A photothermal-enzyme catalytic nanoparticle and a preparation method and application thereof
By using photothermal-enzymatic catalysis, nanoparticles responsively release enzymes in the tumor microenvironment, synergistically reshaping the tumor microenvironment, thus solving the dual barrier problem in the delivery of nanomedicines to tumors and achieving efficient and safe tumor treatment.
CN121987784BActive Publication Date: 2026-07-21SHENZHEN UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHENZHEN UNIV
- Filing Date
- 2026-04-09
- Publication Date
- 2026-07-21
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Figure CN121987784B_ABST
Abstract
The application relates to the field of nanobiomedicine, and discloses a photothermal-enzyme catalysis nanoparticle and a preparation method and application thereof. The photothermal-enzyme catalysis nanoparticle is constructed by cross-linking water-soluble self-doped polyaniline nanoparticles, human serum albumin, lactic acid oxidase and a thioacetal linker cleavable by active oxygen. The application integrates collagenase and lactic acid oxidase (LOx) into the same nanoparticle system through a thioacetal (TK) linker. Under the action of active oxygen (ROS) in a tumor microenvironment and H2O2 generated by LOx catalysis, the TK linker is cleaved, the activities of the two enzymes are synchronously activated, collagen matrix (a physical barrier) is degraded, lactic acid (a chemical barrier) is removed, the tumor microenvironment is efficiently reshaped, and the problems of limited single barrier regulation effect and difficult improvement of the tumor microenvironment are solved.
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Citation Information
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