一种促渗透皮纳米复合球肽及其制备方法和在制备头皮控油、防脱和抗衰产品中的应用

The preparation of nanocomposite spheroids using tocosolvan and poloxamer carriers solved the problems of solubility and stability of lipid-soluble peptides in water-based formulations, achieving efficient transdermal delivery and comprehensive cosmetic efficacy.

CN122005348BActive Publication Date: 2026-07-17ZHEJIANG HAOMAI TECH CO LTD

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG HAOMAI TECH CO LTD
Filing Date
2026-04-14
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In existing technologies, fat-soluble peptides exhibit poor solubility and low stability in water-based formulations, and their transdermal delivery is inadequate, making effective delivery difficult and hindering their commercial development and end-use efficacy in cosmetics.

Method used

Using tocoxelane and poloxamer as carriers, nanocomposite spheroids were prepared through a specific method to form a stable hydrophobic core and a hydrophilic protective layer, encapsulating lipid-soluble peptides and improving their permeability and stability in the skin.

Benefits of technology

It achieves highly efficient transdermal absorption of fat-soluble peptides, enhances the oil-controlling, hair loss-preventing, and anti-aging effects of cosmetics, promotes collagen production, and improves scalp health.

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Abstract

本申请涉及透皮递送和化妆品技术领域,特别涉及一种促渗透皮纳米复合球肽及其制备方法和在制备头皮控油、防脱和抗衰产品中的应用。该制备方法包括:将复合肽加入至第一有机溶剂中以第一温度(35℃‑45℃)加热溶解,得第一溶液;将托可索仑加入至第二有机溶剂中以第二温度(40℃‑60℃)加热溶解,得第二溶液;将泊洛沙姆加入至水中以第三温度(40℃‑60℃)加热溶解,得第三溶液;将第二溶液和第三溶液混合,得第四溶液;将第一溶液以第一速率(1mL / min‑3mL / min)加入至第四溶液中以第四温度(40℃‑50℃)分散。该促渗透皮纳米复合球肽稳定性高,透皮吸收性能优异,对头皮的控油、防脱和抗衰效果好。
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