A non-targeted single-molecule conductivity spectroscopy measurement device, apparatus and method

By combining active enrichment with dielectrophoresis tweezers and quantum tunneling effect, the problem of single-molecule conductivity spectrum detection in complex matrices has been solved, achieving efficient and sensitive single-molecule conductivity spectrum detection, which is suitable for rapid in-situ detection in complex matrices such as urine.

CN122016946BActive Publication Date: 2026-07-17ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Filing Date
2026-04-16
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies struggle to effectively capture and characterize extremely low abundance biomolecules using single-molecule conductivity spectra in complex matrices, and also suffer from electrode contamination and low detection sensitivity.

Method used

A non-targeted single-molecule conductivity spectroscopy measurement device is used. The strong capture and enrichment capability of dielectrophoresis tweezers is utilized to actively migrate target molecules to the nano gap through dielectrophoresis manipulation unit. The signal is detected by combining quantum tunneling effect, and anti-adsorption modification is performed on the electrode surface to suppress impurity adsorption.

Benefits of technology

It enables efficient and sensitive single-molecule conductivity spectroscopy detection in complex matrices, reduces electrode contamination, and improves detection limits and capture efficiency, making it suitable for rapid in-situ detection in complex matrices such as urine.

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Abstract

This invention provides a non-targeted single-molecule conductivity spectroscopy measurement device, apparatus, and method. Based on a tunneling device integrating dielectrophoresis tweezers, it enables the capture and enrichment of molecules at extremely low concentrations in complex matrices, such as urine, and the detection of tunneling electrical signals—essentially, in-situ capture and detection. No pre-definition of the detection target is required before detection. The strong capture and enrichment capabilities of the dielectrophoresis tweezers allow for the collection of information from multiple molecules in the urine matrix. Using this device, tunneling electrical signal spectra corresponding to different urine samples can be obtained. Subsequently, multi-dimensional feature extraction is performed on the signal spectra, and accurate classification of different samples is achieved through a machine learning model.
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