured by Zhejiang Zhongke Zhongzhi Biotechnology Co., Ltd., product number Tangola™-Gentiana macrophylla anti-allergy stock solution;

[0038] Alpine edelweiss extract, manufactured by DSM, product number ALPAFLOR®EDELWEISS CB;

[0039] Pterocarya bark extract, manufactured by Guangzhou Fuen Biotechnology, product number FE286 Pterocarya strychnifolia;

[0040] Wood apple extract, manufactured by Guangzhou Luojie, product number Tannaka extract CI.

[0041] Unless otherwise specified, all other materials and reagents used in the composition or serum are commercially available.

[0042] Preparation of an anti-allergic composition containing Edelweiss and Gentiana macrophylla

[0043] Composition 1

[0044] Composed of the following components by mass:

[0045] Gentiana macrophylla extract: 2 parts;

[0046] Edelweiss extract: 2 parts;

[0047] Dalbergia odorifera bark extract: 0.5 parts;

[0048] Wood apple extract: 3 parts;

[0049] Preparation method: Mix the above components evenly, seal and store in the dark.

[0050] Composition 2

[0051] Composed of the following components by mass:

[0052] Gentiana macrophylla extract: 1 part;

[0053] Edelweiss extract: 1 part;

[0054] Dalbergia odorifera bark extract: 0.1 part;

[0055] Wood apple extract: 2 parts;

[0056] The preparation method is the same as that of composition 1.

[0057] Composition 3

[0058] Composed of the following components by mass:

[0059] Gentiana macrophylla extract: 3 parts;

[0060] Edelweiss extract: 3 parts;

[0061] Dalbergia odorifera bark extract: 1 part;

[0062] Wood apple extract: 4 parts;

[0063] The preparation method is the same as that of composition 1.

[0064] Composition ①: Unlike composition 1, it lacks Gentiana macrophylla extract. The missing mass fraction is made up by Edelweiss extract, Dalbergia odorifera bark extract, and Prunus armeniaca extract in a mass ratio of 2:0.5:3. The remaining components, mass fractions, and preparation method of the composition are the same as those of composition 1.

[0065] Composition ②: Unlike composition 1, it lacks Edelweiss extract. The missing mass fraction is made up by Gentiana macrophylla extract, Dalbergia odorifera bark extract, and Prunus armeniaca extract in a mass ratio of 2:0.5:3. The remaining components, mass fractions, and preparation methods of the composition are the same as those of composition 1.

[0066] Composition ③: Unlike composition 1, it lacks the extract of Dalbergia odorifera bark. The missing mass parts are made up by the extracts of Gentiana macrophylla, Edelweiss, and Apple of the Wood in a mass ratio of 2:2:3. The remaining components, mass parts, and preparation methods of the composition are the same as those of composition 1.

[0067] Composition ④: Unlike composition 1, it lacks wood apple extract. The missing mass fraction is made up by extracts of Gentiana macrophylla, Edelweiss, and Dalbergia odorifera bark in a mass ratio of 2:2:0.5. The remaining components, mass fractions, and preparation methods of the composition are the same as those of composition 1.

[0068] Composition ⑤

[0069] Composed of the following components by mass:

[0070] Gentiana macrophylla extract: 0.5 parts;

[0071] Edelweiss extract: 4 parts;

[0072] Dalbergia odorifera bark extract: 2 parts;

[0073] Wood apple extract: 1 part;

[0074] The preparation method is the same as that of composition 1.

[0075] Preparation of serums with anti-allergic effects

[0076] Serum 1

[0077] Composed of the following components by mass percentage:

[0078] Composition 1: 3wt%

[0079] Skin conditioning agent: 5 wt%;

[0080] Thickener: 0.5 wt%;

[0081] Preservative: 0.1 wt%;

[0082] Deionized water to 100 wt%;

[0083] The skin conditioning agent is composed of sodium hyaluronate, panthenol, and erythritol in a mass ratio of 1:0.4:0.2; the thickener is composed of carbomer and sclerotium gum in a mass ratio of 1:0.4; and the preservative is p-hydroxyacetophenone.

[0084] The preparation method includes the following steps:

[0085] A1: Mix the composition with 1 / 4 deionized water until homogeneous to obtain mixture A;

[0086] A2: Mix the skin conditioning agent, preservative and 1 / 4 deionized water evenly to obtain mixture B;

[0087] A3: Heat the thickener and 1 / 4 deionized water to 80°C and stir until homogeneous to obtain mixture C;

[0088] A4: Cool mixture C to 40°C, then add mixture A, mixture B, and the remaining deionized water and stir well to obtain an essence with anti-allergic effects.

[0089] Essence 2: Unlike Essence 1, it uses Composition 2 to replace Composition 1 by the same mass percentage, while the remaining components, mass percentages, and preparation methods are the same as those in Essence 1.

[0090] Essence 3: Unlike essence 1, composition 3 is used to replace composition 1 by the same mass percentage, while the remaining components, mass percentages, and preparation methods are the same as those of essence 1.

[0091] Essence 4: Unlike essence 1, composition 1 has a mass percentage of 0.5 wt%, while the remaining components, mass percentages, and preparation methods are the same as those of essence 1.

[0092] Essence 5: Unlike essence 1, composition 1 has a mass percentage of 5 wt%, while the remaining components, mass percentages, and preparation methods are the same as those of essence 1.

[0093] Essence ①: Unlike essence 1, composition ① is used to replace composition 1 by the same mass percentage, while the remaining components, mass percentages, and preparation methods are the same as those of essence 1.

[0094] Essence ②: Unlike essence 1, composition 2 is used to replace composition 1 by the same mass percentage, while the remaining components, mass percentages, and preparation methods are the same as those of essence 1.

[0095] Essence ③: Unlike essence 1, composition 3 is used to replace composition 1 by the same mass percentage, while the remaining components, mass percentages, and preparation methods are the same as those of essence 1.

[0096] Essence ④: Unlike essence 1, composition 1 is replaced by composition ④ by the same mass percentage, while the remaining components, mass percentages, and preparation methods are the same as those of essence 1.

[0097] Essence ⑤: Unlike essence 1, composition 1 is replaced by composition ⑤ in the same mass percentage. The remaining components, mass percentages, and preparation methods are the same as those of essence 1.

[0098] Blank Essence

[0099] Composed of the following components by mass percentage:

[0100] Skin conditioning agent: 5 wt%;

[0101] Thickener: 0.5 wt%;

[0102] Preservative: 0.1 wt%;

[0103] Deionized water to 100 wt%;

[0104] The skin conditioning agent is composed of sodium hyaluronate, panthenol, and erythritol in a mass ratio of 1:0.4:0.2; the thickener is composed of carbomer and sclerotium gum in a mass ratio of 1:0.4; and the preservative is p-hydroxyacetophenone.

[0105] The preparation method includes the following steps:

[0106] A1: Mix the skin conditioning agent, preservative and 1 / 4 deionized water evenly to obtain mixture B;

[0107] A2: Heat the thickener and 1 / 4 deionized water to 80°C and stir until homogeneous to obtain mixture C;

[0108] A3: Cool mixture C to 40°C, then add mixture B and the remaining deionized water and stir well to obtain an essence with anti-allergic effects.

[0109] Verification of the anti-allergic efficacy of the composition:

[0110] Test A: Anti-allergic activity test

[0111] Skin allergies can cause symptoms such as allergic dermatitis and itching. By studying the inhibitory effect of the test sample on oxazolone-induced ear contact allergic dermatitis in mice and compound 48 / 80-induced itching in mice, the anti-allergic activity of the skin care composition of the present invention was evaluated.

[0112] Test samples: Prepare 3wt% test samples of the compositions (compositions 1-3, compositions ①-⑤) using deionized water. Prepare test samples as needed.

[0113] A-1: Inhibitory effect of the composition on oxazolone-induced contact allergic dermatitis in mice.

[0114] Oxazolone (OXA) is a hapten. Stimulating mouse skin with the hapten can induce symptoms and pathological features similar to atopic dermatitis.

[0115] Experimental Methods: Eight-week-old female BALB / c mice were randomly divided into a blank control group (group 1) and an experimental group (groups 8, representing the test samples of compositions 1-3 and 1-5, respectively), with 10 animals in each group. Oxazolidone was prepared as a 3wt% solution (solvent composed of olive oil and acetone in a mass ratio of 4:1). 50 μL of the 3wt% oxazolidone solution was used to treat the shaved abdomen of the BALB / c mice. Five days later, 20 μL of a 2wt% oxazolidone-acetone solution was used to stimulate allergic reactions on the back of the left ear, while the right ear remained untreated. One hour later, 20 μL of deionized water (blank group) and the test sample (experimental group) were applied to the back of the left ear, while the right ear remained untreated. Twenty-four hours later, the animals were euthanized by cervical dislocation, and 8 mm diameter holes were made in both ears. The ears were weighed separately, and the difference was calculated. The inhibition rate of the inflammatory response was calculated by comparing the differences in ear weight among the treatment groups. The test results are shown in Table 1.

[0116] Inflammation suppression rate (%) = (Difference in the control group - Difference in the experimental group) / Difference in the control group × 100%

[0117] A-2: Inhibitory effect of the composition on compound 48 / 80-induced pruritus in mice

[0118] Experimental Methods: Eight-week-old female BALB / c mice were randomly divided into a model group (group 1) and an experimental group (groups 8, representing the test samples of compositions 1-3 and compositions ①-⑤, respectively), with 10 animals in each group. The mice were shaved on their backs the day before the experiment, with the shaved area approximately 2×2 cm. 2 On the day of the experiment, compound 48 / 80 (0.1 wt%, with physiological saline solution) was evenly applied to the backs of BALB / c mice to induce an itching response. Subsequently, 2 mL of physiological saline was applied to the model group, and 2 mL of the test sample was applied to the experimental group. The behavior of the mice was immediately observed, and the number of times the mice scratched within 30 minutes was recorded. The inhibition rate of the itch response was calculated by comparing the difference in the number of scratches between the two groups. The test results are shown in Table 1.

[0119] Itching suppression rate (%) = (Number of scratches in the model group - Number of scratches in the experimental group) / Number of scratches in the model group × 100%

[0120] In Table 1, the average inhibition rate of inflammation / itching is calculated as the sum of the inhibition rates of inflammation / itching within the group / the number of mice in the group.

[0121] Table 1. Average inhibitory rate of the composition on inflammation / itching

[0122] Test sample Average inflammation suppression rate (%) Average pruritus suppression rate (%) Composition 1 58.4 60.7 Composition 2 55.7 51.8 Composition 3 57.2 57.1 Composition ① 35.1 26.8 Composition ② 33.6 28.6 Composition ③ 42.5 19.6 Composition ④ 31.4 33.9 Composition ⑤ 47.3 39.3

[0123] As shown in Table 1, the extracts of Gentiana macrophylla, Edelweiss, Dalbergia odorifera bark, and Prunus armeniaca in the composition provided by this invention have a significant synergistic effect within the mass fraction range specified in this invention, and exhibit significant anti-allergic efficacy when used together. Comparing the results of compositions 1-3 with composition ⑤, it can be seen that the anti-allergic effect of each component in the composition of this invention is the best within the mass fraction range specified in this invention. Comparing the results of composition 1 with compositions ①-④, it can be seen that the extracts of Gentiana macrophylla, Edelweiss, Dalbergia odorifera bark, and Prunus armeniaca in the composition provided by this invention have a significant synergistic effect, and exhibit significant anti-allergic efficacy when used together.

[0124] Human efficacy verification

[0125] Test B: Safety Evaluation

[0126] The irritation of cosmetics was evaluated using the 2015 Cosmetic Safety Technical Specifications as a reference standard. The test method was a skin patch test, and the test was conducted on subjects aged 16-65 years who were randomly distributed. Each subject was assigned to all test products, for a total of 33 subjects.

[0127] Test substances: serums 1-5, serums ①-⑤, and blank serum.

[0128] Test Method: Eleven test areas were marked on the subject's back. The test substance (0.020-0.025g) was placed in a patch applicator. The applicator containing the test substance was then covered with non-irritating adhesive tape over the test area. The patch was gently pressed onto the skin surface with the palm of the hand to ensure even adhesion. The application was left for 24 hours. Thirty minutes after removing the patch applicator, once the pressure marks had disappeared, the skin reaction was observed. If the result was negative, repeat observations were performed at 24 and 48 hours post-pattern testing.

[0129] Evaluation criteria:

[0130] Grade 0: Negative reaction;

[0131] Grade 1: Suspicious reaction, with only slight erythema;

[0132] Grade 2: Weak positive reaction, erythema, infiltration, edema, and possible papules;

[0133] Grade 3: Strong positive reaction, erythema, infiltration, edema, papules may be present, and the reaction may extend beyond the test area;

[0134] Grade 4: Extremely positive reaction, with obvious erythema, severe infiltration, edema, confluent herpes, and reaction extending beyond the test area.

[0135] Test results: All subjects had negative skin reactions, indicating that the essence provided by this invention is mild, non-irritating, and highly safe.

[0136] Experiment C: Anti-allergy efficacy test of serum

[0137] Test samples: serums 1-5, serums ①-⑤, blank serum.

[0138] Test area: face.

[0139] Experiment duration: 28 days.

[0140] Test method:

[0141] Subject selection: Subjects with a lactic acid stinging score ≥3 were selected through a lactic acid stinging test and divided into 11 groups of 30 people each.

[0142] On day 0 of the trial, subjects underwent a lactic acid stinging test, and their lactic acid stinging scores were collected and recorded as T0. They then received the test sample and used it twice a day after cleansing their face, morning and evening, with a single application of 2 mL. The application area was the face. The day after the trial ended, subjects returned to the test site to undergo another lactic acid stinging test, and their lactic acid stinging scores were collected and recorded as T1. The rate of decrease in lactic acid stinging scores was calculated according to a formula to evaluate the anti-allergic efficacy of the test sample.

[0143] The rate of decrease in lactic acid stinging score (%) = (T0-T1) / T0 × 100%

[0144] Mean decrease rate of lactic acid stinging score = Sum of decrease rates of lactic acid stinging score within the group / Number of subjects in the group

[0145] The lactic acid stinging test method and scoring criteria are as follows:

[0146] Filter paper (0.8±0.1cm in diameter) soaked in 50μL of 10wt% lactic acid solution was applied to both sides of the subject's nasolabial folds. When the subject's subjective sensation (stinging and / or itching) in both sides of the nasolabial folds was moderate or above, the filter paper was removed and the subject's stimulation sensation was recorded.

[0147] The rating scale uses a 4-point system: 0 points for no sensation, 1 point for mild sensation, 2 points for moderate sensation, and 3 points for severe sensation. Intermediate scores, such as 0.5 or other intermediate values, can be used to describe the degree of sensation.

[0148] The higher the average decrease rate of lactic acid stinging score, the better the anti-allergic effect of the sample. The test results are shown in Table 2.

[0149] Table 2. Effect of serum on the rate of decrease in lactic acid stinging score.

[0150] Test sample Average decrease rate (%) in lactic acid stinging score Serum 1 28.13 Serum 2 25.86 Serum 3 27.53 Serum 4 13.44 Serum 5 28.72 Serum ① 15.15 Serum ② 12.90 Serum ③ 14.71 Essence ④ 12.50 Essence ⑤ 14.83 Blank Essence 2.68

[0151] As shown in Table 2, the composition provided by this invention has good anti-allergic effects. Comparing the results of serums 1-5 with the blank serum, it can be seen that the efficacy of the serums in this invention is mainly related to the composition. Comparing the results of serum 1 with serums 4 and 5, it can be seen that the amount of the composition added has a significant impact on the efficacy of the serum. Comparing the results of serum 1 with serums ①-④, it can be seen that the extracts of Gentiana macrophylla, Edelweiss, Dalbergia odorifera bark, and Prunus armeniaca in the composition have a significant synergistic effect, and the anti-allergic effect is best when used together. Comparing the results of serums 1-3 with serum ⑤, it can be seen that the mass fraction of each raw material in the composition has a certain impact on the anti-allergic efficacy of the serum; the effect is best when the mass fraction of the raw materials used in the composition is within the mass fraction range described in this invention.

[0152] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0153] It should also be noted that the various specific technical features described in the above embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

[0154] Furthermore, various different embodiments of the present invention can be combined in any way, as long as they do not violate the spirit of the present invention, they should also be regarded as the content disclosed by the present invention.

Claims

1. An anti-allergic composition containing Edelweiss and Gentiana macrophylla, characterized in that, The anti-allergic composition comprises the following components in parts by weight: Gentiana macrophylla extract: 1-3 parts; Edelweiss extract: 1-3 parts; Dalbergia odorifera bark extract: 0.1-1 part; Wood apple extract: 2-4 parts.

2. The anti-allergic composition according to claim 1, characterized in that, The anti-allergic composition comprises the following components in parts by weight: Gentiana macrophylla extract: 2 parts; Edelweiss extract: 2 parts; Dalbergia odorifera bark extract: 0.5 parts; Wood apple extract: 3 parts.

3. The use of the anti-allergic composition as described in claim 1 or 2 in the preparation of cosmetics with anti-allergic effects.

4. The application as described in claim 3, characterized in that, The cosmetic dosage forms include any one of lotion, cream, serum, mask, and spray.

5. A serum with anti-allergic properties, characterized in that, The serum comprises the anti-allergic composition as described in claim 1 or 2; the serum contains 0.5wt%-5wt% of the anti-allergic composition.

6. The essence as described in claim 5, characterized in that, The serum also includes skin conditioning agents, thickeners, preservatives, and deionized water.

7. The essence as described in claim 6, characterized in that, The skin conditioning agent includes at least one of panthenol, erythritol, betaine, squalane, sodium hyaluronate, centella asiatica extract, trehalose, and tetrahydromethylpyrimidine carboxylic acid.

8. The essence as described in claim 6, characterized in that, The thickener includes at least one of xanthan gum, dehydroxanthan gum, carbomer, sclerotinia gum, polyacrylate crosspolymer-6, ammonium acryloyldimethyl taurate / VP copolymer, and sodium polyacryloyldimethyl taurate.

9. The essence as described in claim 6, characterized in that, The preservative includes at least one of phenoxyethanol, p-hydroxyacetophenone, octanoyl hydroxamic acid, and 1,2-pentanediol.

10. An essence as described in any one of claims 6-9, characterized in that, The preparation method of the serum includes the following steps: A1: Mix the anti-allergy composition with 1 / 4 deionized water until homogeneous to obtain mixture A; A2: Mix the skin conditioning agent, preservative and 1 / 4 deionized water evenly to obtain mixture B; A3: Heat the thickener and 1 / 4 deionized water to 70-80℃ and stir until homogeneous to obtain mixture C; A4: Cool mixture C to 40-45℃, then add mixture A, mixture B, and the remaining deionized water and stir well to obtain an essence with anti-allergic effects.